SIGLEC1

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIGLEC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

SIGLEC1 (Sialic Acid-Binding Ig-Like Lectin 1), also known as CD169 or Siglec-1, is a cell surface receptor expressed on macrophages and involved in immune recognition, neuroinflammation, and neurodegenerative disease pathogenesis.

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graph TD
    SIGLEC1["<b>SIGLEC1</b>"]
    Diabetes{"Diabetes"}
    SIGLEC1 -->|"therapeutic target"| Diabetes
    Als{"Als"}
    SIGLEC1 -->|"therapeutic target"| Als
    Atherosclerosis{"Atherosclerosis"}
    SIGLEC1 -->|"therapeutic target"| Atherosclerosis
    Aging{"Aging"}
    SIGLEC1 -->|"therapeutic target"| Aging
    Ms{"Ms"}
    SIGLEC1 -->|"therapeutic target"| Ms
    SPR["SPR"]
    SIGLEC1 -->|"therapeutic target"| SPR
    Jak_Stat(["Jak-Stat"])
    SIGLEC1 -->|"therapeutic target"| Jak_Stat
    Nf__b(["Nf-Kappab"])
    SIGLEC1 -->|"therapeutic target"| Nf__b
    Mapk(["Mapk"])
    SIGLEC1 -->|"associated with"| Mapk
    NF__B["NF-KappaB"]
    SIGLEC1 -->|"therapeutic target"| NF__B
    DIABETES_MELLITUS["DIABETES MELLITUS"]
    SIGLEC1 -->|"therapeutic target"| DIABETES_MELLITUS
    APOE["APOE"]
    SIGLEC1 -->|"therapeutic target"| APOE
    MAPK10["MAPK10"]
    MAPK10 -->|"associated with"| SIGLEC1
    GENES["GENES"]
    GENES -->|"therapeutic target"| SIGLEC1
    APOE -->|"therapeutic target"| SIGLEC1
    AGING["AGING"]
    AGING -->|"therapeutic target"| SIGLEC1
    JAK["JAK"]
    JAK -->|"therapeutic target"| SIGLEC1
    style SIGLEC1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0