concept

CHAC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHAC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

58Connections

0Hypotheses

0Analyses

30Outgoing

25Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	CHAC1
Key Genes/Proteins	CANCER, FER, PTGS2, SLC7A11, ACSL4, FERROPTOSIS
Related Diseases	Cancer, Als
Related Pathways	Ferroptosis, Oxidative Stress

Wiki Pages (2)

Knowledge base pages for this entity

Ferroptosis

entity · 2823 words

→

VPS13 Lipid Transport and Organelle Contact Site Modulation Therapy

idea · 1517 words

→

Pathway Diagram

graph TD
    CHAC1["CHAC1"]
    CHAC1 -->|"activates"| Cancer["Cancer"]
    CHAC1 -->|"activates"| Als["Als"]
    CHAC1 -->|"activates"| CANCER["CANCER"]
    CHAC1 -->|"activates"| FER["FER"]
    CHAC1 -->|"activates"| Ferroptosis["Ferroptosis"]
    CHAC1 -->|"expressed in"| PTGS2["PTGS2"]
    CHAC1 -->|"expressed in"| SLC7A11["SLC7A11"]
    CHAC1 -->|"expressed in"| ACSL4["ACSL4"]
    TMEM16F["TMEM16F"] -->|"regulates"| CHAC1
    ALOX12["ALOX12"] -->|"activates"| CHAC1
    GENES["GENES"] -->|"activates"| CHAC1
    HMOX1["HMOX1"] -->|"activates"| CHAC1
    NFE2L2["NFE2L2"] -->|"activates"| CHAC1
    FERROPTOSIS["FERROPTOSIS"] -->|"activates"| CHAC1
    ALOX15["ALOX15"] -->|"activates"| CHAC1
    ALOX5["ALOX5"] -->|"activates"| CHAC1

Outgoing (31)

Target	Relation	Type	Str
ferroptosis	promotes	process	0.80
Cancer	activates	disease	0.65
Als	activates	disease	0.65
CANCER	activates	gene	0.60
FER	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
PTGS2	expressed_in	gene	0.60
SLC7A11	expressed_in	gene	0.60
ACSL4	expressed_in	gene	0.60
FERROPTOSIS	interacts_with	gene	0.60
P53	expressed_in	gene	0.60
Oxidative Stress	interacts_with	pathway	0.60
Ferroptosis	interacts_with	pathway	0.60
ALOX15	activates	gene	0.60
NFE2L2	activates	gene	0.60
ALOXE3	activates	gene	0.60
ALOX12	activates	gene	0.60
ALOX5	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
SAT1	activates	gene	0.60
RNA	activates	gene	0.60
AND	activates	gene	0.60
GENES	activates	gene	0.60
GSH	activates	gene	0.60
Ras	activates	protein	0.60
HERC5	activates	gene	0.60
Apoptosis	activates	pathway	0.60
Caspase	activates	protein	0.60
ferroptosis	participates_in	pathway	0.60
ferroptosis	activates	process	0.60

Incoming (27)

Source	Relation	Type	Str
ALOX12	activates	gene	0.60
GENES	activates	gene	0.60
HMOX1	activates	gene	0.60
NFE2L2	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
ALOX15	activates	gene	0.60
ALOX5	activates	gene	0.60
GPX4	expressed_in	gene	0.60
FTH1	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
OXIDATIVE STRESS	interacts_with	gene	0.60
CANCER	activates	gene	0.60
ALOXE3	activates	gene	0.60
FER	activates	gene	0.60
AND	activates	gene	0.60
RNA	activates	gene	0.60
GSH	activates	gene	0.60
SAT1	activates	gene	0.60
ISG15	activates	gene	0.60
CMPK2	activates	gene	0.60
SNAP23	activates	gene	0.60
ZBP1	activates	gene	0.60
RFK	activates	gene	0.60
BAX	activates	gene	0.60
APOPTOSIS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found