Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LCK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | LCK |
| Full Name | LCK Proto-Oncogene, Src Family Tyrosine Kinase |
| Aliases | Lymphocyte-Specific Protein Tyrosine Kinase |
| Chromosome | 1p35.2 |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | T-lymphocytes and is essential for T-cell receptor (TCR) signaling, playing a critical role in adaptive immunity PMID: 15035502 |
| Subcellular Localization | the cytoplasmic face of the plasma membrane. It is one of the earliest signaling molecules activated following TCR engag |
| Molecular Weight | 56 kDa |
| Exons | 12 |
| Pathways | NF-κB |
| NCBI Gene ID | 15035502 |
| Ensembl ID | ENSG00000182866 |
| GeneCards | LCK |
| Human Protein Atlas | LCK |
| Associated Diseases | Aging, Als, Alzheimer |
| Interactions | FYN, SRC, TCR, CD4, MAPK3, ZAP70 |
| KG Connections | 67 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
LCK["<b>LCK</b>"]
Ms{"Ms"}
LCK -->|"activates"| Ms
Leukemia{"Leukemia"}
LCK -->|"therapeutic target"| Leukemia
Als{"Als"}
LCK -->|"therapeutic target"| Als
LCK -->|"therapeutic target"| Ms
LCK -->|"regulates"| Ms
Autism{"Autism"}
LCK -->|"regulates"| Autism
Parkinson{"Parkinson"}
LCK -->|"activates"| Parkinson
LCK -->|"expressed in"| Ms
FYN["FYN"]
LCK -->|"activates"| FYN
SRC["SRC"]
LCK -->|"activates"| SRC
Mapk(["Mapk"])
LCK -->|"interacts with"| Mapk
Apoptosis(["Apoptosis"])
LCK -->|"activates"| Apoptosis
SRC -->|"activates"| LCK
FYN -->|"activates"| LCK
BCL2["BCL2"]
BCL2 -->|"therapeutic target"| LCK
CD4["CD4"]
CD4 -->|"interacts with"| LCK
MAPK3["MAPK3"]
MAPK3 -->|"interacts with"| LCK
ZAP70["ZAP70"]
ZAP70 -->|"interacts with"| LCK
TP53["TP53"]
TP53 -->|"interacts with"| LCK
MIRNAS["MIRNAS"]
MIRNAS -->|"regulates"| LCK
CD19["CD19"]
CD19 -->|"interacts with"| LCK
EEF2["EEF2"]
EEF2 -->|"interacts with"| LCK
CCL5["CCL5"]
CCL5 -->|"interacts with"| LCK
TNF["TNF"]
TNF -->|"interacts with"| LCK
style LCK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | activates | disease | 0.65 |
| Leukemia | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Autism | regulates | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| FYN | activates | gene | 0.60 |
| SRC | activates | gene | 0.60 |
| Mapk | interacts_with | pathway | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| TCR | activates | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| T cells | expressed_in | cell_type | 0.60 |
| TCR | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| P62 | associated_with | gene | 0.70 |
| SRC | activates | gene | 0.60 |
| FYN | activates | gene | 0.60 |
| BCL2 | therapeutic_target | gene | 0.60 |
| CD4 | interacts_with | gene | 0.60 |
| MAPK3 | interacts_with | gene | 0.60 |
| ZAP70 | interacts_with | gene | 0.60 |
| TP53 | interacts_with | gene | 0.60 |
| CD19 | interacts_with | gene | 0.60 |
| EEF2 | interacts_with | gene | 0.60 |
| CCL5 | interacts_with | gene | 0.60 |
| TNF | interacts_with | gene | 0.60 |
| TLR7 | interacts_with | gene | 0.60 |
| CAT | interacts_with | gene | 0.60 |
| ACTB | interacts_with | gene | 0.60 |
| RAC2 | interacts_with | gene | 0.60 |
| CTSD | interacts_with | gene | 0.60 |
| CDK4 | interacts_with | gene | 0.60 |
| CDKN1A | interacts_with | gene | 0.60 |
| MFN1 | associated_with | gene | 0.60 |
| PARKIN | associated_with | gene | 0.60 |
| UBIQUITIN | associated_with | gene | 0.60 |
| MFN2 | associated_with | gene | 0.60 |
| PTEN | activates | gene | 0.60 |
| PINK1 | associated_with | gene | 0.60 |
| CDK1 | inhibits | gene | 0.60 |
| CD19 | inhibits | gene | 0.60 |
| STAT1 | inhibits | gene | 0.60 |
| JUN | inhibits | gene | 0.60 |
| TAU | associated_with | gene | 0.60 |
| FYN | interacts_with | entity | 0.60 |
| MIRNAS | regulates | gene | 0.60 |
| LC3B | associated_with | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| TCR | activates | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| TAU PATHOLOGY | associated_with | gene | 0.60 |
| AMYLOID-BETA | associated_with | gene | 0.60 |
| ALPHA-SYNUCLEIN | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||