gene

LCK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LCK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

67Connections
0Hypotheses
0Analyses
22Outgoing
45Incoming

Summary

Page for LCK — LCK Proto-Oncogene, Src Family Tyrosine Kinase

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🧬 Gene Info
Gene SymbolLCK
Full NameLCK Proto-Oncogene, Src Family Tyrosine Kinase
AliasesLymphocyte-Specific Protein Tyrosine Kinase
Chromosome1p35.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionT-lymphocytes and is essential for T-cell receptor (TCR) signaling, playing a critical role in adaptive immunity PMID: 15035502
Subcellular Localizationthe cytoplasmic face of the plasma membrane. It is one of the earliest signaling molecules activated following TCR engag
Molecular Weight56 kDa
Exons12
PathwaysNF-κB
NCBI Gene ID15035502
Ensembl IDENSG00000182866
GeneCardsLCK
Human Protein AtlasLCK
Associated DiseasesAging, Als, Alzheimer
InteractionsFYN, SRC, TCR, CD4, MAPK3, ZAP70
KG Connections67 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

LCK — LCK Proto-Oncogene, Src Family Tyrosine Kinase

gene · 1196 words

Tau Kinase Signaling Cascade in Alzheimer's Disease

mechanism · 3059 words

LCK Protein (Lymphocyte-Specific Protein Tyrosine Kinase)

protein · 2373 words

SRC Protein (SRC Proto-Oncogene)

protein · 2125 words

FLOT1 Protein (Flotillin-1)

protein · 1629 words

PTPRC Protein - Protein Tyrosine Phosphatase Receptor Type C

protein · 1297 words

Pathway Diagram

graph TD
    LCK["<b>LCK</b>"]
    Ms{"Ms"}
    LCK -->|"activates"| Ms
    Leukemia{"Leukemia"}
    LCK -->|"therapeutic target"| Leukemia
    Als{"Als"}
    LCK -->|"therapeutic target"| Als
    LCK -->|"therapeutic target"| Ms
    LCK -->|"regulates"| Ms
    Autism{"Autism"}
    LCK -->|"regulates"| Autism
    Parkinson{"Parkinson"}
    LCK -->|"activates"| Parkinson
    LCK -->|"expressed in"| Ms
    FYN["FYN"]
    LCK -->|"activates"| FYN
    SRC["SRC"]
    LCK -->|"activates"| SRC
    Mapk(["Mapk"])
    LCK -->|"interacts with"| Mapk
    Apoptosis(["Apoptosis"])
    LCK -->|"activates"| Apoptosis
    SRC -->|"activates"| LCK
    FYN -->|"activates"| LCK
    BCL2["BCL2"]
    BCL2 -->|"therapeutic target"| LCK
    CD4["CD4"]
    CD4 -->|"interacts with"| LCK
    MAPK3["MAPK3"]
    MAPK3 -->|"interacts with"| LCK
    ZAP70["ZAP70"]
    ZAP70 -->|"interacts with"| LCK
    TP53["TP53"]
    TP53 -->|"interacts with"| LCK
    MIRNAS["MIRNAS"]
    MIRNAS -->|"regulates"| LCK
    CD19["CD19"]
    CD19 -->|"interacts with"| LCK
    EEF2["EEF2"]
    EEF2 -->|"interacts with"| LCK
    CCL5["CCL5"]
    CCL5 -->|"interacts with"| LCK
    TNF["TNF"]
    TNF -->|"interacts with"| LCK
    style LCK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (22)

TargetRelationTypeStr
Msactivatesdisease0.65
Leukemiatherapeutic_targetdisease0.65
Alstherapeutic_targetdisease0.65
Mstherapeutic_targetdisease0.65
Msregulatesdisease0.65

Incoming (45)

SourceRelationTypeStr
P62associated_withgene0.70
SRCactivatesgene0.60
FYNactivatesgene0.60
BCL2therapeutic_targetgene0.60
CD4interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found