gene

SIRT5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIRT5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

219Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

SIRT5 - Sirtuin 5, mitochondrial sirtuin with desuccinylation, demalonylation, and deglutarylation activities

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🧬 Gene Info

Gene Symbol	SIRT5
Full Name	Sirtuin 5
Aliases	Page for SIRT5 Protein
Chromosome	6p23
Protein Family	Sirtuin family (class I)
Function	is a member of the sirtuin family of NAD⁺-dependent protein deacylases that is primarily localized to mitochondria.
Subcellular Localization	mitochondria. Unlike other sirtuins, SIRT5 possesses unique enzymatic activities including desuccinylation, demalonylati
Molecular Weight	34 kDa
Amino Acids	310 aa
Pathways	Glutamine Metabolism, Glycolysis, Mitophagy, Oxidative Stress, Unfolded Protein Response
UniProt ID	Q9NXE1
NCBI Gene ID	83737
Ensembl ID	ENSG00000124587
OMIM	604603
GeneCards	SIRT5
Human Protein Atlas	SIRT5
Associated Diseases	ALS, Alzheimer, cancer
Known Drugs/Compounds	Mc3482, MC3482
Interactions	BNIP3, PINK1, PARK2, MAP1LC3B, GABARAPL2, EP300
KG Connections	219 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SIRT5 — AlphaFold Q9NXE1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SIRT5["SIRT5"]
    SIRT5 -->|"contributes to"| Cancer["Cancer"]
    SIRT5 -->|"activates"| Als["Als"]
    SIRT5 -->|"regulates"| Inflammation["Inflammation"]
    SIRT5 -->|"regulates"| Cardiac["Cardiac"]
    SIRT5 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    SIRT5 -->|"regulates"| Parkinson["Parkinson"]
    SIRT5 -->|"regulates"| Alzheimer["Alzheimer"]
    SIRT5 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    SIRT5 -->|"regulates"| Huntington["Huntington"]
    SIRT5 -->|"regulates"| Ms["Ms"]
    GABARAP["GABARAP"] -->|"activates"| SIRT5
    GABARAPL2["GABARAPL2"] -->|"activates"| SIRT5
    BNIP3["BNIP3"] -->|"activates"| SIRT5
    SIRT6["SIRT6"] -->|"expressed in"| SIRT5
    HDAC11["HDAC11"] -->|"regulates"| SIRT5
    HDAC2["HDAC2"] -->|"regulates"| SIRT5
    SIRT7["SIRT7"] -->|"expressed in"| SIRT5

Outgoing (141)

Target	Relation	Type	Str
CPS1	regulates	enzyme	0.95
Ammonia Detoxification	regulates	process	0.95
Ammonia Production	regulates	process	0.90
Glutamine Metabolism	regulates	pathway	0.90
RAB7A	mediates	protein	0.90
Autophagic Flux	regulates	process	0.90
Glutaminase	interacts_with	enzyme	0.90
Glutaminase	modulates	enzyme	0.90
Autophagy	regulates	process	0.90
GLUTAMINASE	interacts_with	enzyme	0.85
GLS	modulates	gene	0.85
autophagy	inhibits	process	0.85
Autophagy	modulates	process	0.85
Mitophagy	modulates	process	0.85
mitophagy	inhibits	process	0.85
LC3	regulates	entity	0.80
PINK1	regulates	entity	0.80
RAB7A	associated_with	protein	0.80
Als	activates	disease	0.75
Inflammation	regulates	disease	0.75
Senescence	activates	disease	0.75
AUTOPHAGY	activates	gene	0.70
autophagy pathway	participates_in	pathway	0.70
Cancer	contributes_to	disease	0.65
Cardiac	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Huntington	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	expressed_in	disease	0.65
Aging	activates	disease	0.65
Als	associated_with	disease	0.65
Ischemia	inhibits	disease	0.65
Ms	expressed_in	disease	0.65
ALS	activates	disease	0.65
Aging	regulates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Breast Cancer	contributes_to	disease	0.65
Autoimmune	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Cancer	inhibits	disease	0.65
Als	inhibits	disease	0.65
BNIP3	activates	gene	0.60
PINK1	activates	gene	0.60
PARK2	activates	gene	0.60
MAP1LC3B	activates	gene	0.60

Incoming (78)

Source	Relation	Type	Str
Mc3482	inhibits	drug	0.90
MC3482	inhibits	drug	0.85
SIRT4	expressed_in	gene	0.80
SIRT3	expressed_in	gene	0.80
SIRT2	expressed_in	gene	0.80
SIRT1	expressed_in	gene	0.80
SIRT6	expressed_in	gene	0.70
SIRT7	expressed_in	gene	0.70
OXIDATIVE STRESS	regulates	gene	0.70
GABARAP	activates	gene	0.60
GABARAPL2	activates	gene	0.60
BNIP3	activates	gene	0.60
HDAC11	regulates	gene	0.60
HDAC2	regulates	gene	0.60
BNIP3	regulates	gene	0.60
GABARAP	regulates	gene	0.60
GABARAPL2	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
PARK2	regulates	gene	0.60
BDNF	regulates	gene	0.60
HDAC3	regulates	gene	0.60
CFH	activates	gene	0.60
AKT2	therapeutic_target	gene	0.60
TFE3	activates	gene	0.60
MLKL	associated_with	gene	0.60
MAP1LC3B	activates	gene	0.60
PARK2	activates	gene	0.60
PINK1	activates	gene	0.60
TAU	regulates	gene	0.60
HDAC6	regulates	gene	0.60
HDAC1	regulates	gene	0.60
HDAC7	regulates	gene	0.60
APP	activates	gene	0.60
RAB7A	inhibits	gene	0.60
SIRT1	activates	gene	0.60
IRF3	inhibits	gene	0.60
AKT2	inhibits	gene	0.60
AKT2	associated_with	gene	0.60
AKT2	activates	gene	0.60
AKT2	targets	gene	0.60
AGING	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
MITOPHAGY	regulates	gene	0.60
MITOPHAGY	activates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
CANCER	contributes_to	gene	0.60
ROS	activates	gene	0.60
CYTOKINES	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SIRT5

Understanding Entity Pages

Summary

Wiki Pages (21)

SIRT5 - Sirtuin 5

autophagy-lysosomal-alzheimers

Mitochondria in Neurodegeneration

Sirtuin Signaling in Parkinson's Disease

Section 103: Sirtuin Pathway and NAD+-Dependent Deacetylases in CBS/PSP

Nicotinamide Riboside

NAD+ Metabolism in Neurodegeneration

Energy Metabolism in Neurodegeneration

Sirtuin Signaling Pathway

Mitochondrial DNA Mutations in Neurodegeneration

Geroprotective Therapies for Neurodegeneration

Sirtuin Pathway Dysfunction Hypothesis in Parkinson's Disease

Section 186: Bioenergetics and Mitochondrial Coupling Therapy in CBS/PSP

Sirtuin Signaling in Neurodegeneration

Metabolic-Epigenetic Axis in Neurodegeneration Synthesis

SIRT7 Gene

nadapt-study-nad-replenishment-parkinsonism-nct06162013

HDAC11 Gene

SIRT2 Gene