Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FNDC5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | FNDC5 |
| Full Name | Fibronectin Type III Domain Containing 5 |
| Chromosome | 1p36.22 |
| Function | is a gene located on chromosome 1p36. |
| Primary Expression | Skeletal muscle (primary), hippocampus, cortex, heart |
| Amino Acids | 112 aa |
| Pathways | Dna Repair, Dopamine Pathways, Inflammasome, Mapk, Mitophagy |
| UniProt ID | Q8IZF6 |
| NCBI Gene ID | 56852 |
| Ensembl ID | ENSG00000100597 |
| GeneCards | FNDC5 |
| Human Protein Atlas | FNDC5 |
| Protein Product | FNDC5/Irisin |
| Related Diseases | Alzheimer's Disease, Parkinson's Disease, ALS, Type 2 Diabetes |
| Associated Diseases | Alzheimer, Alzheimer'S Disease, Ataxia, DIABETES |
| Interactions | PLAU, CXCL10, CX3CL1, VIM, BDNF, FGF23 |
| KG Connections | 277 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
FNDC5["FNDC5"] -->|"encodes"| irisin["irisin"]
FNDC5["FNDC5"] -->|"biomarker for"| Inflammation["Inflammation"]
FNDC5["FNDC5"] -->|"biomarker for"| Senescence["Senescence"]
FNDC5["FNDC5"] -->|"biomarker for"| Als["Als"]
FNDC5["FNDC5"] -->|"biomarker for"| Aging["Aging"]
FNDC5["FNDC5"] -->|"biomarker for"| Longevity["Longevity"]
FNDC5["FNDC5"] -->|"biomarker for"| Fibrosis["Fibrosis"]
FNDC5["FNDC5"] -->|"activates"| Fibrosis["Fibrosis"]
FNDC5["FNDC5"] -->|"regulates"| Cancer["Cancer"]
FNDC5["FNDC5"] -->|"expressed in"| Als["Als"]
FNDC5["FNDC5"] -->|"associated with"| Ataxia["Ataxia"]
FNDC5["FNDC5"] -->|"therapeutic target"| Cardiac["Cardiac"]
style FNDC5 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style irisin fill:#006494,stroke:#333,color:#e0e0e0
style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
style Senescence fill:#ef5350,stroke:#333,color:#e0e0e0
style Als fill:#ef5350,stroke:#333,color:#e0e0e0
style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
style Longevity fill:#ef5350,stroke:#333,color:#e0e0e0
style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
style Ataxia fill:#ef5350,stroke:#333,color:#e0e0e0
style Cardiac fill:#ef5350,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| IRISIN | encodes | protein | 1.00 |
| Fracture Healing | associated_with | process | 0.95 |
| Frailty | biomarker_for | phenotype | 0.95 |
| Osteogenesis | associated_with | process | 0.90 |
| BDNF | upregulates | protein | 0.90 |
| Angiogenesis | associated_with | process | 0.90 |
| Alzheimer'S Disease | protects_against | disease | 0.90 |
| Oxidative Stress | associated_with | process | 0.90 |
| Neuroinflammation | associated_with | process | 0.90 |
| MITOCHONDRIA | associated_with | cell_type | 0.85 |
| NFKB | inhibits | protein | 0.85 |
| Neurodegeneration | protects_against | disease | 0.85 |
| Oxidative Stress | suppresses | process | 0.85 |
| Depression | protects_against | disease | 0.82 |
| Dopamine | upregulates | compound | 0.80 |
| Dopamine Pathways | regulates | pathway | 0.80 |
| Muscle-Bone-Brain Axis | mediates | pathway | 0.80 |
| synaptic plasticity | promotes | process | 0.80 |
| EXERCISE | activates | gene | 0.80 |
| Inflammation | activates | disease | 0.75 |
| Als | activates | disease | 0.75 |
| irisin | encodes | protein | 0.70 |
| Oxidative Stress | activates | pathway | 0.70 |
| Inflammation | biomarker_for | disease | 0.65 |
| Senescence | biomarker_for | disease | 0.65 |
| Als | biomarker_for | disease | 0.65 |
| Aging | biomarker_for | disease | 0.65 |
| Longevity | biomarker_for | disease | 0.65 |
| Fibrosis | biomarker_for | disease | 0.65 |
| Fibrosis | activates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Ataxia | associated_with | disease | 0.65 |
| Cardiac | therapeutic_target | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| ALS | biomarker_for | disease | 0.65 |
| Diabetes | activates | disease | 0.65 |
| Epilepsy | activates | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Obesity | activates | disease | 0.65 |
| Type 2 Diabetes | activates | disease | 0.65 |
| Insulin Resistance | activates | disease | 0.65 |
| Aging | inhibits | disease | 0.65 |
| Alzheimer | inhibits | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Obesity | associated_with | disease | 0.65 |
| Depression | inhibits | disease | 0.65 |
| Diabetes | associated_with | disease | 0.65 |
| ALS | inhibits | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Exercise | upregulates | process | 0.90 |
| Muscle | expressed_in | entity | 0.85 |
| BDNF | activates | gene | 0.70 |
| FGF21 | activates | gene | 0.60 |
| APP | biomarker_for | gene | 0.60 |
| CXCL10 | activates | gene | 0.60 |
| PLAU | activates | gene | 0.60 |
| FGF23 | activates | gene | 0.60 |
| GPNMB | biomarker_for | gene | 0.60 |
| C1Q | biomarker_for | gene | 0.60 |
| CX3CL1 | activates | gene | 0.60 |
| VIM | activates | gene | 0.60 |
| S100B | biomarker_for | gene | 0.60 |
| ATR | activates | gene | 0.60 |
| BAX | activates | gene | 0.60 |
| PROGRANULIN | activates | gene | 0.60 |
| HMGB1 | biomarker_for | gene | 0.60 |
| TGM2 | biomarker_for | gene | 0.60 |
| VIMENTIN | activates | gene | 0.60 |
| SDHA | activates | gene | 0.60 |
| MFN2 | activates | gene | 0.60 |
| SOD2 | activates | gene | 0.60 |
| NRF2 | activates | gene | 0.60 |
| NEPRILYSIN | inhibits | gene | 0.60 |
| BDNF | inhibits | gene | 0.60 |
| SOD1 | activates | gene | 0.60 |
| GENES | biomarker_for | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| APOPTOSIS | biomarker_for | gene | 0.60 |
| AMYLOID | biomarker_for | gene | 0.60 |
| INFLAMMATION | biomarker_for | gene | 0.60 |
| COMPLEMENT | biomarker_for | gene | 0.60 |
| AGING | biomarker_for | gene | 0.60 |
| MITOCHONDRIA | biomarker_for | gene | 0.60 |
| GHRL | biomarker_for | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 0.60 |
| ASTROCYTES | inhibits | gene | 0.60 |
| ALZHEIMER'S DISEASE | inhibits | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| EXERCISE | activates | gene | 0.60 |
| IGF-1 | biomarker_for | gene | 0.60 |
| EXERCISE | associated_with | gene | 0.60 |
| INFLAMMATION | inhibits | gene | 0.60 |
| COMPLEMENT | inhibits | gene | 0.60 |
| INSULIN RESISTANCE | inhibits | gene | 0.60 |
| PGRN | activates | gene | 0.60 |
| IL-6 | activates | gene | 0.60 |
| NEP | inhibits | gene | 0.60 |
| ALZHEIMER | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||