concept

ACE2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACE2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

88Connections

0Hypotheses

0Analyses

50Outgoing

18Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ACE2
Key Genes/Proteins	FGF21
Related Diseases	Sars-Cov-2, Ms, Als, ALS, Alzheimer
Related Pathways	Counter-regulatory Renin-Angiotensin System

Wiki Pages (13)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ACE2["ACE2"]
    ACE2 -->|"targets"| SARS_CoV_2["SARS-CoV-2"]
    ACE2 -->|"binds_to"| SARS_COV_2["SARS-COV-2"]
    ACE2 -->|"targets"| Sars_Cov_2["Sars-Cov-2"]
    ACE2 -->|"binds"| Sars_Cov_2_Receptor_Binding_Do["Sars-Cov-2 Receptor Binding Domain"]
    ACE2 -->|"participates in"| Counter_regulatory_Renin_Angio["Counter-regulatory Renin-Angiotensin System"]
    ACE2 -.protects against.-> Ms["Ms"]
    SARS_CoV_2 -->|"binds"| ACE2
    FCGRT["FCGRT"] -.protects against.-> ACE2
    NEP["NEP"] -->|"activates"| ACE2
    APOPTOSIS["APOPTOSIS"] -->|"activates"| ACE2
    ALZHEIMER["ALZHEIMER"] -->|"activates"| ACE2
    NEPRILYSIN["NEPRILYSIN"] -->|"activates"| ACE2
    TAU["TAU"] -->|"activates"| ACE2
    NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| ACE2

Outgoing (70)

Target	Relation	Type	Str
SARS-COV-2	binds_to	entity	0.90
Sars-Cov-2	targets	disease	0.90
SARS-CoV-2	binds	entity	0.90
Sars-Cov-2 Receptor Binding Domain	binds	compound	0.85
Counter-regulatory Renin-Angiotensin System	participates_in	pathway	0.80
Ang II	converts_to	compound	0.80
Ang-(1-7)	produces	compound	0.80
Ms	protects_against	disease	0.65
Als	protects_against	disease	0.65
ALS	protects_against	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	causes	disease	0.65
Aging	causes	disease	0.65
Diabetes	causes	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	inhibits	disease	0.65
Als	associated_with	disease	0.65
Diabetes	inhibits	disease	0.65
AND	protects_against	gene	0.60
TMPRSS2	protects_against	gene	0.60
FCGRT	protects_against	gene	0.60
IDE	activates	gene	0.60
Apoptosis	activates	pathway	0.60
CTSD	associated_with	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
TAU	activates	gene	0.60
Neuroinflammatory	activates	pathway	0.60
Amyloid	associated_with	pathway	0.60
AMYLOID	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
NEP	activates	gene	0.60
NEPRILYSIN	activates	gene	0.60
Aβ	activates	protein	0.60
Insulin	activates	protein	0.60
APOE4	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
Inflammasome	interacts_with	pathway	0.60
Immune Response	interacts_with	pathway	0.60
Rb	protects_against	protein	0.60
Raf	associated_with	protein	0.60
FCGRT	interacts_with	gene	0.60
SARS	interacts_with	gene	0.60
TMPRSS2	interacts_with	gene	0.60
FCGRT	activates	gene	0.60
SARS	activates	gene	0.60
TMPRSS2	activates	gene	0.60
SARS	regulates	gene	0.60
IDE	associated_with	gene	0.60

Incoming (18)

Source	Relation	Type	Str
FGF21	interacts_with	gene	0.80
FCGRT	protects_against	gene	0.60
NEP	activates	gene	0.60
AMYLOID	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
NEPRILYSIN	activates	gene	0.60
TAU	activates	gene	0.60
HMOX1	associated_with	gene	0.60
FGF21	associated_with	gene	0.60
LPL	associated_with	gene	0.60
ALDH1A1	associated_with	gene	0.60
GUSB	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
SARS	inhibits	gene	0.60
APOE	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
SARS	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ACE2

Understanding Entity Pages

Wiki Pages (13)

Infectious Triggers in Alzheimer's Disease

viral-post-infectious-als

post-covid-neurological-syndrome

Post-Acute Viral Reservoir Hypothesis in Parkinson's Disease

renin-angiotensin-system

Neurovascular-Gut-Brain Axis in Neurodegeneration Synthesis

COVID-19 Neurodegeneration Mechanism

ACE Protein

Mas Receptor Agonists for Neurodegeneration

EMD — Emerin

ACE Gene