Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NRCAM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NRCAM is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, implicated in, activates. Associated with Als, Cancer, Carcinoma. Connected to 95 entities in the SciDEX knowledge graph.
| Gene Symbol | NRCAM |
| Full Name | NRCAM |
| Protein Type | Gene |
| Function | is a member of the L1 family of cell adhesion molecules (L1-CAMs). |
| Primary Expression | the developing brain and continues to be expressed in adult neurons |
| Pathways | Epithelial-Mesenchymal Transition |
| NCBI Gene ID | Search NCBI |
| Ensembl ID | ENSG00000163631 |
| GeneCards | NRCAM |
| Human Protein Atlas | NRCAM |
| Associated Diseases | Cancer, Carcinoma, Hepatocellular Carcinoma, Liver Cancer |
| Interactions | MACF1 |
| KG Connections | 121 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
flowchart TD
NRCAM["NRCAM"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
NRCAM["NRCAM"] -->|"therapeutic target"| Hepatitis["Hepatitis"]
NRCAM["NRCAM"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
NRCAM["NRCAM"] -->|"therapeutic target"| Cancer["Cancer"]
NRCAM["NRCAM"] -->|"therapeutic target"| Als["Als"]
NRCAM["NRCAM"] -->|"therapeutic target"| Inflammation["Inflammation"]
NRCAM["NRCAM"] -->|"therapeutic target"| Ms["Ms"]
NRCAM["NRCAM"] -->|"therapeutic target"| NOTCH2["NOTCH2"]
NRCAM["NRCAM"] -->|"therapeutic target"| EP300["EP300"]
NRCAM["NRCAM"] -->|"therapeutic target"| CTNNB1["CTNNB1"]
NRCAM["NRCAM"] -->|"therapeutic target"| NEUROD1["NEUROD1"]
NRCAM["NRCAM"] -->|"therapeutic target"| MYC["MYC"]
style NRCAM fill:#4a1a6b,stroke:#333,color:#e0e0e0
style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
style Hepatitis fill:#ef5350,stroke:#333,color:#e0e0e0
style Carcinoma fill:#ef5350,stroke:#333,color:#e0e0e0
style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
style Als fill:#ef5350,stroke:#333,color:#e0e0e0
style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
style NOTCH2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style EP300 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style CTNNB1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style NEUROD1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style MYC fill:#4a1a6b,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Fibrosis | therapeutic_target | disease | 0.65 |
| Hepatitis | therapeutic_target | disease | 0.65 |
| Carcinoma | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Prostate Cancer | therapeutic_target | disease | 0.65 |
| Infection | therapeutic_target | disease | 0.65 |
| Hepatocellular Carcinoma | therapeutic_target | disease | 0.65 |
| Colorectal Cancer | therapeutic_target | disease | 0.65 |
| Liver Cancer | therapeutic_target | disease | 0.65 |
| Pulmonary Fibrosis | therapeutic_target | disease | 0.65 |
| Lung Cancer | therapeutic_target | disease | 0.65 |
| Pancreatic Cancer | therapeutic_target | disease | 0.65 |
| Gastric Cancer | therapeutic_target | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Hepatocellular Carcinoma | implicated_in | disease | 0.65 |
| Cancer | implicated_in | disease | 0.65 |
| Liver Cancer | implicated_in | disease | 0.65 |
| Carcinoma | implicated_in | disease | 0.65 |
| NOTCH2 | therapeutic_target | gene | 0.60 |
| EP300 | therapeutic_target | gene | 0.60 |
| CTNNB1 | therapeutic_target | gene | 0.60 |
| NEUROD1 | therapeutic_target | gene | 0.60 |
| MYC | therapeutic_target | gene | 0.60 |
| VEGFA | therapeutic_target | gene | 0.60 |
| ABCB1 | therapeutic_target | gene | 0.60 |
| FOXM1 | therapeutic_target | gene | 0.60 |
| LEF1 | therapeutic_target | gene | 0.60 |
| SMARCA4 | therapeutic_target | gene | 0.60 |
| TERT | therapeutic_target | gene | 0.60 |
| FZD7 | therapeutic_target | gene | 0.60 |
| JAG1 | therapeutic_target | gene | 0.60 |
| MITF | therapeutic_target | gene | 0.60 |
| GAIN | therapeutic_target | gene | 0.60 |
| AXIN2 | therapeutic_target | gene | 0.60 |
| CD44 | therapeutic_target | gene | 0.60 |
| ALDH1A1 | therapeutic_target | gene | 0.60 |
| FGF18 | therapeutic_target | gene | 0.60 |
| ATF3 | therapeutic_target | gene | 0.60 |
| IL10 | therapeutic_target | gene | 0.60 |
| DKK1 | therapeutic_target | gene | 0.60 |
| PPARD | therapeutic_target | gene | 0.60 |
| CLDN1 | therapeutic_target | gene | 0.60 |
| APC | therapeutic_target | gene | 0.60 |
| AXIN1 | therapeutic_target | gene | 0.60 |
| PTGS2 | therapeutic_target | gene | 0.60 |
| CREBBP | therapeutic_target | gene | 0.60 |
| FGF20 | therapeutic_target | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FGF20 | therapeutic_target | gene | 0.60 |
| BRG1 | therapeutic_target | gene | 0.60 |
| ALDH1A1 | therapeutic_target | gene | 0.60 |
| MITF | therapeutic_target | gene | 0.60 |
| LEF1 | therapeutic_target | gene | 0.60 |
| ABCB1 | therapeutic_target | gene | 0.60 |
| CLDN1 | therapeutic_target | gene | 0.60 |
| JAG1 | therapeutic_target | gene | 0.60 |
| CTNNB1 | therapeutic_target | gene | 0.60 |
| AXIN1 | therapeutic_target | gene | 0.60 |
| EP300 | therapeutic_target | gene | 0.60 |
| CD44 | therapeutic_target | gene | 0.60 |
| FGF18 | therapeutic_target | gene | 0.60 |
| SMARCA4 | therapeutic_target | gene | 0.60 |
| MYC | therapeutic_target | gene | 0.60 |
| CREBBP | therapeutic_target | gene | 0.60 |
| GAIN | therapeutic_target | gene | 0.60 |
| NEUROD1 | therapeutic_target | gene | 0.60 |
| VEGFA | therapeutic_target | gene | 0.60 |
| IL10 | therapeutic_target | gene | 0.60 |
| TERT | therapeutic_target | gene | 0.60 |
| NOTCH2 | therapeutic_target | gene | 0.60 |
| PPARD | therapeutic_target | gene | 0.60 |
| FZD7 | therapeutic_target | gene | 0.60 |
| AXIN2 | therapeutic_target | gene | 0.60 |
| MACF1 | activates | gene | 0.60 |
| MYC | causes | gene | 0.60 |
| ABCB1 | targets | gene | 0.60 |
| ALDH1A1 | targets | gene | 0.60 |
| ATF3 | targets | gene | 0.60 |
| AXIN2 | targets | gene | 0.60 |
| CD44 | targets | gene | 0.60 |
| CLDN1 | targets | gene | 0.60 |
| DKK1 | targets | gene | 0.60 |
| FGF18 | targets | gene | 0.60 |
| FGF20 | targets | gene | 0.60 |
| FZD7 | targets | gene | 0.60 |
| IL10 | targets | gene | 0.60 |
| JAG1 | targets | gene | 0.60 |
| LEF1 | targets | gene | 0.60 |
| MITF | targets | gene | 0.60 |
| MYC | targets | gene | 0.60 |
| NEUROD1 | targets | gene | 0.60 |
| NOTCH2 | targets | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| CDH1 | therapeutic_target | gene | 0.60 |
| INFLAMMATION | therapeutic_target | gene | 0.60 |
| BAMBI | therapeutic_target | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| CANCER | implicated_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||