concept

NADH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NADH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

412Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

NADH is a concept in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with AD, ADH, ALI. Connected to 218 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NADH
Key Genes/Proteins	EEF2, SIRT1, MITOCHONDRIA, NAD
Related Diseases	Als, Cancer, Ischemia, Metabolic Syndrome, Tumor
Related Pathways	NAD+ metabolism, Mitochondrial Function, Oxidative Stress, oxidative stress response

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NADH["NADH"]
    NADH -->|"regulates"| Ischemia["Ischemia"]
    NADH -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    NADH -->|"regulates"| Tumor["Tumor"]
    NADH -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    NADH -->|"regulates"| Cancer["Cancer"]
    NADH -->|"activates"| Aging["Aging"]
    NADH -.protects against.-> Neuroinflammation["Neuroinflammation"]
    NADH -.protects against.-> Traumatic_Brain_Injury["Traumatic Brain Injury"]
    NADH -.protects against.-> Inflammation["Inflammation"]
    NADH -.protects against.-> Alzheimer["Alzheimer"]
    EEF2["EEF2"] -->|"binds"| NADH
    METHYLENE_BLUE["METHYLENE_BLUE"] -->|"interacts"| NADH
    MTOR["MTOR"] -->|"regulates"| NADH
    MYC["MYC"] -->|"regulates"| NADH
    EGFR["EGFR"] -->|"regulates"| NADH
    MTORC1["MTORC1"] -->|"regulates"| NADH
    RPS6["RPS6"] -->|"regulates"| NADH
    CTSD["CTSD"] -->|"regulates"| NADH
    ATG["ATG"] -->|"regulates"| NADH
    NAD["NAD"] -->|"regulates"| NADH

Outgoing (245)

Target	Relation	Type	Str
Als	activates	disease	0.85
NAD+ metabolism	participates_in	pathway	0.85
Cancer	associated_with	disease	0.75
SIRT1	activates	gene	0.75
MITOCHONDRIA	activates	gene	0.70
Mitochondrial Function	activates	pathway	0.70
Oxidative Stress	activates	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
Ischemia	regulates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Tumor	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cancer	regulates	disease	0.65
Aging	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Aging	activates	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Traumatic Brain Injury	protects_against	disease	0.65
Inflammation	protects_against	disease	0.65
Alzheimer	protects_against	disease	0.65
ALS	protects_against	disease	0.65
Ischemia	protects_against	disease	0.65
Parkinson	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Stroke	protects_against	disease	0.65
Infection	activates	disease	0.65
Sepsis	activates	disease	0.65
Als	regulates	disease	0.65
Stroke	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Lung Cancer	associated_with	disease	0.65
Obesity	activates	disease	0.65
Fatty Liver	activates	disease	0.65
Diabetes	activates	disease	0.65
Anxiety	inhibits	disease	0.65
Als	inhibits	disease	0.65
Traumatic Brain Injury	implicated_in	disease	0.65
Parkinson	implicated_in	disease	0.65
Als	implicated_in	disease	0.65
Neuroinflammation	implicated_in	disease	0.65
Stroke	implicated_in	disease	0.65
Inflammation	implicated_in	disease	0.65
Alzheimer	implicated_in	disease	0.65
Neurodegeneration	implicated_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65

Incoming (167)

Source	Relation	Type	Str
IDH1	associated_with	entity	0.90
IDH2	associated_with	entity	0.90
EEF2	binds	gene	0.80
CANCER	associated_with	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
NAD	inhibits	gene	0.70
ATP	regulates	gene	0.65
ISCHEMIA	regulates	disease	0.65
NAD	causes	gene	0.65
NAD	biomarker_for	gene	0.65
METHYLENE_BLUE	interacts_with	drug	0.64
MTOR	regulates	gene	0.60
MYC	regulates	gene	0.60
EGFR	regulates	gene	0.60
MTORC1	regulates	gene	0.60
RPS6	regulates	gene	0.60
CTSD	regulates	gene	0.60
ATG	regulates	gene	0.60
NAD	regulates	gene	0.60
IDH2	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
CANCER	regulates	gene	0.60
IDH1	regulates	gene	0.60
CD38	associated_with	gene	0.60
DNA	associated_with	gene	0.60
NAD	phosphorylates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
MTDNA	activates	gene	0.60
NAD	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	protects_against	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
STROKE	protects_against	gene	0.60
MITOCHONDRIA	activates	gene	0.60
ALZHEIMER	protects_against	gene	0.60
PARKINSON'S DISEASE	protects_against	gene	0.60
PARKINSON	protects_against	gene	0.60
BRAIN INJURY	protects_against	gene	0.60
NEURODEGENERATION	protects_against	gene	0.60
MAP1LC3B	regulates	gene	0.60
RAS	regulates	gene	0.60
RAB7A	regulates	gene	0.60
PIK3C3	regulates	gene	0.60
LRP2	regulates	gene	0.60
PPARG	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
NEURODEGENERATIVE DISORDERS	protects_against	gene	0.60
NAD	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NADH

Understanding Entity Pages

Summary

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Parthanatos in Neurodegeneration

coq10-neurodegeneration

Mitochondrial Quality Control

Mitochondrial Dysfunction in Parkinson's Disease

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

oxidative-stress-comparison

Coenzyme Q10 for Neurodegeneration

Mitochondrial Dysfunction in Neurodegeneration

KARS1

ATP5F1 — ATP Synthase F1 Subunit Beta

NDUFAF3 Gene

Benfotiamine Phase 2 Alzheimer's Disease Trial (NCT06223360)

Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precursor

DNA Damage Response Impairment Pathway

metabolic-dysfunction-neurodegeneration

Mitochondria

Quinolinic Acid Neurotoxicity in Neurodegeneration

dna-damage-repair