| Gene Symbol | PERK |
| Protein Type | Kinase |
| Function | Stress sensing: Accumulation of unfolded proteins in the ER lumen |
| Subcellular Localization | the ER membrane. As one of the three major sensors of the unfolded protein response (UPR) |
| Molecular Weight | 125 kDa |
| GeneCards | PERK |
| Human Protein Atlas | PERK |
| Interactor | Relationship |
| BiP/GRP78 | Inhibitory binding partner |
| [eIF2α](/proteins/eif2a) | Phosphorylation substrate |
| ATF4 | Downstream transcription factor |
| CHOP | ATF4 target |
| GADD34 | Phosphatase regulator |
| Nrf2 | PERK phosphorylates |
| FoxO1 | PERK phosphorylates |
| Associated Diseases | AD, ALI, ALS, Aging, Alzheimer |
| Known Drugs/Compounds | rapamycin, Dolutegravir, SB202190, DTG |
| Interactions | MAP1LC3B, BECN1, RHOT1, STING1, LC3, MAPK8 |
| KG Connections | 878 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |