gene

NRCAM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NRCAM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

121Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

NRCAM is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, implicated in, activates. Associated with Als, Cancer, Carcinoma. Connected to 95 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolNRCAM
Full NameNRCAM
Protein TypeGene
Functionis a member of the L1 family of cell adhesion molecules (L1-CAMs).
Primary Expressionthe developing brain and continues to be expressed in adult neurons
PathwaysEpithelial-Mesenchymal Transition
NCBI Gene IDSearch NCBI
Ensembl IDENSG00000163631
GeneCardsNRCAM
Human Protein AtlasNRCAM
Associated DiseasesCancer, Carcinoma, Hepatocellular Carcinoma, Liver Cancer
InteractionsMACF1
KG Connections121 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (16)

Knowledge base pages for this entity

Canonical Page

NRCAM Gene

gene · 501 words

HNRNPH2 Gene

gene · 2633 words

LEF1

gene · 2527 words

RNA Metabolism in Alzheimer's Disease

mechanism · 2071 words

Axon Initial Segment in Neurodegeneration

cell · 1600 words

CNTN2 — Contactin 2

gene · 1461 words

Pathway Diagram

flowchart TD
    NRCAM["NRCAM"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
    NRCAM["NRCAM"] -->|"therapeutic target"| Hepatitis["Hepatitis"]
    NRCAM["NRCAM"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    NRCAM["NRCAM"] -->|"therapeutic target"| Cancer["Cancer"]
    NRCAM["NRCAM"] -->|"therapeutic target"| Als["Als"]
    NRCAM["NRCAM"] -->|"therapeutic target"| Inflammation["Inflammation"]
    NRCAM["NRCAM"] -->|"therapeutic target"| Ms["Ms"]
    NRCAM["NRCAM"] -->|"therapeutic target"| NOTCH2["NOTCH2"]
    NRCAM["NRCAM"] -->|"therapeutic target"| EP300["EP300"]
    NRCAM["NRCAM"] -->|"therapeutic target"| CTNNB1["CTNNB1"]
    NRCAM["NRCAM"] -->|"therapeutic target"| NEUROD1["NEUROD1"]
    NRCAM["NRCAM"] -->|"therapeutic target"| MYC["MYC"]
    style NRCAM fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Hepatitis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Carcinoma fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style NOTCH2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style EP300 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style CTNNB1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style NEUROD1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style MYC fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (67)

TargetRelationTypeStr
Fibrosistherapeutic_targetdisease0.65
Hepatitistherapeutic_targetdisease0.65
Carcinomatherapeutic_targetdisease0.65
Cancertherapeutic_targetdisease0.65
Alstherapeutic_targetdisease0.65

Incoming (54)

SourceRelationTypeStr
FGF20therapeutic_targetgene0.60
BRG1therapeutic_targetgene0.60
ALDH1A1therapeutic_targetgene0.60
MITFtherapeutic_targetgene0.60
LEF1therapeutic_targetgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found