gene

SPHK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPHK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

211Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

5Debates

Summary

SPHK1 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in, expressed in. Associated with ALS, Als, Amyotrophic Lateral Sclerosis. Connected to 124 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SPHK1
Full Name	Sphingosine Kinase 1
Chromosome	17q25.1
Protein Type	Kinase
Function	### Sphingolipid Rheostat
Primary Expression	Hippocampus, Cortex, Cerebellum, White matter (widespread)
Molecular Weight	42.5 kDa
Exons	6
Pathways	NF-κB
UniProt ID	Q9NYA1
NCBI Gene ID	8877
Ensembl ID	ENSG00000176884
OMIM	603730
GeneCards	SPHK1
Human Protein Atlas	SPHK1
Associated Diseases	Als, Atherosclerosis, Cardiac, Cardiovascular, Fibrosis, Heart Failure
Known Drugs/Compounds	rapamycin
Interactions	Actin, ALS, ALS-CAUSING MUTATIONS, ASTROCYTE, ASTROCYTES, ATG
SciDEX Hypotheses	Ceramide-Sphingosine-1-Phosphate Axis Rebalancing
KG Connections	211 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SPHK1 — AlphaFold Q9NYA1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SPHK1 — Sphingosine Kinase 1

gene · 1441 words

→

SPHK1 Protein

protein · 569 words

→

Pathway Diagram

graph TD
    SPHK1["SPHK1"]
    SPHK1 -->|"participates in"| Cardiovascular["Cardiovascular"]
    SPHK1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    SPHK1 -->|"activates"| Ms["Ms"]
    SPHK1 -->|"activates"| Dementia["Dementia"]
    SPHK1 -->|"activates"| Als["Als"]
    SPHK1 -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    SPHK1 -->|"activates"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    SPHK1 -->|"activates"| Ftd["Ftd"]
    SPHK1 -->|"activates"| Leukemia["Leukemia"]
    PTEN["PTEN"] -->|"activates"| SPHK1
    MAP1LC3["MAP1LC3"] -->|"activates"| SPHK1
    ALS_CAUSING_MUTATIONS["ALS-CAUSING MUTATIONS"] -->|"activates"| SPHK1
    ATG["ATG"] -->|"activates"| SPHK1
    TFEB["TFEB"] -->|"activates"| SPHK1
    GENES["GENES"] -->|"activates"| SPHK1
    DNA["DNA"] -->|"activates"| SPHK1
    VCP["VCP"] -->|"activates"| SPHK1
    ICAM1["ICAM1"] -->|"activates"| SPHK1

Outgoing (141)

Target	Relation	Type	Str
sphingosine_kinase_activity	activates	pathway	0.90
Inflammation	activates	disease	0.75
sphingolipid_metabolism	modulates	biological_process	0.70
sphingolipid_metabolism	regulates	pathway	0.70
Cardiac	implicated_in	disease	0.65
Heart Failure	implicated_in	disease	0.65
Atherosclerosis	implicated_in	disease	0.65
Heart Failure	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Hypertension	implicated_in	disease	0.65
Myocardial Infarction	implicated_in	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Leukemia	activates	disease	0.65
Ms	activates	disease	0.65
Fibrosis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Colorectal Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Dementia	activates	disease	0.65
Cardiovascular	associated_with	disease	0.65
Cardiac	regulates	disease	0.65
Hypertension	regulates	disease	0.65
Ischemia	activates	disease	0.65
Stroke	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
ALS	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Frontotemporal Dementia	activates	disease	0.65
Ftd	activates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
ASTROCYTES	activates	gene	0.60
NF-ΚB	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
Nf-Κb	activates	pathway	0.60
MAP1LC3	activates	gene	0.60
GENES	activates	gene	0.60
DEMENTIA	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Rb	activates	protein	0.60
PKC	regulates	gene	0.60
GSS	expressed_in	gene	0.60
TLR4	activates	gene	0.60
GFAP	expressed_in	gene	0.60
BDNF	expressed_in	gene	0.60
NRF2	expressed_in	gene	0.60
CD8	associated_with	gene	0.60

Incoming (70)

Source	Relation	Type	Str
PTEN	activates	gene	0.60
TFEB	activates	gene	0.60
VCP	activates	gene	0.60
CHMP2B	activates	gene	0.60
MTOR	activates	gene	0.60
LC3	activates	gene	0.60
OVERVIEW	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
VALOSIN	activates	gene	0.60
TBK1	activates	gene	0.60
PINK1	activates	gene	0.60
TARDBP	activates	gene	0.60
TLR4	activates	gene	0.60
GSS	expressed_in	gene	0.60
BDNF	expressed_in	gene	0.60
NRF2	expressed_in	gene	0.60
GFAP	expressed_in	gene	0.60
ALS-CAUSING MUTATIONS	therapeutic_target	gene	0.60
NEURON	activates	gene	0.60
NF-ΚB	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
STROKE	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
ICAM1	activates	gene	0.60
STAT3	activates	gene	0.60
STAT3	implicated_in	gene	0.60
AKT	implicated_in	gene	0.60
NLRP3	activates	gene	0.60
rapamycin	targets	drug	0.60
CAV1	regulates	gene	0.60
DEMENTIA	activates	gene	0.60
IL-6	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
CANCER	activates	gene	0.60
APOPTOSIS	implicated_in	gene	0.60
FTD	activates	entity	0.60
GENES	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
GBA	regulates	gene	0.60
MAP1LC3	activates	gene	0.60
ALS-CAUSING MUTATIONS	activates	gene	0.60
ATG	activates	gene	0.60
GENES	activates	gene	0.60
DNA	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
ALS	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Ceramide-Sphingosine-1-Phosphate Axis Rebalancing via SPHK1	0.000	-	Lipid metabolism dysregulation and membr

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 22 hypotheses Top: 0.852

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (5)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning SPHK1 in their description or question text

No additional research found