concept

CTLA4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTLA4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections

0Hypotheses

0Analyses

34Outgoing

15Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CTLA4
Key Genes/Proteins	AND, CANCER, Raf, PD1, DKK1, EOMES
Related Diseases	autoimmunity, Tumor, Cancer, cancer
Related Pathways	T Cell Activation, Immune Response

Wiki Pages (4)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CTLA4["CTLA4"]
    CTLA4 -->|"regulates"| Immune_Homeostasis["Immune Homeostasis"]
    CTLA4 -->|"expressed in"| CD4__T_Cell["CD4+ T Cell"]
    CTLA4 -->|"inhibits"| T_Cell_Activation["T Cell Activation"]
    CTLA4 -->|"inhibits"| Tumor["Tumor"]
    CTLA4 -->|"inhibits"| Cancer["Cancer"]
    CTLA4 -->|"inhibits"| Immune_Response["Immune Response"]
    CTLA4 -->|"inhibits"| T_Cell["T Cell"]
    CTLA4 -->|"inhibits"| AND["AND"]
    AND -->|"inhibits"| CTLA4
    CANCER["CANCER"] -->|"inhibits"| CTLA4

Outgoing (34)

Target	Relation	Type	Str
immune homeostasis	involved_in	process	0.90
autoimmunity	risk_factor_for	disease	0.80
T Cell Activation	inhibits	biological_process	0.70
Tumor	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Immune Response	inhibits	pathway	0.60
T Cell	inhibits	cell_type	0.60
AND	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
Raf	inhibits	protein	0.60
T Cell	associated_with	cell_type	0.60
PD1	inhibits	gene	0.60
cancer	inhibits	disease	0.60
DKK1	targets	gene	0.60
EOMES	targets	gene	0.60
FGF18	targets	gene	0.60
FGF20	targets	gene	0.60
FZD7	targets	gene	0.60
IL10	targets	gene	0.60
JAG1	targets	gene	0.60
LEF1	targets	gene	0.60
MITF	targets	gene	0.60
MYC	targets	gene	0.60
NEUROD1	targets	gene	0.60
NOTCH2	targets	gene	0.60
NRCAM	targets	gene	0.60
PPARD	targets	gene	0.60
PTGS2	targets	gene	0.60
SNAI1	targets	gene	0.60
TERT	targets	gene	0.60
TNFRSF19	targets	gene	0.60
VEGFA	targets	gene	0.60
T Cell	expressed_in	cell_type	0.55
PD-L1	inhibits	gene	0.35

Incoming (15)

Source	Relation	Type	Str
AND	inhibits	gene	0.60
CD38	associated_with	gene	0.60
CD4	associated_with	gene	0.60
PD-1	associated_with	gene	0.60
AMPK	inhibits	gene	0.60
ABCB1	targets	gene	0.60
ALDH1A1	targets	gene	0.60
ATF3	targets	gene	0.60
AXIN2	targets	gene	0.60
BAMBI	targets	gene	0.60
CCND1	targets	gene	0.60
CD44	targets	gene	0.60
CLDN1	targets	gene	0.60
CANCER	associated_with	disease	0.45
CANCER	inhibits	disease	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CTLA4

Understanding Entity Pages

Wiki Pages (4)

Peripheral Immune System in Parkinson's Disease

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