Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NOX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NOX is a concept in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Als, Cancer. Connected to 120 entities in the SciDEX knowledge graph.
| Name | NOX |
| Key Genes/Proteins | ROS |
| Related Diseases | Als, Inflammation, Lymphoma, Ms, Cancer |
| Related Pathways | Autophagy, Immune Response, oxidative stress response |
Knowledge base pages for this entity
graph TD
NOX["NOX"]
NOX -->|"activates"| Als["Als"]
NOX -->|"activates"| Ms["Ms"]
NOX -->|"activates"| Cancer["Cancer"]
NOX -->|"activates"| Cardiac["Cardiac"]
NOX -->|"activates"| Inflammation["Inflammation"]
NOX -->|"activates"| ALS["ALS"]
NOX -->|"produces"| ROS["ROS"]
NOX -->|"activates"| POR["POR"]
NOX -->|"regulates"| Ferroptosis["Ferroptosis"]
LPCAT3["LPCAT3"] -->|"activates"| NOX
ACSL4["ACSL4"] -->|"activates"| NOX
G6PD["G6PD"] -->|"activates"| NOX
SMAD3["SMAD3"] -->|"regulates"| NOX
CDH1["CDH1"] -->|"activates"| NOX
LC3B["LC3B"] -->|"activates"| NOX
NOX4["NOX4"] -->|"activates"| NOX
P62["P62"] -->|"activates"| NOX| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.75 |
| Autophagy | activates | pathway | 0.70 |
| Immune Response | activates | pathway | 0.70 |
| oxidative stress response | participates_in | pathway | 0.70 |
| ROS | activates | gene | 0.70 |
| Inflammation | associated_with | disease | 0.65 |
| Lymphoma | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Cardiac | activates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Infection | activates | disease | 0.65 |
| Obesity | activates | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Prostate Cancer | inhibits | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Autoimmune | activates | disease | 0.65 |
| Ataxia | associated_with | disease | 0.65 |
| ROS | produces | phenotype | 0.64 |
| TRAF6 | associated_with | gene | 0.60 |
| FIS1 | associated_with | gene | 0.60 |
| BAX | associated_with | gene | 0.60 |
| BCL-2 | associated_with | gene | 0.60 |
| PUMA | associated_with | gene | 0.60 |
| P53 | associated_with | gene | 0.60 |
| SIGMAR1 | associated_with | gene | 0.60 |
| CHOP | associated_with | gene | 0.60 |
| VEGF | associated_with | gene | 0.60 |
| BECLIN1 | associated_with | gene | 0.60 |
| HO-1 | associated_with | gene | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Akt | associated_with | pathway | 0.60 |
| Oxidative Stress | associated_with | pathway | 0.60 |
| Pi3K | associated_with | pathway | 0.60 |
| Apoptosis | associated_with | pathway | 0.60 |
| Toll-Like Receptor | associated_with | pathway | 0.60 |
| Blood-Brain Barrier | associated_with | pathway | 0.60 |
| Mtor | associated_with | pathway | 0.60 |
| POR | activates | gene | 0.60 |
| Ferroptosis | regulates | pathway | 0.60 |
| KEAP1 | associated_with | gene | 0.60 |
| NRF2 | associated_with | gene | 0.60 |
| SIRT1 | associated_with | gene | 0.60 |
| Blood-Brain Barrier | activates | pathway | 0.60 |
| POR | regulates | gene | 0.60 |
| Er Stress | activates | pathway | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PI3K | associated_with | gene | 0.60 |
| MYD88 | associated_with | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| NRF2 | associated_with | gene | 0.60 |
| AKT | associated_with | gene | 0.60 |
| BCL2 | associated_with | gene | 0.60 |
| TAAR1 | associated_with | gene | 0.60 |
| LPCAT3 | activates | gene | 0.60 |
| ACSL4 | activates | gene | 0.60 |
| G6PD | activates | gene | 0.60 |
| SMAD3 | regulates | gene | 0.60 |
| CDH1 | activates | gene | 0.60 |
| ACSL4 | regulates | gene | 0.60 |
| LPCAT3 | regulates | gene | 0.60 |
| LC3B | activates | gene | 0.60 |
| NOX4 | activates | gene | 0.60 |
| P62 | activates | gene | 0.60 |
| ATF6 | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| ASTROCYTES | activates | gene | 0.60 |
| BAX | associated_with | gene | 0.60 |
| BECLIN1 | associated_with | gene | 0.60 |
| PUMA | associated_with | gene | 0.60 |
| ROS | regulates | gene | 0.60 |
| POR | activates | gene | 0.60 |
| FIS1 | associated_with | gene | 0.60 |
| VEGF | associated_with | gene | 0.60 |
| APOPTOSIS | associated_with | gene | 0.60 |
| SIGMAR1 | associated_with | gene | 0.60 |
| CREB | associated_with | gene | 0.60 |
| OXIDATIVE STRESS | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| TLR | associated_with | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| CHOP | associated_with | gene | 0.60 |
| HO-1 | associated_with | gene | 0.60 |
| BCL-2 | associated_with | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| ROS | associated_with | gene | 0.60 |
| NF-KB | activates | gene | 0.60 |
| ROS | activates | gene | 0.60 |
| SIRT1 | activates | gene | 0.60 |
| MTORC1 | activates | gene | 0.60 |
| MICRORNAS | activates | gene | 0.60 |
| ROS | inhibits | gene | 0.60 |
| OXIDATIVE STRESS | activates | gene | 0.60 |
| NOX2 | inhibits | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||