Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BAMBI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
BAMBI is a concept in neurodegeneration research. Key relationships include: therapeutic target, regulates, inhibits. Associated with Als, Cancer, Carcinoma. Connected to 98 entities in the SciDEX knowledge graph.
| Name | BAMBI |
| Key Genes/Proteins | PPARGC1A, ACSL5 |
| Related Diseases | Carcinoma, Ms, Fibrosis, Hepatitis, Cancer |
| Related Pathways | TGF-β/SMAD Signaling |
Knowledge base pages for this entity
graph TD
BAMBI["BAMBI"]
BAMBI -->|"regulates"| ACSL5["ACSL5"]
BAMBI -->|"activates"| Carcinoma["Carcinoma"]
BAMBI -->|"inhibits"| Ms["Ms"]
BAMBI -->|"target for"| Fibrosis["Fibrosis"]
BAMBI -->|"target for"| Hepatitis["Hepatitis"]
BAMBI -->|"target for"| Cancer["Cancer"]
BAMBI -->|"target for"| Als["Als"]
BAMBI -->|"target for"| Inflammation["Inflammation"]
PPARGC1A["PPARGC1A"] -->|"inhibits"| BAMBI
WTAP["WTAP"] -->|"inhibits"| BAMBI
ACSL5 -->|"regulates"| BAMBI
FGF20["FGF20"] -->|"target for"| BAMBI
BRG1["BRG1"] -->|"target for"| BAMBI
NRCAM["NRCAM"] -->|"target for"| BAMBI
NOTCH2["NOTCH2"] -->|"target for"| BAMBI
EP300["EP300"] -->|"target for"| BAMBI
CTNNB1["CTNNB1"] -->|"target for"| BAMBI
NEUROD1["NEUROD1"] -->|"target for"| BAMBI| Target | Relation | Type | Str |
|---|---|---|---|
| TGF-β/SMAD Signaling | involved_in | pathway | 0.80 |
| ACSL5 | regulates | gene | 0.72 |
| Carcinoma | activates | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Fibrosis | therapeutic_target | disease | 0.65 |
| Hepatitis | therapeutic_target | disease | 0.65 |
| Carcinoma | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Prostate Cancer | therapeutic_target | disease | 0.65 |
| Infection | therapeutic_target | disease | 0.65 |
| Hepatocellular Carcinoma | therapeutic_target | disease | 0.65 |
| Colorectal Cancer | therapeutic_target | disease | 0.65 |
| Liver Cancer | therapeutic_target | disease | 0.65 |
| Pulmonary Fibrosis | therapeutic_target | disease | 0.65 |
| Lung Cancer | therapeutic_target | disease | 0.65 |
| Pancreatic Cancer | therapeutic_target | disease | 0.65 |
| Gastric Cancer | therapeutic_target | disease | 0.65 |
| TGFB_SIGNALING | participates_in | pathway | 0.64 |
| PPARGC1A | regulates | gene | 0.60 |
| METTL3 | inhibits | gene | 0.60 |
| Wnt | inhibits | pathway | 0.60 |
| Tgf-Β | regulates | pathway | 0.60 |
| Ferroptosis | regulates | pathway | 0.60 |
| ATF3 | therapeutic_target | gene | 0.60 |
| IL10 | therapeutic_target | gene | 0.60 |
| DKK1 | therapeutic_target | gene | 0.60 |
| PPARD | therapeutic_target | gene | 0.60 |
| CLDN1 | therapeutic_target | gene | 0.60 |
| APC | therapeutic_target | gene | 0.60 |
| AXIN1 | therapeutic_target | gene | 0.60 |
| PTGS2 | therapeutic_target | gene | 0.60 |
| CREBBP | therapeutic_target | gene | 0.60 |
| Wnt | therapeutic_target | pathway | 0.60 |
| Epigenetic | therapeutic_target | pathway | 0.60 |
| Notch | therapeutic_target | pathway | 0.60 |
| METTL3 | activates | gene | 0.60 |
| WTAP | activates | gene | 0.60 |
| BRG1 | therapeutic_target | gene | 0.60 |
| CD44 | therapeutic_target | gene | 0.60 |
| FGF18 | therapeutic_target | gene | 0.60 |
| SMARCA4 | therapeutic_target | gene | 0.60 |
| MYC | therapeutic_target | gene | 0.60 |
| NRCAM | therapeutic_target | gene | 0.60 |
| TERT | therapeutic_target | gene | 0.60 |
| NOTCH2 | therapeutic_target | gene | 0.60 |
| NEUROD1 | therapeutic_target | gene | 0.60 |
| FGF20 | therapeutic_target | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PPARGC1A | represses | gene | 0.80 |
| PPARGC1A | inhibits | gene | 0.72 |
| WTAP | inhibits | gene | 0.60 |
| ACSL5 | regulates | gene | 0.60 |
| FGF20 | therapeutic_target | gene | 0.60 |
| BRG1 | therapeutic_target | gene | 0.60 |
| NRCAM | therapeutic_target | gene | 0.60 |
| NOTCH2 | therapeutic_target | gene | 0.60 |
| EP300 | therapeutic_target | gene | 0.60 |
| CTNNB1 | therapeutic_target | gene | 0.60 |
| NEUROD1 | therapeutic_target | gene | 0.60 |
| MYC | therapeutic_target | gene | 0.60 |
| VEGFA | therapeutic_target | gene | 0.60 |
| ABCB1 | therapeutic_target | gene | 0.60 |
| FOXM1 | therapeutic_target | gene | 0.60 |
| LEF1 | therapeutic_target | gene | 0.60 |
| SMARCA4 | therapeutic_target | gene | 0.60 |
| TERT | therapeutic_target | gene | 0.60 |
| CDH1 | therapeutic_target | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| FZD7 | therapeutic_target | gene | 0.60 |
| JAG1 | therapeutic_target | gene | 0.60 |
| MITF | therapeutic_target | gene | 0.60 |
| GAIN | therapeutic_target | gene | 0.60 |
| AXIN2 | therapeutic_target | gene | 0.60 |
| CD44 | therapeutic_target | gene | 0.60 |
| ALDH1A1 | therapeutic_target | gene | 0.60 |
| FGF18 | therapeutic_target | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| CLDN1 | therapeutic_target | gene | 0.60 |
| AXIN1 | therapeutic_target | gene | 0.60 |
| INFLAMMATION | therapeutic_target | gene | 0.60 |
| ROS | regulates | gene | 0.60 |
| METTL3 | inhibits | gene | 0.60 |
| PPARGC1A | regulates | gene | 0.60 |
| CREBBP | therapeutic_target | gene | 0.60 |
| IL10 | therapeutic_target | gene | 0.60 |
| PPARD | therapeutic_target | gene | 0.60 |
| APC | therapeutic_target | gene | 0.60 |
| DKK1 | therapeutic_target | gene | 0.60 |
| WNT | inhibits | gene | 0.60 |
| FERROPTOSIS | regulates | gene | 0.60 |
| ACSL5 | associated_with | gene | 0.60 |
| ABCB1 | targets | gene | 0.60 |
| ALDH1A1 | targets | gene | 0.60 |
| ATF3 | targets | gene | 0.60 |
| AXIN2 | targets | gene | 0.60 |
| PPARGC1A | activates | gene | 0.50 |
| CARCINOMA | activates | disease | 0.50 |
| SMAD | regulates | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||