concept

LPCAT3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LPCAT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

70Connections

3Hypotheses

1Analyses

47Outgoing

23Incoming

1Experiments

8Debates

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💡 Concept Info

Name	LPCAT3
Key Genes/Proteins	ACSL4, ALOX5, AMYLOID, APP, arachidonoyl-CoA, ATF4
Related Diseases	Als, ALS, Diabetes
Related Pathways	Autophagy, ferroptosis
Linked Hypotheses	3 hypotheses

Pathway Diagram

graph TD
    LPCAT3["LPCAT3"]
    LPCAT3 -->|"activates"| LIPID_PEROXIDATION["LIPID_PEROXIDATION"]
    LPCAT3 -->|"activates"| Als["Als"]
    LPCAT3 -->|"activates"| Ms["Ms"]
    LPCAT3 -->|"inhibits"| Ischemia["Ischemia"]
    LPCAT3 -->|"inhibits"| Stroke["Stroke"]
    LPCAT3 -->|"activates"| Fibrosis["Fibrosis"]
    LPCAT3 -->|"activates"| Tumor["Tumor"]
    LPCAT3 -->|"activates"| ALS["ALS"]
    LPCAT3 -->|"regulates"| ACSL4["ACSL4"]
    ACSL4 -->|"regulates"| LPCAT3
    SPHK1["SPHK1"] -->|"interacts"| LPCAT3
    LOX["LOX"] -->|"inhibits"| LPCAT3
    FERROPTOSIS["FERROPTOSIS"] -->|"inhibits"| LPCAT3
    TFR1["TFR1"] -->|"inhibits"| LPCAT3
    GPX4["GPX4"] -->|"inhibits"| LPCAT3
    HK2["HK2"] -->|"activates"| LPCAT3
    ALOX5["ALOX5"] -->|"activates"| LPCAT3

Outgoing (47)

Target	Relation	Type	Str
Lands cycle remodeling	regulates	phenotype	0.90
arachidonoyl-CoA	regulates	gene	0.90
PUFA-PE	causes	gene	0.90
ferroptotic vulnerability	causes	phenotype	0.90
LIPID_PEROXIDATION	activates	phenotype	0.72
disease-associated microglia	associated_with	cell_type	0.70
ferroptotic susceptibility	drives	phenotype	0.70
membrane PUFA enrichment	causes	process	0.70
ALS	activates	disease	0.65
Ischemia	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Fibrosis	activates	disease	0.65
Tumor	activates	disease	0.65
Diabetes	activates	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Als	regulates	disease	0.65
Ferroptosis	regulates	pathway	0.60
NOX	regulates	gene	0.60
ROS	activates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
ACSL4	regulates	gene	0.60
ferroptosis	regulates	process	0.60
NOX	activates	gene	0.60
POR	regulates	gene	0.60
MLKL	interacts_with	gene	0.60
GPX4	interacts_with	gene	0.60
POR	interacts_with	gene	0.60
Autophagy	interacts_with	pathway	0.60
SOAT1	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
APP	activates	gene	0.60
GSR	activates	gene	0.60
GPX4	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
VDAC2	activates	gene	0.60
DMT1	activates	gene	0.60
CYBB	activates	gene	0.60
ATF4	activates	gene	0.60
Ras	activates	protein	0.60
AMYLOID	activates	gene	0.60
ferroptosis	participates_in	pathway	0.60
Glycolysis	activates	pathway	0.60
Ferroptosis	activates	pathway	0.60
Ferroptosis	inhibits	pathway	0.60
unfolded protein response	participates_in	pathway	0.55

Incoming (23)

Source	Relation	Type	Str
h-var-e4cae9d286	targets_gene	hypothesis	0.90
h-var-c56b26facf	targets_gene	hypothesis	0.90
h-var-70a95f9d57	targets_gene	hypothesis	0.90
HK2	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
ALOX5	activates	gene	0.60
ACSL4	activates	gene	0.60
GPX4	interacts_with	gene	0.60
POR	interacts_with	gene	0.60
NRF2	activates	gene	0.60
HMOX1	activates	gene	0.60
ACSL4	regulates	gene	0.60
SPHK1	interacts_with	gene	0.60
LOX	inhibits	gene	0.60
ACSL4	inhibits	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
TFR1	inhibits	gene	0.60
GPX4	inhibits	gene	0.60
ROS	activates	gene	0.60
POR	regulates	gene	0.60
NOX	activates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
ferroptosis	regulates	phenotype	0.50

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferrop	0.777	alzheimers	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Sub	0.776	alzheimers	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vul	0.764	alzheimers	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-03 | 19 hypotheses Top: 0.891

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
bEV isolation and LPS quantification from human samples	clinical	Alzheimer's disease	0.800	0.00	human patients	proposed	N/A

Related Papers (13)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667]	Zhang D, Zhang W, Ming C, Gao X, Yuan H,	Neuron	2024
Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in [PMID:38412923]	["Zhang Tian-Ci", "Lin Yi-Can", "Sun Nin	Neurochemistry international	2024
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117]	Balusu S, De Strooper B	Acta neuropathologica	2024
Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Trea [PMID:37047492]	Unknown	Int J Mol Sci	2023
Ferroptosis Signaling Pathways: Alzheimer's Disease. [PMID:37257500]	Unknown		2023
A Bioinformatics Perspective on the Dysregulation of Ferroptosis and Ferroptosis [PMID:36438927]	Unknown		2022
Pathogenesis of Alzheimer's Disease. [PMID:36613544]	Unknown	Int J Mol Sci	2022
Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890]	Burillo J, Marqués P, Jiménez B, Gonzále	Cells	2021
Alzheimer's disease. [PMID:31753135]	["Soria Lopez, Jose A", "Gonz\u00e1lez,	Handbook of clinical neurology	2019
Alzheimer's disease. [PMID:28872215]	["Lane, C A", "Hardy, J", "Schott, J M"]	European journal of neurology	2018
Current understanding of Alzheimer's disease diagnosis and treatment. [PMID:30135715]	["Weller, Jason", "Budson, Andrew"]	F1000Research	2018
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169]	["Oakley, Holly", "Cole, Sarah L", "Loga	The Journal of neuroscience :	2006
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773]	["Hardy, John", "Selkoe, Dennis J"]	Science (New York, N.Y.)	2002