concept

BMP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BMP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

99Connections

1Hypotheses

0Analyses

50Outgoing

32Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	BMP
Key Genes/Proteins	BDNF, MTOR
Related Diseases	Cranial Suture Patency, Pulmonary Arterial Hypertension, Inflammation, Parkinson, ALS
Related Pathways	Wnt, oxidative stress response
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    BMP["BMP"]
    BMP -->|"involved_in"| Cranial_Suture_Patency["Cranial Suture Patency"]
    BMP -->|"interacts"| MTOR["MTOR"]
    BMP -->|"activates"| Inflammation["Inflammation"]
    BMP -->|"inhibits"| Parkinson["Parkinson"]
    BMP -->|"inhibits"| ALS["ALS"]
    BMP -->|"causes"| Neuroinflammation["Neuroinflammation"]
    BMP -->|"causes"| Als["Als"]
    BMP -->|"causes"| Diabetes["Diabetes"]
    Wnt["Wnt"] -->|"interacts"| BMP
    AMPK["AMPK"] -->|"activates"| BMP
    MTOR -->|"activates"| BMP
    SIRT1["SIRT1"] -->|"activates"| BMP
    NLRP3["NLRP3"] -->|"activates"| BMP
    PI3K["PI3K"] -->|"activates"| BMP
    ACVR1["ACVR1"] -->|"activates"| BMP
    AKT["AKT"] -->|"activates"| BMP

Outgoing (67)

Target	Relation	Type	Str
Cranial Suture Patency	involved_in	phenotype	0.85
vascular remodeling	modulates	process	0.80
Pulmonary Arterial Hypertension	involved_in	disease	0.75
neurons	expressed_in	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
MTOR	interacts_with	gene	0.65
Inflammation	activates	disease	0.65
Parkinson	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Neuroinflammation	causes	disease	0.65
Als	causes	disease	0.65
Diabetes	causes	disease	0.65
Glioblastoma	causes	disease	0.65
NF-KB	activates	gene	0.60
SOX9	activates	gene	0.60
Inflammasome	activates	pathway	0.60
Nf-Kb	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
Mtor	activates	pathway	0.60
Stem Cell	activates	cell_type	0.60
Macrophage	activates	cell_type	0.60
PI3K	activates	gene	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
MTOR	activates	gene	0.60
NLRP3	activates	gene	0.60
Osteoblast	activates	cell_type	0.60
Actin	activates	protein	0.60
AKT	activates	gene	0.60
AMPK	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
SIRT1	activates	gene	0.60
AND	activates	gene	0.60
Insulin Signaling	inhibits	pathway	0.60
Dna Repair	associated_with	pathway	0.60
Epigenetic	associated_with	pathway	0.60
T Cell	associated_with	cell_type	0.60
Insulin	inhibits	protein	0.60
Wnt	activates	pathway	0.60
Mast Cell	causes	cell_type	0.60
T Cell	causes	cell_type	0.60
App	activates	protein	0.60
Rb	activates	protein	0.60
Akt	activates	protein	0.60
Notch	causes	pathway	0.60
Rb	causes	protein	0.60
App	causes	protein	0.60
NF-kB signaling	participates_in	pathway	0.60
LRRK2	inhibits	gene	0.60

Incoming (32)

Source	Relation	Type	Str
BDNF	downregulates	protein	0.90
Wnt	interacts_with	pathway	0.80
AMPK	activates	gene	0.60
MTOR	activates	gene	0.60
SIRT1	activates	gene	0.60
NLRP3	activates	gene	0.60
PI3K	activates	gene	0.60
ACVR1	activates	gene	0.60
AKT	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
NF-ΚB	activates	gene	0.60
SOX9	activates	gene	0.60
AND	activates	gene	0.60
LYSOSOME	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60
LRRK2	inhibits	gene	0.60
AND	inhibits	gene	0.60
DNA	associated_with	gene	0.60
PI3K	inhibits	gene	0.60
MUTYH	associated_with	gene	0.60
TAK1	activates	gene	0.60
SMAD4	activates	gene	0.60
MACF1	causes	gene	0.60
GLIOBLASTOMA	causes	gene	0.60
NOTCH2	causes	gene	0.60
PPARG	causes	gene	0.60
GBM	causes	gene	0.60
APOE4	activates	gene	0.60
APOE3	associated_with	gene	0.60
APOE4	associated_with	gene	0.60
ATP13A2	regulates	gene	0.60
ATP13A2	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
BMP4 Pathway Inhibition for Oligodendrocyte Myelination Supp	0.454	neurodegeneration	Cell type vulnerability in Alzheimer's D

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (2)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
ANGPTL4 regulates the adipogenic-osteogenic differentiation balance of bone marr [PMID:41482017]	Huang F, Zhu Z, Xing Q, Li M	Biochimie	2026	0
BMP4 dose dictates lineage specification bias in human periodontal ligament stem [PMID:41568233]	Li Y, Tang Q, Li L, Lin C, Guo M et al.	Front Bioeng Biotechnol	2025	0

BMP

Understanding Entity Pages

Wiki Pages (20)

Spinal Cord Dorsal Horn Neurons

Astrocytes

Neurogenesis

TGF-β Signaling in Parkinson's Disease

TBX2 — T-Box Transcription Factor 2

WNT7A Gene

Demyelination

lmx1b

Schwann Cells in Peripheral Neuropathy

Ubiquitin-Proteasome System Dysfunction in Parkinson's Disease

Tanycytes

Adult Neurogenesis in Neurodegeneration

GPR161 — G Protein-Coupled Receptor 161

Hedgehog Signaling in Neurodegeneration

SMAD3 — SMAD Family Member 3

Autophagy-Lysosomal Pathway

LHX2 — LIM Homeobox 2

BMPR2 Gene