SIRT4

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIRT4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

SIRT4 is a protein involved in neurodegeneration research. Key relationships include: regulates, expressed in, implicated in. Associated with Als, Alzheimer, Autoimmune. Connected to 59 entities in the SciDEX knowledge graph.

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graph TD
    SIRT4["<b>SIRT4</b>"]
    Neurodegeneration{"Neurodegeneration"}
    SIRT4 -->|"regulates"| Neurodegeneration
    Parkinson{"Parkinson"}
    SIRT4 -->|"regulates"| Parkinson
    Alzheimer{"Alzheimer"}
    SIRT4 -->|"regulates"| Alzheimer
    Neuroinflammation{"Neuroinflammation"}
    SIRT4 -->|"regulates"| Neuroinflammation
    Inflammation{"Inflammation"}
    SIRT4 -->|"regulates"| Inflammation
    Huntington{"Huntington"}
    SIRT4 -->|"regulates"| Huntington
    Ms{"Ms"}
    SIRT4 -->|"regulates"| Ms
    Als{"Als"}
    SIRT4 -->|"expressed in"| Als
    HDAC7["HDAC7"]
    SIRT4 -->|"regulates"| HDAC7
    Oxidative_Stress(["Oxidative Stress"])
    SIRT4 -->|"regulates"| Oxidative_Stress
    SIRT7["SIRT7"]
    SIRT4 -->|"expressed in"| SIRT7
    HDAC6["HDAC6"]
    SIRT4 -->|"regulates"| HDAC6
    SIRT6["SIRT6"]
    SIRT6 -->|"expressed in"| SIRT4
    HDAC11["HDAC11"]
    HDAC11 -->|"regulates"| SIRT4
    HDAC2["HDAC2"]
    HDAC2 -->|"regulates"| SIRT4
    SIRT7 -->|"expressed in"| SIRT4
    SIRT5["SIRT5"]
    SIRT5 -->|"expressed in"| SIRT4
    BDNF["BDNF"]
    BDNF -->|"regulates"| SIRT4
    SIRT1["SIRT1"]
    SIRT1 -->|"expressed in"| SIRT4
    HDAC1["HDAC1"]
    HDAC1 -->|"regulates"| SIRT4
    SIRT2["SIRT2"]
    SIRT2 -->|"expressed in"| SIRT4
    SIRT3["SIRT3"]
    SIRT3 -->|"expressed in"| SIRT4
    HDAC3["HDAC3"]
    HDAC3 -->|"regulates"| SIRT4
    HDAC6 -->|"regulates"| SIRT4
    style SIRT4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0