gene

MACF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MACF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

0Hypotheses

0Analyses

43Outgoing

2Incoming

Summary

MACF1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, activates, implicated in. Associated with Cancer, Carcinoma, Hepatocellular Carcinoma. Connected to 13 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	MACF1
Full Name	Microtubule-actin crosslinking factor 1
Aliases	ACF7, Spectraplakin
Chromosome	9p21.3
Function	is a massive ~620 kDa cytoskeletal protein that serves as a critical bridge between actin microfilaments and microtubules [1](https://pubmed.
Primary Expression	Brain (cortex, hippocampus, cerebellum), lung, kidney, testis
Molecular Weight	620 kDa
Amino Acids	5434 aa
Exons	93
Pathways	Epithelial-Mesenchymal Transition, Metastasis
UniProt ID	Q9UPV3
NCBI Gene ID	23499
Ensembl ID	ENSG00000127603
OMIM	608271
GeneCards	MACF1
Human Protein Atlas	MACF1
Associated Diseases	Cancer, Diabetes
Interactions	NRCAM, Raf, APOPTOSIS
KG Connections	45 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MACF1 — AlphaFold Q9UPV3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MACF1 — Microtubule-actin crosslinking factor 1

gene · 4087 words

→

Genes

index · 271 words

→

Pathway Diagram

graph TD
    MACF1["<b>MACF1</b>"]
    Tumor{"Tumor"}
    MACF1 -->|"expressed_in"| Tumor
    Hepatocellular_Carcinoma{"Hepatocellular Carcinoma"}
    MACF1 -->|"expressed_in"| Hepatocellular_Carcinoma
    Cancer{"Cancer"}
    MACF1 -->|"expressed_in"| Cancer
    Liver_Cancer{"Liver Cancer"}
    MACF1 -->|"expressed_in"| Liver_Cancer
    Carcinoma{"Carcinoma"}
    MACF1 -->|"expressed_in"| Carcinoma
    CANCER(["CANCER"])
    MACF1 -->|"expressed_in"| CANCER
    style MACF1 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (43)

Target	Relation	Type	Str
Tumor	expressed_in	disease	0.65
Hepatocellular Carcinoma	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Liver Cancer	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
Diabetes	causes	disease	0.65
MYC	expressed_in	gene	0.60
NRCAM	activates	gene	0.60
CHRNE	causes	gene	0.60
DES	causes	gene	0.60
PHB2	associated_with	gene	0.60
SYNJ1	associated_with	gene	0.60
DES	associated_with	gene	0.60
Rb	associated_with	protein	0.60
NOTCH2	causes	gene	0.60
PPARG	causes	gene	0.60
GBM	causes	gene	0.60
Rb	causes	protein	0.60
HSP90AA1	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
CCNH	associated_with	gene	0.60
Rb	expressed_in	protein	0.60
CANCER	expressed_in	gene	0.60
Metastasis	activates	pathway	0.60
Invasion	expressed_in	pathway	0.60
Stem Cell	expressed_in	pathway	0.60
Epithelial-Mesenchymal Transition	activates	pathway	0.60
Ras	causes	protein	0.60
DNA	associated_with	gene	0.60
Mtor	expressed_in	pathway	0.60
Akt	expressed_in	protein	0.60
Ras	expressed_in	protein	0.60
Glycolysis	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Raf	inhibits	protein	0.60
Actin	associated_with	protein	0.60
MICROTUBULES	associated_with	gene	0.60
Fus	associated_with	protein	0.60
GLIOBLASTOMA	causes	gene	0.60
BMP	causes	gene	0.60
Notch	causes	pathway	0.60
App	causes	protein	0.60

Incoming (2)

Source	Relation	Type	Str
MAP1B	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found