HDAC11

Understanding Entity Pages

This page aggregates everything SciDEX knows about HDAC11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Histone Deacetylase 11 - the sole class IV HDAC with roles in immune regulation, metabolism, and neuroinflammation

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graph TD
    HDAC11["<b>HDAC11</b>"]
    Neurodegeneration{"Neurodegeneration"}
    HDAC11 -->|"regulates"| Neurodegeneration
    Parkinson{"Parkinson"}
    HDAC11 -->|"regulates"| Parkinson
    Alzheimer{"Alzheimer"}
    HDAC11 -->|"regulates"| Alzheimer
    Neuroinflammation{"Neuroinflammation"}
    HDAC11 -->|"regulates"| Neuroinflammation
    Inflammation{"Inflammation"}
    HDAC11 -->|"regulates"| Inflammation
    Huntington{"Huntington"}
    HDAC11 -->|"regulates"| Huntington
    Ms{"Ms"}
    HDAC11 -->|"regulates"| Ms
    HDAC2["HDAC2"]
    HDAC11 -->|"expressed in"| HDAC2
    SIRT7["SIRT7"]
    HDAC11 -->|"regulates"| SIRT7
    SIRT5["SIRT5"]
    HDAC11 -->|"regulates"| SIRT5
    BDNF["BDNF"]
    HDAC11 -->|"regulates"| BDNF
    SIRT1["SIRT1"]
    HDAC11 -->|"regulates"| SIRT1
    SIRT6["SIRT6"]
    SIRT6 -->|"regulates"| HDAC11
    BDNF -->|"regulates"| HDAC11
    HDAC3["HDAC3"]
    HDAC3 -->|"expressed in"| HDAC11
    style HDAC11 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0