Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about P16INK4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | P16INK4A |
| Key Genes/Proteins | GENES, ALZHEIMER, P21CIP1, FAS, INFLAMMATION |
| Related Diseases | Aging, Obesity, Inflammation, Diabetes, Alzheimer |
Knowledge base pages for this entity
graph TD
P16INK4A["P16INK4A"]
P16INK4A -->|"activates"| senescence["senescence"]
P16INK4A -->|"regulates"| Aging["Aging"]
P16INK4A -->|"regulates"| Obesity["Obesity"]
P16INK4A -->|"regulates"| Inflammation["Inflammation"]
P16INK4A -->|"regulates"| Diabetes["Diabetes"]
P16INK4A -->|"regulates"| Alzheimer["Alzheimer"]
P16INK4A -->|"regulates"| ALS["ALS"]
P16INK4A -.biomarker for.-> Senescence["Senescence"]
GSK3B["GSK3B"] -->|"binds"| P16INK4A
RB1["RB1"] -->|"regulates"| P16INK4A
APOPTOSIS["APOPTOSIS"] -.biomarker for.-> P16INK4A
ALZHEIMER["ALZHEIMER"] -->|"regulates"| P16INK4A
GENES["GENES"] -->|"regulates"| P16INK4A
BCL2L1["BCL2L1"] -.biomarker for.-> P16INK4A
CDKN2A["CDKN2A"] -->|"activates"| P16INK4A
TP53["TP53"] -->|"activates"| P16INK4A| Target | Relation | Type | Str |
|---|---|---|---|
| Aging | regulates | disease | 0.65 |
| Obesity | regulates | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| Diabetes | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| Senescence | biomarker_for | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Ataxia | activates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| GENES | regulates | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| P21CIP1 | biomarker_for | gene | 0.60 |
| FAS | regulates | gene | 0.60 |
| INFLAMMATION | regulates | gene | 0.60 |
| BCL2L1 | biomarker_for | gene | 0.60 |
| BAK1 | biomarker_for | gene | 0.60 |
| MMP1 | regulates | gene | 0.60 |
| AGING | regulates | gene | 0.60 |
| Apoptosis | biomarker_for | pathway | 0.60 |
| APOPTOSIS | biomarker_for | gene | 0.60 |
| DNA | activates | gene | 0.60 |
| ATM | activates | gene | 0.60 |
| Dna Repair | activates | pathway | 0.60 |
| AND | biomarker_for | gene | 0.60 |
| T Cell | regulates | cell_type | 0.60 |
| Rb | regulates | protein | 0.60 |
| App | regulates | protein | 0.60 |
| Ras | regulates | protein | 0.60 |
| P21 | biomarker_for | protein | 0.60 |
| T Cell | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOPTOSIS | biomarker_for | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| BCL2L1 | biomarker_for | gene | 0.60 |
| CDKN2A | activates | gene | 0.60 |
| TP53 | activates | gene | 0.60 |
| P53 | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| P21CIP1 | biomarker_for | gene | 0.60 |
| AGING | regulates | gene | 0.60 |
| INFLAMMATION | regulates | gene | 0.60 |
| FAS | regulates | gene | 0.60 |
| MMP1 | regulates | gene | 0.60 |
| BAK1 | biomarker_for | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||