concept

CH25H

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CH25H: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

141Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CH25H
Key Genes/Proteins	INFLAMMATION
Related Diseases	Inflammation, Alzheimer's disease, Stroke, Als, Ischemia

Wiki Pages (1)

Knowledge base pages for this entity

Disease-Associated Microglia (DAM)

mechanism · 1076 words

→

Pathway Diagram

graph TD
    CH25H["CH25H"]
    CH25H -->|"activates"| Inflammation["Inflammation"]
    CH25H -->|"activates"| Stroke["Stroke"]
    CH25H -->|"activates"| Als["Als"]
    CH25H -->|"activates"| Ischemia["Ischemia"]
    CH25H -->|"activates"| Ms["Ms"]
    CH25H -->|"activates"| Melanoma["Melanoma"]
    CH25H -->|"activates"| Infection["Infection"]
    CH25H -->|"activates"| Bacterial_Infection["Bacterial Infection"]
    INFLAMMATION["INFLAMMATION"] -->|"activates"| CH25H
    ANXA2["ANXA2"] -->|"activates"| CH25H
    ICAM1["ICAM1"] -->|"activates"| CH25H
    CD44["CD44"] -->|"activates"| CH25H
    HMOX1["HMOX1"] -->|"activates"| CH25H
    SPP1["SPP1"] -->|"activates"| CH25H
    MICROGLIA["MICROGLIA"] -->|"activates"| CH25H
    TIMP1["TIMP1"] -->|"activates"| CH25H

Outgoing (90)

Target	Relation	Type	Str
Inflammation	activates	disease	0.75
Alzheimer's disease	associated_with	disease	0.70
Stroke	activates	disease	0.65
Als	activates	disease	0.65
Ischemia	activates	disease	0.65
Ms	activates	disease	0.65
Melanoma	activates	disease	0.65
Infection	activates	disease	0.65
Bacterial Infection	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Atherosclerosis	transports	disease	0.65
Alzheimer	transports	disease	0.65
ALS	transports	disease	0.65
Atherosclerosis	degrades	disease	0.65
Alzheimer	degrades	disease	0.65
Als	degrades	disease	0.65
Tauopathy	regulates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
ATF3	activates	gene	0.60
VIM	activates	gene	0.60
DNA	inhibits	gene	0.60
Cholesterol	activates	pathway	0.60
Lipid Metabolism	activates	pathway	0.60
Inflammasome	activates	pathway	0.60
LRP8	activates	gene	0.60
APOA1	activates	gene	0.60
MAPT	regulates	gene	0.60
LRP1	activates	gene	0.60
LIPA	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
APP	regulates	gene	0.60
APOE	activates	gene	0.60
CYP46A1	activates	gene	0.60
ABCA1	activates	gene	0.60
NCSTN	regulates	gene	0.60
APOD	activates	gene	0.60
GSK3B	regulates	gene	0.60
PSEN1	regulates	gene	0.60
SREBF1	regulates	gene	0.60
APOC1	activates	gene	0.60
TFCP2	regulates	gene	0.60
APOC2	activates	gene	0.60
SOAT1	activates	gene	0.60
ABCA2	activates	gene	0.60
PSEN2	regulates	gene	0.60
TAU	regulates	gene	0.60
LDLR	activates	gene	0.60

Incoming (51)

Source	Relation	Type	Str
INFLAMMATION	activates	gene	0.70
ANXA2	activates	gene	0.60
ICAM1	activates	gene	0.60
CD44	activates	gene	0.60
HMOX1	activates	gene	0.60
SPP1	activates	gene	0.60
MICROGLIA	activates	gene	0.60
TIMP1	activates	gene	0.60
LGALS3	activates	gene	0.60
CD14	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
RGS1	activates	gene	0.60
ZFP36	activates	gene	0.60
HSPB1	activates	gene	0.60
SREBP2	activates	gene	0.60
AIM2	activates	gene	0.60
MITOCHONDRIAL DNA	inhibits	gene	0.60
APOE	transports	gene	0.60
NCSTN	transports	gene	0.60
PSEN2	transports	gene	0.60
LIPA	transports	gene	0.60
LDLR	transports	gene	0.60
TFCP2	transports	gene	0.60
ABCA1	transports	gene	0.60
GSK3B	transports	gene	0.60
LRP8	transports	gene	0.60
APOA1	transports	gene	0.60
CYP46A1	transports	gene	0.60
SOAT1	transports	gene	0.60
APP	transports	gene	0.60
MAPT	transports	gene	0.60
ABCA2	transports	gene	0.60
AND	transports	gene	0.60
ALZHEIMER'S DISEASE	transports	gene	0.60
PSEN1	transports	gene	0.60
APOD	activates	gene	0.60
SREBF1	degrades	gene	0.60
CYP46A1	activates	gene	0.60
PSEN1	degrades	gene	0.60
GSK3B	degrades	gene	0.60
LRP1	activates	gene	0.60
ALZHEIMER	degrades	gene	0.60
ALZHEIMER	regulates	gene	0.60
TAU	inhibits	gene	0.60
ABCA1	activates	gene	0.60
ABCA2	activates	gene	0.60
APOA1	activates	gene	0.60
APOC1	activates	gene	0.60
APOC2	activates	gene	0.60
APOC3	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found