Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GPX4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GPX4 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with ALS, Aging, Als. Connected to 949 entities in the SciDEX knowledge graph.
| Gene Symbol | GPX4 |
| Full Name | Glutathione Peroxidase 4 |
| Chromosome | 19p13.3 |
| Protein Type | Enzyme |
| Target Class | Enzyme |
| Function | GPX4 serves as the primary defense against lipid peroxidation in cellular membranes |
| Mechanism of Action | Small molecule inhibitor or activator of peroxidase activity |
| Druggability | Low (0.41) |
| Clinical Stage | Phase II |
| Molecular Weight | 22 kDa |
| Pathways | Akt, Apoptosis, Autophagy, Differentiation, Epigenetic |
| UniProt ID | P36969 |
| Ensembl ID | ENSG00000167468 |
| GeneCards | GPX4 |
| Human Protein Atlas | GPX4 |
| Associated Diseases | ALS, ALZHEIMER'S DISEASE, Alzheimer, Cancer, Carcinoma |
| Known Drugs/Compounds | NICOTINAMIDE, TEMOZOLOMIDE, N-ACETYLCYSTEINE, icariin, paricalcitol, curcumin |
| Interactions | SLC7A11, SOX9, MMP1, FER, TFR1, MLKL |
| SciDEX Target | View Target Profile (10 clinical trials) |
| SciDEX Hypotheses | Ferroptosis Inhibition for α-Synuclein Neuroprotec |
| KG Connections | 2167 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GPX4["GPX4"] -->|"associated"| neurodegeneration["neurodegeneration"]
GPX4["GPX4"] -->|"interacts"| SLC7A11["SLC7A11"]
GPX4["GPX4"] -->|"co discussed"| PLA2G6["PLA2G6"]
GPX4["GPX4"] -->|"co discussed"| MMP2["MMP2"]
GPX4["GPX4"] -->|"co discussed"| C3["C3"]
GPX4["GPX4"] -->|"co discussed"| PLA2G4A["PLA2G4A"]
SLC7A11_1["SLC7A11"] -->|"interacts"| GPX4["GPX4"]
MMP9["MMP9"] -->|"co discussed"| GPX4["GPX4"]
SLC7A11_2["SLC7A11"] -->|"co discussed"| GPX4["GPX4"]
AQP4["AQP4"] -->|"co discussed"| GPX4["GPX4"]
style GPX4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ferroptosis | inhibits | phenotype | 1.00 |
| STING | activates | protein | 1.00 |
| NRF2 | activates | gene | 1.00 |
| NRF2 | inhibits | gene | 1.00 |
| FERROPTOSIS | inhibits | pathway | 1.00 |
| Als | inhibits | disease | 1.00 |
| Ferroptosis | inhibits | pathway | 1.00 |
| Ferroptosis | activates | pathway | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Ferroptosis | regulates | pathway | 1.00 |
| CANCER | activates | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| Als | regulates | disease | 1.00 |
| FERROPTOSIS | regulates | gene | 1.00 |
| FERROPTOSIS | activates | gene | 1.00 |
| ROS | inhibits | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| Oxidative Stress | regulates | pathway | 1.00 |
| Inflammation | activates | disease | 0.95 |
| lipid peroxidation | inhibits | phenotype | 0.90 |
| redox homeostasis | regulates | phenotype | 0.90 |
| Lipid Peroxidation | catalyzes | process | 0.90 |
| ferroptosis | prevents | process | 0.90 |
| Chondrocyte Ferroptosis | inhibits | process | 0.90 |
| CHRONIC KIDNEY DISEASE | protects_against | disease | 0.90 |
| ferroptosis | participates_in | pathway | 0.90 |
| TFR1 | co_mentioned_with | gene | 0.90 |
| SLC7A11 | co_mentioned_with | gene | 0.90 |
| glutathione-dependent lipid peroxidation | mediates | process | 0.90 |
| Ferroptosis | involved_in | process | 0.90 |
| unfolded protein response | participates_in | pathway | 0.90 |
| oxidative stress response | participates_in | pathway | 0.90 |
| autophagy pathway | participates_in | pathway | 0.90 |
| Autophagy | regulates | pathway | 0.90 |
| Autophagy | associated_with | pathway | 0.90 |
| Apoptosis | activates | pathway | 0.90 |
| P53 | activates | gene | 0.90 |
| GENES | inhibits | gene | 0.90 |
| Apoptosis | inhibits | pathway | 0.90 |
| Oxidative Stress | inhibits | pathway | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SLC7A11 | regulates | gene | 1.00 |
| SLC7A11 | activates | gene | 1.00 |
| SLC7A11 | inhibits | gene | 1.00 |
| TMEM16F | regulates | gene | 1.00 |
| NRF2 | upregulates | protein | 0.95 |
| copper | binds_to | drug | 0.95 |
| STING | targets | protein | 0.95 |
| HNRNPA2B1 | associated_with | protein | 0.93 |
| Emodin | downregulates | drug | 0.92 |
| Lactoferrin | upregulates | protein | 0.91 |
| STING | inhibits | protein | 0.90 |
| ZDHHC8 | modifies | protein | 0.90 |
| MIR130B | upregulates | gene | 0.90 |
| Rotenone | downregulates | compound | 0.90 |
| HSP90 | interacts_with | protein | 0.90 |
| TAX1BP1 | modulates | protein | 0.90 |
| autophagy | degrades | process | 0.90 |
| Thonningianin A | activates | chemical | 0.90 |
| NFE2L2 | upregulates | gene | 0.90 |
| ACSL4 | co_mentioned_with | gene | 0.90 |
| Klebsiella Pneumoniae | downregulates | disease | 0.90 |
| GSH | activates | protein | 0.90 |
| TRIM34 | upregulates | gene | 0.90 |
| h-7957bb2a | targets_gene | hypothesis | 0.90 |
| h-2c776894 | targets_gene | hypothesis | 0.90 |
| AUTOPHAGY | mediates | process | 0.89 |
| UBIQUITIN | mediates | entity | 0.88 |
| Ncoa4 Knockdown | upregulates | mechanism | 0.88 |
| KAEMPFEROL | upregulates | drug | 0.88 |
| Nonsense-Mediated Decay | regulates | pathway | 0.87 |
| Hnrnpa2B1 | upregulates | protein | 0.87 |
| Autophagy | mediates | process | 0.87 |
| HSC70 | binds | protein | 0.87 |
| Klebsiella pneumoniae | downregulates | disease | 0.85 |
| THBS1 | associated_with | protein | 0.85 |
| UBIQUITIN | modulates | protein | 0.85 |
| HSP90 | promotes | protein | 0.85 |
| INTERLEUKIN-1 BETA | downregulates | protein | 0.85 |
| Paricalcitol | upregulates | drug | 0.85 |
| copper | upstream_of | drug | 0.85 |
| STING | upstream_of | protein | 0.85 |
| ACSL4 | opposed_by | gene | 0.85 |
| UPF1 | regulates | protein | 0.85 |
| Lactoferrin | correlates_with | protein | 0.85 |
| Montelukast | upregulates | drug | 0.85 |
| Chronic cerebral hypoperfusion | inhibits | process | 0.85 |
| Cadmium | downregulates | compound | 0.85 |
| BDNF | upregulates | gene | 0.85 |
| 116B | upregulates | compound | 0.85 |
| chaperone-mediated autophagy | inhibits | pathway | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Ferroptosis Inhibition for α-Synuclein Neuroprotection | 0.548 | neurodegeneration | Gene expression changes in aging mouse b |
Scientific analyses that reference this entity
immunology | 2026-04-15 | 0 hypotheses
neurodegeneration | 2026-04-03 | 34 hypotheses Top: 0.692
neurodegeneration | 2026-04-03 | 17 hypotheses Top: 0.662
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.570
neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Targeting the SCP2/HSPB1 Axis: A Novel Mechanism Underlying Ferroptosis Regulati [PMID:40993092] | Jiang H, Hu W, Yuan L | Tohoku J Exp Med | 2026 | 0 |
| GPX4 promotes optic nerve regeneration and retinal ganglion cell neuroprotection [PMID:41485051] | Yang M, Bian F, Feng X, Li L, Huang H et | Mol Ther | 2026 | 0 |
| Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors. [PMID:41494530] | Liu J, Cai X, Lin J, Zhang Z, Zhou Q et | Cell | 2026 | 0 |
| Aging at the Crossroads of Cuproptosis and Ferroptosis: From Molecular Pathways [PMID:41516398] | Gromadzka G, Tarnacka B, Cieślik M | Int J Mol Sci | 2026 | 0 |
| Ferroptosis in neurological diseases: moving towards therapeutic intervention. [PMID:41554903] | Tuo QZ, Bush AI, Lei P | Mol Psychiatry | 2026 | 0 |
| Fin(e)-tuning ferroptosis. [PMID:41576911] | Szylo KJ, Dixon SJ | Mol Cell | 2026 | 0 |
| GPX4-dependent ferroptosis governs ILC2 homeostasis and colitis progression. [PMID:41663525] | Liu G, Wang Y, Huang H, Wang J, Yang J e | Cell Mol Immunol | 2026 | 0 |
| A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth s [PMID:41720096] | Xia Z, Yang X, Samovich SN, Tyurina YY, | Cell | 2026 | 0 |
| The crossroads of inflammation and oxidative stress: A review of the interplay b [PMID:41722697] | Park WH | Pharmacol Res | 2026 | 0 |
| Ferroptosis in Cerebral Ischemia/Reperfusion Injury: Mechanistic Drivers and The [PMID:41738060] | Song C, Liu Z, Tang J, Huang Y | Neuropsychiatr Dis Treat | 2026 | 0 |
| Decoding GPX4 regulation in ferroptosis: mechanisms and therapeutic implications [PMID:41826143] | Chen X | Trends Mol Med | 2026 | 0 |
| 4-Octyl itaconate attenuates radiation-induced intestinal injury associated with [PMID:41936917] | Zhang S, Yue T, Jin P, Zhang X, Huo Q et | Free Radic Biol Med | 2026 | 0 |
| Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013] | Gu X, Sun F, Li Y, Yang S, Li Y | Int J Biol Macromol | 2026 | 0 |
| Co-Delivery of Ferrostatin-1 and M2 Macrophage-Derived Exosomal Signals via Engi [PMID:41944411] | Hao W, Sun N, Xue R, Chang J, Pang X et | ACS Appl Mater Interfaces | 2026 | 0 |
| Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell [PMID:41945797] | Zhang Y, Wang X, Wu Y, Liu L, Nuerlan G | Adv Sci (Weinh) | 2026 | 0 |
| Ferroptosis-related mechanisms in prion diseases provide insights into neurodege [PMID:41945998] | Zayed M, Tayara H, Jeong BH | Redox Biol | 2026 | 0 |
| [The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579] | Wu K, Wang N, Zhao D, Wei W, Zhang W et | Zhejiang Da Xue Xue Bao Yi Xue | 2026 | 0 |
| Isorhamnetin-preconditioned MSC-derived exosomes restore ovarian function by inh [PMID:41947243] | Zhang Q, Yu J, Zheng Y, Jiang J, Zheng L | Stem Cell Res Ther | 2026 | 0 |
| NOX4 mediates ferroptosis through oxidative stress in diabetic keratopathy. [PMID:41951167] | Wang X, Wang Y, Zhao X, Yu X, Qu Y et al | Exp Eye Res | 2026 | 0 |
| Targeting NDUFS4 Disrupts Oxidative Phosphorylation and Induces Ferroptosis in O [PMID:41954274] | Schaaf ZA, Ning S, Leslie AR, Sharifi M, | Mol Cancer Ther | 2026 | 0 |