concept

EOMES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EOMES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

1Hypotheses

0Analyses

30Outgoing

15Incoming

0Experiments

0Debates

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💡 Concept Info

Name	EOMES
Key Genes/Proteins	ABCB1, ALDH1A1, AND, ATF3, AXIN2, B7S1
Related Diseases	Als, ALS, Cancer, Carcinoma

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Intermediate Progenitor Cells

cell · 773 words

→

Pathway Diagram

graph TD
    EOMES["EOMES"]
    EOMES -->|"activates"| Tumor["Tumor"]
    EOMES -->|"activates"| Cancer["Cancer"]
    EOMES -->|"activates"| ALS["ALS"]
    EOMES -->|"activates"| Carcinoma["Carcinoma"]
    EOMES -->|"activates"| Als["Als"]
    EOMES -->|"activates"| Immune_Response["Immune Response"]
    EOMES -->|"activates"| PD_1["PD-1"]
    EOMES -->|"activates"| PD_L1["PD-L1"]
    B7S1["B7S1"] -->|"upregulates"| EOMES
    CD8["CD8"] -->|"activates"| EOMES
    PD_L1 -->|"activates"| EOMES
    PD_1 -->|"activates"| EOMES
    AND["AND"] -->|"activates"| EOMES
    CANCER["CANCER"] -->|"activates"| EOMES

Outgoing (30)

Target	Relation	Type	Str
Als	activates	disease	0.65
ALS	activates	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
FZD7	targets	gene	0.60
IL10	targets	gene	0.60
JAG1	targets	gene	0.60
LEF1	targets	gene	0.60
MITF	targets	gene	0.60
MYC	targets	gene	0.60
NEUROD1	targets	gene	0.60
NOTCH2	targets	gene	0.60
NRCAM	targets	gene	0.60
PPARD	targets	gene	0.60
PTGS2	targets	gene	0.60
SNAI1	targets	gene	0.60
TERT	targets	gene	0.60
TNFRSF19	targets	gene	0.60
VEGFA	targets	gene	0.60
Immune Response	activates	pathway	0.60
FGF18	targets	gene	0.60
FGF20	targets	gene	0.60
PD-1	activates	gene	0.60
PD-L1	activates	gene	0.60
T Cell	activates	cell_type	0.60
CANCER	activates	gene	0.60
CD8	activates	gene	0.60
AND	activates	gene	0.60
T Cell	expressed_in	cell_type	0.55

Incoming (15)

Source	Relation	Type	Str
B7S1	upregulates	protein	0.75
CD8	activates	gene	0.60
PD-L1	activates	gene	0.60
PD-1	activates	gene	0.60
CANCER	activates	gene	0.60
ABCB1	targets	gene	0.60
ALDH1A1	targets	gene	0.60
ATF3	targets	gene	0.60
AXIN2	targets	gene	0.60
BAMBI	targets	gene	0.60
CCND1	targets	gene	0.60
CD44	targets	gene	0.60
CLDN1	targets	gene	0.60
CTLA4	targets	gene	0.60
DKK1	targets	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
C1q Binding to Specific Synaptic Proteomes via Neurexin/Neur	0.522	synaptic-biology	What determines the selectivity of compl

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (4)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Prolonged anesthesia induces neuroinflammation and complement-mediated microglia [PMID:36600274]	Xu F, Han L, Wang Y, Deng D, Ding Y, Zha	BMC Med	2023	2
Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in [PMID:37235660]	Chung HY, Wickel J, Hahn N, Mein N, Schw	Science advances	2023	0
Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and th [PMID:33628204]	Kovács, Vadászi, Bulyáki,	Frontiers in immunology	2021	0
Complement System in Neural Synapse Elimination in Development and Disease. [PMID:28826529]	["Presumey J", "Bialas A", "Carroll M"]	Advances in immunology	2017	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EOMES in their description or question text

No additional research found