FZD7

Understanding Entity Pages

This page aggregates everything SciDEX knows about FZD7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    FZD7["FZD7 (Frizzled-7 Receptor)"]
    WNT["Wnt Signaling Pathway"]
    BETACAT["beta-Catenin"]
    AXIN2["AXIN2"]
    CD44["CD44"]
    JAG1["JAG1 (Jagged1)"]
    NOTCH["Notch Signaling"]
    ALS["Amyotrophic Lateral Sclerosis"]
    MS["Multiple Sclerosis"]
    INFLAMMATION["Neuroinflammation"]
    NEUROREGENERATION["Neuroregeneration"]
    STEMCELLS["Neural Stem Cells"]
    SYNAPTIC["Synaptic Plasticity"]
    NEUROPROTECTION["Neuroprotective Mechanisms"]
    ATF3["ATF3"]
    CELLSURVIVAL["Cell Survival"]

    FZD7 -->|"activates"| WNT
    WNT -->|"stabilizes"| BETACAT
    BETACAT -->|"regulates"| AXIN2
    BETACAT -->|"promotes"| NEUROREGENERATION
    FZD7 -->|"interacts with"| JAG1
    JAG1 -->|"activates"| NOTCH
    NOTCH -->|"promotes"| STEMCELLS
    FZD7 -->|"therapeutic target"| ALS
    FZD7 -->|"therapeutic target"| MS
    FZD7 -->|"modulates"| INFLAMMATION
    WNT -->|"enhances"| SYNAPTIC
    FZD7 -->|"regulates"| CD44
    CD44 -->|"promotes"| NEUROPROTECTION
    ATF3 -->|"influences"| CELLSURVIVAL
    FZD7 -->|"targets"| ATF3
    NEUROREGENERATION -->|"counteracts"| ALS

    style FZD7 fill:#1a3a4a,stroke:#4fc3f7
    style NEUROREGENERATION fill:#1b5e20
    style NEUROPROTECTION fill:#1b5e20
    style CELLSURVIVAL fill:#1b5e20
    style SYNAPTIC fill:#1b5e20
    style ALS fill:#7d4200
    style MS fill:#7d4200
    style INFLAMMATION fill:#ef5350
    style AXIN2 fill:#4a1a6b
    style JAG1 fill:#4a1a6b
    style ATF3 fill:#4a1a6b
    style CD44 fill:#4a1a6b