Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about METASTASIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | METASTASIS |
| Key Genes/Proteins | PGC1A, MMP9, HDAC3, PI3K, AKT |
| Related Diseases | CANCER, EMT |
| Related Pathways | PI3K/AKT PATHWAY |
Knowledge base pages for this entity
graph TD
METASTASIS["METASTASIS"] -->|"activates"| CANCER["CANCER"]
style CANCER fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
METASTASIS["METASTASIS"] -->|"activates"| HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"]
style HEPATOCELLULAR_CARCINOMA fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
METASTASIS["METASTASIS"] -->|"activates"| STAT3["STAT3"]
style STAT3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
METASTASIS["METASTASIS"] -->|"regulates"| BREAST_CANCER["BREAST CANCER"]
style BREAST_CANCER fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
METASTASIS["METASTASIS"] -->|"activates"| MTOR["MTOR"]
style MTOR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
METASTASIS["METASTASIS"] -->|"activates"| AKT["AKT"]
style AKT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
METASTASIS["METASTASIS"] -->|"activates"| CARCINOMA["CARCINOMA"]
style CARCINOMA fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
EMT["EMT"] -->|"activates"| METASTASIS["METASTASIS"]
style EMT fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
PGC1A["PGC1A"] -->|"activates"| METASTASIS["METASTASIS"]
style PGC1A fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
TRF33["TRF33"] -.->|"inhibits"| METASTASIS["METASTASIS"]
style TRF33 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
HEPATOCELLULAR_CARCINOMA_1["HEPATOCELLULAR CARCINOMA"] -->|"associated"| METASTASIS["METASTASIS"]
style HEPATOCELLULAR_CARCINOMA_1 fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
EXOSOMES["EXOSOMES"] -->|"causes"| METASTASIS["METASTASIS"]
style EXOSOMES fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style METASTASIS fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| CANCER | activates | disease | 0.86 |
| CANCER | associated_with | disease | 0.72 |
| CANCER | inhibits | disease | 0.72 |
| AKT | mediated_by | gene | 0.65 |
| EXOSOME | activates | organelle | 0.65 |
| MMP9 | regulates | gene | 0.65 |
| HDAC3 | regulates | gene | 0.65 |
| PI3K/AKT PATHWAY | regulates | pathway | 0.65 |
| PI3K/AKT PATHWAY | interacts_with | pathway | 0.65 |
| PI3K/AKT PATHWAY | activates | pathway | 0.65 |
| PI3K | interacts_with | gene | 0.65 |
| CANCER | regulates | disease | 0.58 |
| DRUG RESISTANCE | implicated_in | phenotype | 0.55 |
| GLIOMA | expressed_in | disease | 0.55 |
| ASPIRIN | associated_with | drug | 0.45 |
| EXOSOME | associated_with | organelle | 0.45 |
| LUTEOLIN | associated_with | drug | 0.45 |
| HEPATOCELLULAR CARCINOMA | activates | disease | 0.44 |
| HEPATOCELLULAR CARCINOMA | inhibits | disease | 0.44 |
| CANCER | causes | disease | 0.44 |
| STAT3 | activates | gene | 0.44 |
| BREAST CANCER | regulates | disease | 0.44 |
| MTOR | activates | gene | 0.44 |
| AKT | activates | gene | 0.44 |
| NECROPTOSIS | co_discussed | process | 0.40 |
| OBESITY | co_discussed | disease | 0.40 |
| NEUROGENESIS | co_discussed | process | 0.40 |
| MTOR | co_discussed | gene | 0.40 |
| PI3K | co_discussed | gene | 0.40 |
| VEGF | co_discussed | gene | 0.40 |
| UBIQUITIN | co_discussed | protein | 0.40 |
| OXIDATIVE STRESS | co_discussed | process | 0.40 |
| MTOR SIGNALING | inhibits | process | 0.35 |
| NECROPTOSIS | regulates | process | 0.35 |
| NEUROGENESIS | activates | process | 0.35 |
| MTOR SIGNALING | activates | process | 0.35 |
| OBESITY | activates | disease | 0.35 |
| PI3K/AKT SIGNALING | regulates | process | 0.35 |
| VEGF | implicated_in | gene | 0.35 |
| PI3K/AKT SIGNALING | inhibits | process | 0.35 |
| NAFLD | metabolizes | disease | 0.35 |
| NAFLD | activates | disease | 0.35 |
| NAFLD | expressed_in | disease | 0.35 |
| MICRORNA REGULATION | activates | process | 0.35 |
| ORGANOIDS | expressed_in | cell_type | 0.35 |
| MICRORNA REGULATION | regulates | process | 0.35 |
| SLC7A11 | implicated_in | gene | 0.35 |
| SLC7A11 | inhibits | gene | 0.35 |
| CARCINOMA | activates | disease | 0.30 |
| FERROPTOSIS | inhibits | process | 0.30 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CANCER | activates | gene | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| PI3K | regulates | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| AKT | regulates | gene | 1.00 |
| MTOR | regulates | gene | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
| Tumor | regulates | disease | 1.00 |
| STAT3 | activates | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| Tumor | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| CANCER | implicated_in | gene | 1.00 |
| Cancer | implicated_in | disease | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| GENES | inhibits | gene | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Colorectal Cancer | activates | disease | 1.00 |
| OVERVIEW | therapeutic_target | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| Tumor | causes | disease | 1.00 |
| MICRORNAS | therapeutic_target | gene | 1.00 |
| Lung Cancer | therapeutic_target | disease | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| MTOR | therapeutic_target | gene | 1.00 |
| Breast Cancer | therapeutic_target | disease | 1.00 |
| Tumor | associated_with | disease | 1.00 |
| APOPTOSIS | inhibits | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| MTOR | activates | gene | 1.00 |
| CANCER | causes | gene | 1.00 |
| Cancer | causes | disease | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||