gene

SELF-DNA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SELF-DNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

153Connections

0Hypotheses

0Analyses

50Outgoing

43Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	SELF
Pathways	Innate Immunity, Immune Response, Pyroptosis, Inflammasome, Cell Division
GeneCards	SELF
Human Protein Atlas	SELF
Associated Diseases	Amyotrophic Lateral Sclerosis, Autoimmune, Cancer, Inflammation, Ms
Interactions	CGAS, GENES, STING, DNA, IFN, CGAS-STING
KG Connections	149 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (7)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SELF_DNA["SELF-DNA"] -->|"activates"| GENES["GENES"]
    SELF_DNA["SELF-DNA"] -->|"regulates"| Inflammation["Inflammation"]
    SELF_DNA["SELF-DNA"] -->|"activates"| Inflammation_1["Inflammation"]
    SELF_DNA["SELF-DNA"] -->|"activates"| CGAS["CGAS"]
    SELF_DNA["SELF-DNA"] -->|"associated"| CGAS_2["CGAS"]
    SELF_DNA["SELF-DNA"] -->|"activates"| Innate_Immunity["Innate Immunity"]
    AGING["AGING"] -->|"therapeutic target"| SELF_DNA["SELF-DNA"]
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"therapeutic target"| SELF_DNA["SELF-DNA"]
    NEURODEGENERATION["NEURODEGENERATION"] -->|"therapeutic target"| SELF_DNA["SELF-DNA"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"therapeutic target"| SELF_DNA["SELF-DNA"]
    style SELF_DNA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (109)

Target	Relation	Type	Str
GENES	activates	gene	0.80
Inflammation	regulates	disease	0.75
Inflammation	activates	disease	0.75
CGAS	activates	gene	0.70
CGAS	associated_with	gene	0.70
Innate Immunity	activates	pathway	0.70
STING	activates	gene	0.70
INFLAMMATION	regulates	gene	0.70
DNA	regulates	gene	0.70
Inflammation	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Senescence	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Als	inhibits	disease	0.65
Infection	regulates	disease	0.65
Als	regulates	disease	0.65
Cancer	implicated_in	disease	0.65
Inflammation	implicated_in	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Aging	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Autoimmune	associated_with	disease	0.65
Infection	activates	disease	0.65
Inflammation	causes	disease	0.65
Ms	causes	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Alzheimer	activates	disease	0.65
Parkinson	activates	disease	0.65
Senescence	activates	disease	0.65
Immune Response	therapeutic_target	pathway	0.60
PARKINSON	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
AGING	therapeutic_target	gene	0.60
DNA	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
CGAS-STING	therapeutic_target	gene	0.60
IFN	activates	gene	0.60

Incoming (44)

Source	Relation	Type	Str
AGING	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
CGAS-STING	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
STING	activates	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
INFLAMMATION	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
CGAS-STING	associated_with	gene	0.60
STING	associated_with	gene	0.60
TNFAIP3	activates	gene	0.60
NEK7	inhibits	gene	0.60
NLRP3	activates	gene	0.60
DSDNA	inhibits	gene	0.60
PYROPTOSIS	inhibits	gene	0.60
DNA	associated_with	gene	0.60
CANCER	activates	gene	0.60
CGAS	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
CGAS	activates	gene	0.60
AND	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
CGAS	regulates	gene	0.60
MITOCHONDRIAL DNA	regulates	gene	0.60
AND	regulates	gene	0.60
CYTOKINES	associated_with	gene	0.60
AND	associated_with	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	0.60
AGING	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
DNA	activates	gene	0.60
GENES	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
CYTOKINES	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
PARKINSON	activates	gene	0.60
CGAS-STING	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SELF-DNA

Understanding Entity Pages

Wiki Pages (7)

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cGAS-STING Inhibitor Therapy for Neurodegeneration

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