gene

FGF18

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF18: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

123Connections

0Hypotheses

0Analyses

50Outgoing

42Incoming

Summary

FGF18 (Fibroblast Growth Factor 18) - a growth factor implicated in neurogenesis, synaptic plasticity, and therapeutic potential in Alzheimer's disease and Parkinson's disease

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🧬 Gene Info

Gene Symbol	FGF18
Full Name	Fibroblast Growth Factor 18
Chromosome	5q33.1
Function	is a member of the fibroblast growth factor (FGF) family that plays important roles in development, tissue repair, and nervous system function.
Primary Expression	various tissues during development, with highest expression in bone, lung, and brain
Amino Acids	207 aa
Pathways	MAPK
UniProt ID	[O76093](https://www.uniprot.org/uniprot/O76093)
Ensembl ID	ENSG00000156427
GeneCards	FGF18
Human Protein Atlas	FGF18
MAPK/ERK pathway	Regulates cell proliferation and differentiation
PI3K/Akt pathway	Promotes cell survival
PLCγ pathway	Modulates calcium signaling
Subventricular zone	Maintains neural stem cell pools
Associated Diseases	neurodegeneration
Interactions	UBIQUITIN, KEAP1, NRF2
KG Connections	123 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (16)

Knowledge base pages for this entity

Canonical Page

Adult Hippocampal Neurogenesis: Impaired in Alzheimer's Disease, Enhanced in Superagers

mechanism · 2362 words

→

Fibroblast Growth Factor Signaling in Neurodegeneration

mechanism · 1987 words

→

Pathway Diagram

graph TD
    FGF18["FGF18"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
    FGF18["FGF18"] -->|"therapeutic target"| Hepatitis["Hepatitis"]
    FGF18["FGF18"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    FGF18["FGF18"] -->|"therapeutic target"| Cancer["Cancer"]
    FGF18["FGF18"] -->|"therapeutic target"| Als["Als"]
    FGF18["FGF18"] -->|"therapeutic target"| Inflammation["Inflammation"]
    FGF20["FGF20"] -->|"therapeutic target"| FGF18["FGF18"]
    BRG1["BRG1"] -->|"therapeutic target"| FGF18["FGF18"]
    NRCAM["NRCAM"] -->|"therapeutic target"| FGF18["FGF18"]
    NOTCH2["NOTCH2"] -->|"therapeutic target"| FGF18["FGF18"]
    style FGF18 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (81)

Target	Relation	Type	Str
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Ischemia	regulates	disease	0.65
Ms	activates	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
ATF3	therapeutic_target	gene	0.60
IL10	therapeutic_target	gene	0.60
DKK1	therapeutic_target	gene	0.60
PPARD	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
APC	therapeutic_target	gene	0.60
AXIN1	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
CREBBP	therapeutic_target	gene	0.60
UBIQUITIN	activates	gene	0.60
BECLIN1	expressed_in	gene	0.60
BECN1	expressed_in	gene	0.60
ATG3	expressed_in	gene	0.60
ATG7	expressed_in	gene	0.60
PIK3C3	expressed_in	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
NRCAM	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
FGF20	therapeutic_target	gene	0.60
AXIN2	therapeutic_target	gene	0.60
FOXM1	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
FZD7	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
BRG1	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60

Incoming (42)

Source	Relation	Type	Str
FGF20	therapeutic_target	gene	0.60
BRG1	therapeutic_target	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
FOXM1	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
FZD7	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
AXIN2	therapeutic_target	gene	0.60
CD44	therapeutic_target	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
KEAP1	activates	gene	0.60
NRF2	activates	gene	0.60
CLDN1	therapeutic_target	gene	0.60
AXIN1	therapeutic_target	gene	0.60
CREBBP	therapeutic_target	gene	0.60
ABCB1	targets	gene	0.60
ALDH1A1	targets	gene	0.60
ATF3	targets	gene	0.60
AXIN2	targets	gene	0.60
CD44	targets	gene	0.60
CLDN1	targets	gene	0.60
DKK1	targets	gene	0.60
CDH1	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
BAMBI	therapeutic_target	gene	0.60
BAMBI	targets	gene	0.60
CCND1	targets	gene	0.60
CTLA4	targets	gene	0.60
EOMES	targets	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FGF18

Understanding Entity Pages

Summary

Wiki Pages (16)

FGF18 Gene

FGF10 — Fibroblast Growth Factor 10

FGF Signaling Pathway in Neurodegeneration

FGF Signaling in Parkinson's Disease

Adult Hippocampal Neurogenesis: Impaired in Alzheimer's Disease, Enhanced in Superagers

Fibroblast Growth Factor Signaling in Neurodegeneration

fgf-fgfr-modulator-therapy

FGF-2 Protein (bFGF)

AD FGF/FGFR Signaling Companies

Growth Factor Signaling in 4R-Tauopathies

FGFR3 - Fibroblast Growth Factor Receptor 3

Growth Factor Therapies

FGF17 Gene

Intermediate Progenitor Cells