Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LEPTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
graph TD
LEPTIN["LEPTIN"]
LEPTIN -->|"regulates"| Food_Intake["Food Intake"]
LEPTIN -->|"treats"| Paqr4_Induced_Metabolic_Defect["Paqr4-Induced Metabolic Defects"]
LEPTIN -->|"treats"| Hyperglycemia["Hyperglycemia"]
LEPTIN -->|"treats"| Hyperglycaemia["Hyperglycaemia"]
LEPTIN -->|"regulates"| Aging["Aging"]
LEPTIN -->|"regulates"| Diabetes["Diabetes"]
LEPTIN -->|"regulates"| Obesity["Obesity"]
LEPTIN -->|"interacts"| Als["Als"]
PAQR4["PAQR4"] -->|"activates"| LEPTIN
CERS2["CERS2"] -->|"regulates"| LEPTIN
AGING["AGING"] -->|"regulates"| LEPTIN
ARC["ARC"] -->|"interacts"| LEPTIN
CRH["CRH"] -->|"regulates"| LEPTIN
POMC["POMC"] -->|"regulates"| LEPTIN
NPY["NPY"] -->|"regulates"| LEPTIN
NTS["NTS"] -->|"interacts"| LEPTIN| Target | Relation | Type | Str |
|---|---|---|---|
| STAT3 | activates | protein | 0.95 |
| Food Intake | regulates | process | 0.90 |
| Dopaminergic Neurodegeneration | protects_against | process | 0.90 |
| Substantia Nigra | expressed_in | brain_region | 0.90 |
| Neuroinflammation | modulates | process | 0.85 |
| Oxidative Stress | modulates | process | 0.85 |
| ABETA | regulates | protein | 0.80 |
| Synaptic Plasticity | associated_with | process | 0.80 |
| ABETA | inhibits | protein | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CERS2 | regulates | gene | 0.60 |
| ARC | interacts_with | gene | 0.60 |
| CRH | regulates | gene | 0.60 |
| POMC | regulates | gene | 0.60 |
| NPY | regulates | gene | 0.60 |
| NTS | interacts_with | gene | 0.60 |
| VIM | activates | gene | 0.60 |
| PROGRANULIN | activates | gene | 0.60 |
| VIMENTIN | activates | gene | 0.60 |
| TGM2 | biomarker_for | gene | 0.60 |
| FGF21 | activates | gene | 0.60 |
| CX3CL1 | activates | gene | 0.60 |
| HMGB1 | biomarker_for | gene | 0.60 |
| PLAU | activates | gene | 0.60 |
| JUN | regulates | gene | 0.60 |
| ST8SIA1 | associated_with | gene | 0.60 |
| TNFRSF1B | associated_with | gene | 0.60 |
| TNF | associated_with | gene | 0.60 |
| UROCORTIN | interacts_with | gene | 0.60 |
| ANGPT1 | activates | gene | 0.60 |
| SP1 | inhibits | gene | 0.60 |
| DKK1 | inhibits | gene | 0.60 |
| STAT3 | inhibits | gene | 0.60 |
| NESTIN | inhibits | gene | 0.60 |
| BDNF | expressed_in | gene | 0.60 |
| PPAR | therapeutic_target | gene | 0.60 |
| S100B | biomarker_for | gene | 0.60 |
| GPNMB | biomarker_for | gene | 0.60 |
| APP | biomarker_for | gene | 0.60 |
| BDNF | activates | gene | 0.60 |
| FGF23 | activates | gene | 0.60 |
| CXCL10 | activates | gene | 0.60 |
| FNDC5 | activates | gene | 0.60 |
| ST8SIA1 | transports | gene | 0.60 |
| C1Q | activates | gene | 0.60 |
| CD68 | activates | gene | 0.60 |
| PAQR4 | activates | gene | 0.60 |
| AGING | regulates | gene | 0.60 |
| MITOCHONDRIA | biomarker_for | gene | 0.60 |
| PGRN | activates | gene | 0.60 |
| AMYLOID | biomarker_for | gene | 0.60 |
| IL-6 | activates | gene | 0.60 |
| GHRL | biomarker_for | gene | 0.60 |
| APOPTOSIS | biomarker_for | gene | 0.60 |
| IGF-1 | biomarker_for | gene | 0.60 |
| B4GALNT1 | regulates | gene | 0.60 |
| ANXIETY | regulates | gene | 0.60 |
| AMYLOID | inhibits | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| PTP1B | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||