Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ZAP70: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | ZAP70 |
| Full Name | Zeta Chain T-Cell Receptor Associated Protein Kinase 70 |
| Chromosome | 2q11.82 |
| Protein Type | Kinase |
| Function | is a tyrosine kinase essential for T-cell receptor (TCR) signaling and adaptive immunity. |
| Ensembl ID | ENSG00000120217 |
| GeneCards | ZAP70 |
| Human Protein Atlas | ZAP70 |
| Associated Diseases | neurodegeneration |
| Interactions | TP53, CD19, EEF2, CCL5, TNF, TLR7 |
| KG Connections | 39 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ZAP70["<b>ZAP70</b>"]
Ms{"Ms"}
ZAP70 -->|"regulates"| Ms
Autism{"Autism"}
ZAP70 -->|"regulates"| Autism
Cardiovascular{"Cardiovascular"}
ZAP70 -->|"biomarker for"| Cardiovascular
Atherosclerosis{"Atherosclerosis"}
ZAP70 -->|"biomarker for"| Atherosclerosis
Diabetes{"Diabetes"}
ZAP70 -->|"biomarker for"| Diabetes
Als{"Als"}
ZAP70 -->|"biomarker for"| Als
ZAP70 -->|"biomarker for"| Ms
TP53["TP53"]
ZAP70 -->|"interacts with"| TP53
MIRNAS["MIRNAS"]
ZAP70 -->|"regulates"| MIRNAS
CD19["CD19"]
ZAP70 -->|"interacts with"| CD19
EEF2["EEF2"]
ZAP70 -->|"interacts with"| EEF2
CCL5["CCL5"]
ZAP70 -->|"interacts with"| CCL5
CD4["CD4"]
CD4 -->|"interacts with"| ZAP70
MAPK3["MAPK3"]
MAPK3 -->|"interacts with"| ZAP70
CD4 -->|"biomarker for"| ZAP70
style ZAP70 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | regulates | disease | 0.65 |
| Autism | regulates | disease | 0.65 |
| Cardiovascular | biomarker_for | disease | 0.65 |
| Atherosclerosis | biomarker_for | disease | 0.65 |
| Diabetes | biomarker_for | disease | 0.65 |
| Als | biomarker_for | disease | 0.65 |
| Ms | biomarker_for | disease | 0.65 |
| TP53 | interacts_with | gene | 0.60 |
| CD19 | interacts_with | gene | 0.60 |
| EEF2 | interacts_with | gene | 0.60 |
| CCL5 | interacts_with | gene | 0.60 |
| TNF | interacts_with | gene | 0.60 |
| TLR7 | interacts_with | gene | 0.60 |
| CAT | interacts_with | gene | 0.60 |
| ACTB | interacts_with | gene | 0.60 |
| RAC2 | interacts_with | gene | 0.60 |
| CTSD | interacts_with | gene | 0.60 |
| CDK4 | interacts_with | gene | 0.60 |
| CDKN1A | interacts_with | gene | 0.60 |
| LCK | interacts_with | gene | 0.60 |
| MFN1 | biomarker_for | gene | 0.60 |
| JAK3 | biomarker_for | gene | 0.60 |
| MIRNAS | regulates | gene | 0.60 |
| Mapk | interacts_with | pathway | 0.60 |
| DIABETES MELLITUS | biomarker_for | gene | 0.60 |
| IMMUNE INFILTRATION | biomarker_for | gene | 0.60 |
| APOPTOSIS | biomarker_for | gene | 0.60 |
| Apoptosis | biomarker_for | pathway | 0.60 |
| Tgf-Β | biomarker_for | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| CRISPR-Cas | participates_in | pathway | 0.60 |
| T cells | expressed_in | cell_type | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||