Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about L1CAM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
L1CAM encodes a neural cell adhesion molecule essential for neuronal development, axonal guidance, myelination, and synaptic plasticity. Dysfunction contributes to L1 syndrome, Alzheimer's disease, and multiple sclerosis.
| Gene Symbol | L1CAM |
| Chromosome | Xq28 |
| Protein Type | Immunoglobulin superfamily CAM |
| Function | is a neural cell adhesion molecule that plays critical roles in neuronal development, axonal guidance, myelination, and synaptic plasticity. |
| Primary Expression | CNS (neurons, glia), PNS, developing brain |
| Amino Acids | 1400 aa |
| Pathways | MAPK, PI3K |
| UniProt ID | P32004 |
| NCBI Gene ID | 3909 |
| GeneCards | L1CAM |
| Human Protein Atlas | L1CAM |
| Protein Class | Immunoglobulin superfamily CAM |
| Ankyrin-G | Cytoplasmic tail binding |
| Integrins (α5β1, αvβ3) | Heterophilic |
| TAG-1/Axonin-1 | Heterophilic |
| Associated Diseases | neurodegeneration |
| Interactions | DEMENTIA, AGING, LC3, ATG12, AUTOPHAGY, ALZHEIMER |
| KG Connections | 57 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
L1CAM["L1CAM"]
PI3K["PI3K"]
AKT["AKT"]
MTOR["mTOR"]
MTOR_pathway["mTOR Pathway"]
NEURON["Neuron Function"]
EXOSOMES["Exosomes"]
Parkinson["Parkinson's Disease"]
ALS["ALS"]
Dementia["Dementia"]
CLUSTERIN["Clusterin"]
P53["p53"]
ARID1A["ARID1A"]
Neurodegeneration["Neurodegeneration"]
PI3K -->|"activates"| L1CAM
ARID1A -->|"regulates expression"| L1CAM
P53 -->|"modulates"| L1CAM
CLUSTERIN -->|"regulates"| L1CAM
L1CAM -->|"activates"| AKT
L1CAM -->|"activates"| MTOR
L1CAM -->|"promotes"| MTOR_pathway
L1CAM -->|"regulates"| NEURON
L1CAM -->|"associates with"| EXOSOMES
L1CAM -->|"therapeutic target"| ALS
L1CAM -->|"regulates pathology"| Parkinson
L1CAM -->|"regulates pathology"| Dementia
L1CAM -->|"implicated in"| Neurodegeneration
style L1CAM fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
style PI3K fill:#4a1a6b,stroke:#333,stroke-width:2px
style AKT fill:#4a1a6b,stroke:#333,stroke-width:2px
style MTOR fill:#4a1a6b,stroke:#333,stroke-width:2px
style MTOR_pathway fill:#1b5e20,stroke:#333,stroke-width:2px
style NEURON fill:#1b5e20,stroke:#333,stroke-width:2px
style EXOSOMES fill:#1b5e20,stroke:#333,stroke-width:2px
style Parkinson fill:#7d4200,stroke:#333,stroke-width:2px
style ALS fill:#7d4200,stroke:#333,stroke-width:2px
style Dementia fill:#7d4200,stroke:#333,stroke-width:2px
style Neurodegeneration fill:#ef5350,stroke:#333,stroke-width:2px
style CLUSTERIN fill:#4a1a6b,stroke:#333,stroke-width:2px
style P53 fill:#4a1a6b,stroke:#333,stroke-width:2px
style ARID1A fill:#4a1a6b,stroke:#333,stroke-width:2px| Target | Relation | Type | Str |
|---|---|---|---|
| LC3 | interacts_with | protein | 0.95 |
| ATG12 | interacts_with | protein | 0.90 |
| AΒ | binds | protein | 0.90 |
| Aβ Elimination | mediates | process | 0.85 |
| Autophagosome | transports | organelle | 0.85 |
| Alzheimer's Disease | protects_against | disease | 0.80 |
| Tumor | expressed_in | disease | 0.65 |
| Cancer | treats | disease | 0.65 |
| Als | treats | disease | 0.65 |
| Parkinson | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Dementia | regulates | disease | 0.65 |
| Alzheimer | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Dementia | interacts_with | disease | 0.65 |
| Aging | interacts_with | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| AKT | expressed_in | gene | 0.60 |
| MTOR | expressed_in | gene | 0.60 |
| LC3 | associated_with | gene | 0.60 |
| MOG | biomarker_for | gene | 0.60 |
| Mtor | expressed_in | pathway | 0.60 |
| Mismatch Repair | treats | pathway | 0.60 |
| NEURON | regulates | gene | 0.60 |
| DEMENTIA | regulates | gene | 0.60 |
| EXOSOMES | associated_with | gene | 0.60 |
| DEMENTIA | interacts_with | gene | 0.60 |
| AGING | interacts_with | gene | 0.60 |
| Autophagy | interacts_with | pathway | 0.60 |
| Mitophagy | interacts_with | pathway | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| Neuron | associated_with | cell_type | 0.60 |
| Astrocyte | therapeutic_target | cell_type | 0.60 |
| App | therapeutic_target | protein | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| lipid metabolism | participates_in | pathway | 0.60 |
| oligodendrocytes | expressed_in | cell_type | 0.60 |
| astrocytes | expressed_in | cell_type | 0.60 |
| neurons | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ARID1A | expressed_in | gene | 0.60 |
| PI3K | expressed_in | gene | 0.60 |
| POLE | treats | gene | 0.60 |
| CLUSTERIN | regulates | gene | 0.60 |
| ATG12 | associated_with | gene | 0.60 |
| CD63 | associated_with | gene | 0.60 |
| CD9 | associated_with | gene | 0.60 |
| CD81 | associated_with | gene | 0.60 |
| GLS | associated_with | gene | 0.60 |
| CD9 | biomarker_for | gene | 0.60 |
| P53 | treats | gene | 0.60 |
| CANCER | treats | gene | 0.60 |
| PARKINSON'S DISEASE | regulates | gene | 0.60 |
| PARKINSON | regulates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 0.60 |
| AUTOPHAGY | interacts_with | gene | 0.60 |
| ALZHEIMER | interacts_with | gene | 0.60 |
| ASTROCYTES | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||