gene

LIMK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LIMK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

0Hypotheses

0Analyses

50Outgoing

18Incoming

Summary

LIMK1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, expressed in, interacts with. Associated with Alzheimer. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	LIMK1
Full Name	LIM Domain Kinase 1
Chromosome	7q11.23
Protein Type	Serine/Threonine Kinase
Function	LIMK1 is a key regulator of actin dynamics
Primary Expression	the brain, particularly in regions involved in learning and memory, and is implicated in synaptic plasticity, neuronal development, and various neurod
Molecular Weight	72 kDa
Pathways	Nf-Κb, Apoptosis, Toll-Like Receptor, Blood-Brain Barrier, unfolded protein response
UniProt ID	P53667
NCBI Gene ID	3984
Ensembl ID	ENSG00000106635
GeneCards	LIMK1
Human Protein Atlas	LIMK1
Associated Diseases	Alzheimer, Encephalitis, Multiple Sclerosis, Neuronal Structural Alterations
Interactions	COFILIN, PUMA, Cofilin, PSD95, TAU, SOX2
KG Connections	72 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LIMK1["<b>LIMK1</b>"]
    Cofilin["Cofilin"]
    LIMK1 -->|"interacts with"| Cofilin
    Alzheimer{"Alzheimer"}
    LIMK1 -->|"inhibits"| Alzheimer
    COFILIN["COFILIN"]
    LIMK1 -->|"inhibits"| COFILIN
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    LIMK1 -->|"inhibits"| ALZHEIMER_S_DISEASE
    PUMA["PUMA"]
    LIMK1 -->|"inhibits"| PUMA
    ALZHEIMER["ALZHEIMER"]
    LIMK1 -->|"inhibits"| ALZHEIMER
    Neuron["Neuron"]
    LIMK1 -->|"expressed in"| Neuron
    Fibroblast["Fibroblast"]
    LIMK1 -->|"expressed in"| Fibroblast
    Stem_Cell["Stem Cell"]
    LIMK1 -->|"expressed in"| Stem_Cell
    neurodegeneration["neurodegeneration"]
    LIMK1 -->|"implicated in"| neurodegeneration
    ALZHEIMER_S_DISEASE -->|"inhibits"| LIMK1
    ALZHEIMER -->|"inhibits"| LIMK1
    AND["AND"]
    AND -->|"inhibits"| LIMK1
    style LIMK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (54)

Target	Relation	Type	Str
Cofilin	interacts_with	protein	0.95
Neuronal Structural Alterations	associated_with	phenotype	0.90
Cofilin	regulates	protein	0.80
Encephalitis	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	inhibits	disease	0.65
COFILIN	inhibits	gene	0.60
PUMA	inhibits	gene	0.60
RAC1	associated_with	gene	0.60
ASC	associated_with	gene	0.60
GSDMD	associated_with	gene	0.60
TNF	associated_with	gene	0.60
PSD95	inhibits	gene	0.60
TAU	inhibits	gene	0.60
SOX2	inhibits	gene	0.60
MAP2	inhibits	gene	0.60
Rb	inhibits	protein	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AND	inhibits	gene	0.60
TCR	associated_with	gene	0.60
Nf-Κb	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Toll-Like Receptor	associated_with	pathway	0.60
Blood-Brain Barrier	associated_with	pathway	0.60
Epithelial	associated_with	cell_type	0.60
Monocyte	associated_with	cell_type	0.60
T Cell	associated_with	cell_type	0.60
Endothelial	associated_with	cell_type	0.60
Macrophage	associated_with	cell_type	0.60
Actin	associated_with	protein	0.60
Interleukin	associated_with	protein	0.60
Interferon	associated_with	protein	0.60
Neuron	inhibits	cell_type	0.60
Fibroblast	inhibits	cell_type	0.60
Stem Cell	inhibits	cell_type	0.60
Alzheimer's disease	inhibits	disease	0.60
stem cells	expressed_in	cell_type	0.60
neurons	expressed_in	cell_type	0.60
Alzheimer	associated_with	disease	0.60
ROCK1	activates	gene	0.55
Neuron	expressed_in	cell_type	0.55
Fibroblast	expressed_in	cell_type	0.55
Stem Cell	expressed_in	cell_type	0.55
RNA	activates	gene	0.55
unfolded protein response	participates_in	pathway	0.55
astrocytes	expressed_in	cell_type	0.55

Incoming (18)

Source	Relation	Type	Str
COFILIN	regulates	entity	0.60
COFILIN	inhibits	gene	0.60
PUMA	inhibits	gene	0.60
TAK1	associated_with	gene	0.60
TIRAP	associated_with	gene	0.60
PAK1	associated_with	gene	0.60
MYD88	associated_with	gene	0.60
NEK7	associated_with	gene	0.60
JNK	associated_with	gene	0.60
TRAF6	associated_with	gene	0.60
OCT4	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AND	inhibits	gene	0.60
CREB	associated_with	gene	0.60
ERK1/2	associated_with	gene	0.60
CD55	activates	gene	0.55
CFH	activates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LIMK1

Understanding Entity Pages

Summary

Wiki Pages (21)

LIMK1 Gene

williams-syndrome

ROCK1 Gene

PAK3 — p21-Activated Kinase 3

PAK2 Protein (p21-Activated Kinase 2)

Actin Cytoskeleton Dynamics in Neurodegeneration

ROCK2 Gene

VLDL Receptor

PAK1 Gene

p21-Activated Kinase 3 (PAK3) Protein

LATS1 — Large Tumor Suppressor Kinase 1, Hippo Pathway

LIM Kinase 2 (LIMK2)

G007-LK: LRRK2 Kinase Inhibitor

Cofilin-1 — Actin-Depolymerizing Factor

CFL1 Protein

CD55

CFL1 Gene

Cofilin-1 Protein

Prefrontal Cortex Pyramidal Neurons in Executive Function