gene

L1CAM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about L1CAM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

58Connections

0Hypotheses

1Analyses

40Outgoing

18Incoming

0Experiments

1Debates

Summary

L1CAM encodes a neural cell adhesion molecule essential for neuronal development, axonal guidance, myelination, and synaptic plasticity. Dysfunction contributes to L1 syndrome, Alzheimer's disease, and multiple sclerosis.

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🧬 Gene Info

Gene Symbol	L1CAM
Chromosome	Xq28
Protein Type	Immunoglobulin superfamily CAM
Function	is a neural cell adhesion molecule that plays critical roles in neuronal development, axonal guidance, myelination, and synaptic plasticity.
Primary Expression	CNS (neurons, glia), PNS, developing brain
Amino Acids	1400 aa
Pathways	MAPK, PI3K
UniProt ID	P32004
NCBI Gene ID	3909
GeneCards	L1CAM
Human Protein Atlas	L1CAM
Associated Diseases	neurodegeneration
Interactions	AGING, ALZHEIMER, ATG12, AUTOPHAGY, DEMENTIA, LC3
KG Connections	58 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: L1CAM — AlphaFold P32004 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

L1CAM (L1 Cell Adhesion Molecule)

gene · 648 words

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L1CAM Protein

protein · 1279 words

→

Pathway Diagram

graph TD
    L1CAM["L1CAM"]
    PI3K["PI3K"]
    AKT["AKT"]
    MTOR["mTOR"]
    MTOR_pathway["mTOR Pathway"]
    NEURON["Neuron Function"]
    EXOSOMES["Exosomes"]
    Parkinson["Parkinson's Disease"]
    ALS["ALS"]
    Dementia["Dementia"]
    CLUSTERIN["Clusterin"]
    P53["p53"]
    ARID1A["ARID1A"]
    Neurodegeneration["Neurodegeneration"]
    
    PI3K -->|"activates"| L1CAM
    ARID1A -->|"regulates expression"| L1CAM
    P53 -->|"modulates"| L1CAM
    CLUSTERIN -->|"regulates"| L1CAM
    
    L1CAM -->|"activates"| AKT
    L1CAM -->|"activates"| MTOR
    L1CAM -->|"promotes"| MTOR_pathway
    L1CAM -->|"regulates"| NEURON
    L1CAM -->|"associates with"| EXOSOMES
    
    L1CAM -->|"therapeutic target"| ALS
    L1CAM -->|"regulates pathology"| Parkinson
    L1CAM -->|"regulates pathology"| Dementia
    L1CAM -->|"implicated in"| Neurodegeneration
    
    style L1CAM fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style PI3K fill:#4a1a6b,stroke:#333,stroke-width:2px
    style AKT fill:#4a1a6b,stroke:#333,stroke-width:2px
    style MTOR fill:#4a1a6b,stroke:#333,stroke-width:2px
    style MTOR_pathway fill:#1b5e20,stroke:#333,stroke-width:2px
    style NEURON fill:#1b5e20,stroke:#333,stroke-width:2px
    style EXOSOMES fill:#1b5e20,stroke:#333,stroke-width:2px
    style Parkinson fill:#7d4200,stroke:#333,stroke-width:2px
    style ALS fill:#7d4200,stroke:#333,stroke-width:2px
    style Dementia fill:#7d4200,stroke:#333,stroke-width:2px
    style Neurodegeneration fill:#ef5350,stroke:#333,stroke-width:2px
    style CLUSTERIN fill:#4a1a6b,stroke:#333,stroke-width:2px
    style P53 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style ARID1A fill:#4a1a6b,stroke:#333,stroke-width:2px

Outgoing (40)

Target	Relation	Type	Str
LC3	interacts_with	protein	0.95
ATG12	interacts_with	protein	0.90
AΒ	binds	protein	0.90
Aβ Elimination	mediates	process	0.85
Autophagosome	transports	organelle	0.85
Alzheimer's Disease	protects_against	disease	0.80
neuron-derived extracellular vesicles	regulates	cell_type	0.70
Cancer	treats	disease	0.65
Als	treats	disease	0.65
Dementia	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
Parkinson	regulates	disease	0.65
Als	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Mitophagy	interacts_with	pathway	0.60
MOG	biomarker_for	gene	0.60
DEMENTIA	interacts_with	gene	0.60
AGING	interacts_with	gene	0.60
Autophagy	interacts_with	pathway	0.60
NEURON	regulates	gene	0.60
EXOSOMES	associated_with	gene	0.60
oligodendrocytes	expressed_in	cell_type	0.60
astrocytes	expressed_in	cell_type	0.60
AKT	expressed_in	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
MTOR	expressed_in	gene	0.60
Neuron	associated_with	cell_type	0.60
Astrocyte	therapeutic_target	cell_type	0.60
App	therapeutic_target	protein	0.60
LC3	associated_with	gene	0.60
DEMENTIA	regulates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
lipid metabolism	participates_in	pathway	0.60
Mtor	expressed_in	pathway	0.60
Mismatch Repair	treats	pathway	0.60
neurons	expressed_in	cell_type	0.55

Incoming (18)

Source	Relation	Type	Str
P53	treats	gene	0.60
CANCER	treats	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
ARID1A	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
POLE	treats	gene	0.60
CLUSTERIN	regulates	gene	0.60
ATG12	associated_with	gene	0.60
CD63	associated_with	gene	0.60
CD9	associated_with	gene	0.60
CD81	associated_with	gene	0.60
GLS	associated_with	gene	0.60
CD9	biomarker_for	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Extracellular vesicle biomarkers for early AD detection

neurodegeneration | 2026-04-12 | 2 hypotheses Top: 0.532

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Which EV-derived biomarkers (phospho-tau, amyloid-beta, synaptic proteins, infla

closed · Rounds: 4 · Score: 0.75 · 2026-04-12

Related Research

Hypotheses and analyses mentioning L1CAM in their description or question text

No additional research found