gene

FNDC5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FNDC5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

277Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

Page for FNDC5 — Fibronectin Type III Domain Containing 5

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🧬 Gene Info
Gene SymbolFNDC5
Full NameFibronectin Type III Domain Containing 5
Chromosome1p36.22
Functionis a gene located on chromosome 1p36.
Primary ExpressionSkeletal muscle (primary), hippocampus, cortex, heart
Amino Acids112 aa
PathwaysDna Repair, Dopamine Pathways, Inflammasome, Mapk, Mitophagy
UniProt IDQ8IZF6
NCBI Gene ID56852
Ensembl IDENSG00000100597
GeneCardsFNDC5
Human Protein AtlasFNDC5
Protein ProductFNDC5/Irisin
Related DiseasesAlzheimer's Disease, Parkinson's Disease, ALS, Type 2 Diabetes
Associated DiseasesAlzheimer, Alzheimer'S Disease, Ataxia, DIABETES
InteractionsPLAU, CXCL10, CX3CL1, VIM, BDNF, FGF23
KG Connections277 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: FNDC5 — AlphaFold Q8IZF6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Canonical Page

FNDC5 — Fibronectin Type III Domain Containing 5

gene · 918 words

CBS/PSP Treatment Rankings

therapeutic · 5434 words

IGF-1 Signaling Pathway in Neurodegeneration

mechanism · 3993 words

AMPK Signaling Pathway

mechanism · 3031 words

Irisin (FNDC5) - Exercise-Induced Myokine for Neurodegeneration

mechanism · 2962 words

Exercise-BDNF-Mitochondrial Resilience Hypothesis

hypothesis · 2936 words

Pathway Diagram

flowchart TD
    FNDC5["FNDC5"] -->|"encodes"| irisin["irisin"]
    FNDC5["FNDC5"] -->|"biomarker for"| Inflammation["Inflammation"]
    FNDC5["FNDC5"] -->|"biomarker for"| Senescence["Senescence"]
    FNDC5["FNDC5"] -->|"biomarker for"| Als["Als"]
    FNDC5["FNDC5"] -->|"biomarker for"| Aging["Aging"]
    FNDC5["FNDC5"] -->|"biomarker for"| Longevity["Longevity"]
    FNDC5["FNDC5"] -->|"biomarker for"| Fibrosis["Fibrosis"]
    FNDC5["FNDC5"] -->|"activates"| Fibrosis["Fibrosis"]
    FNDC5["FNDC5"] -->|"regulates"| Cancer["Cancer"]
    FNDC5["FNDC5"] -->|"expressed in"| Als["Als"]
    FNDC5["FNDC5"] -->|"associated with"| Ataxia["Ataxia"]
    FNDC5["FNDC5"] -->|"therapeutic target"| Cardiac["Cardiac"]
    style FNDC5 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style irisin fill:#006494,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Senescence fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
    style Longevity fill:#ef5350,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ataxia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiac fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (209)

TargetRelationTypeStr
IRISINencodesprotein1.00
Fracture Healingassociated_withprocess0.95
Frailtybiomarker_forphenotype0.95
Osteogenesisassociated_withprocess0.90
BDNFupregulatesprotein0.90

Incoming (68)

SourceRelationTypeStr
Exerciseupregulatesprocess0.90
Muscleexpressed_inentity0.85
BDNFactivatesgene0.70
FGF21activatesgene0.60
APPbiomarker_forgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found