gene

VALOSIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VALOSIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

214Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

VALOSIN is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with Als, Alzheimer, Amyotrophic Lateral Sclerosis. Connected to 130 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	VCP
Full Name	Valosin-Containing Protein
Chromosome	9p13.3
Protein Family	AAA+ ATPase family
Protein Type	Enzyme
Target Class	Enzyme
Function	Small molecule inhibitors of VCP ATPase activity affecting protein quality control
Mechanism of Action	Small molecule inhibitors of VCP ATPase activity affecting protein quality control
Primary Expression	Ubiquitous - Brain, Muscle, Spinal cord
Subcellular Localization	Cytoplasm, nucleus, ER, mitochondria
Druggability	Medium (0.50)
Clinical Stage	Phase I
Molecular Weight	97 kDa
Amino Acids	806 aa
Exons	17
Pathways	Akt, Autophagy, Er Stress, Mitophagy, Ubiquitin-Proteasome
UniProt ID	P55072
Ensembl ID	ENSG00000165280
GeneCards	VCP
Human Protein Atlas	VCP
Associated Diseases	ALS, AMI, AUTOPHAGY, Alzheimer, Alzheimer's Disease
Known Drugs/Compounds	RAPAMYCIN, rapamycin
Interactions	TBK1, CHMP2B, OVERVIEW, VALOSIN, JUN, RANK
SciDEX Target	View Target Profile (4 clinical trials)
SciDEX Hypotheses	VCP-Mediated Autophagy Enhancement
KG Connections	915 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    VALOSIN["VALOSIN"]
    VALOSIN -->|"regulates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    VALOSIN -->|"regulates"| Ms["Ms"]
    VALOSIN -->|"regulates"| Dementia["Dementia"]
    VALOSIN -->|"activates"| Neurodegeneration["Neurodegeneration"]
    VALOSIN -->|"activates"| Als["Als"]
    VALOSIN -->|"regulates"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    JUN["JUN"] -->|"regulates"| VALOSIN
    SPHK1["SPHK1"] -->|"activates"| VALOSIN
    TARDBP["TARDBP"] -->|"activates"| VALOSIN
    PINK1["PINK1"] -->|"activates"| VALOSIN
    LC3["LC3"] -->|"activates"| VALOSIN
    MTOR["MTOR"] -->|"activates"| VALOSIN
    PTEN["PTEN"] -->|"activates"| VALOSIN
    VCP["VCP"] -->|"activates"| VALOSIN
    TBK1["TBK1"] -->|"activates"| VALOSIN
    CHMP2B["CHMP2B"] -->|"activates"| VALOSIN

Outgoing (123)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Ms	regulates	disease	0.65
Dementia	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ms	activates	disease	0.65
Dementia	activates	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Frontotemporal Dementia	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Frontotemporal Dementia	activates	disease	0.65
Ftd	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Stroke	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
VCP	associated_with	gene	0.60
JUN	regulates	gene	0.60
G3BP1	associated_with	gene	0.60
LC3	activates	gene	0.60
TBK1	activates	gene	0.60
NLRP3	expressed_in	gene	0.60
UBIQUITIN	associated_with	gene	0.60
PTEN	activates	gene	0.60
SPHK1	activates	gene	0.60
PINK1	activates	gene	0.60
TARDBP	activates	gene	0.60
TFEB	activates	gene	0.60
OPTN	associated_with	gene	0.60
OPTINEURIN	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
TIA1	associated_with	gene	0.60
HNRNPA2B1	associated_with	gene	0.60
VCP	activates	gene	0.60
MTOR	activates	gene	0.60
OVERVIEW	activates	gene	0.60
CHMP2B	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
HNRNPA1	associated_with	gene	0.60
VCP	expressed_in	gene	0.60
VCP	inhibits	gene	0.60
SOD1	inhibits	gene	0.60
VCP	degrades	entity	0.60

Incoming (91)

Source	Relation	Type	Str
JUN	regulates	gene	0.60
G3BP1	associated_with	gene	0.60
SPHK1	activates	gene	0.60
TARDBP	activates	gene	0.60
PINK1	activates	gene	0.60
LC3	activates	gene	0.60
MTOR	activates	gene	0.60
PTEN	activates	gene	0.60
VCP	activates	gene	0.60
TBK1	activates	gene	0.60
CHMP2B	activates	gene	0.60
OVERVIEW	activates	gene	0.60
OPTN	associated_with	gene	0.60
VCP	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
TIA1	associated_with	gene	0.60
HNRNPA2B1	associated_with	gene	0.60
HNRNPA1	associated_with	gene	0.60
TFEB	activates	gene	0.60
VCP	expressed_in	gene	0.60
UBIQUITIN	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
OPTINEURIN	associated_with	gene	0.60
BECN1	interacts_with	gene	0.60
VCP	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
G3BP1	degrades	entity	0.60
TDP-43	activates	gene	0.60
OPTINEURIN	activates	gene	0.60
MAP1LC3	activates	gene	0.60
ALS-CAUSING MUTATIONS	activates	gene	0.60
ATG	activates	gene	0.60
GENES	activates	gene	0.60
DNA	activates	gene	0.60
GENES	associated_with	gene	0.60
ALS-CAUSING MUTATIONS	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
NEURON	activates	gene	0.60
DEMENTIA	regulates	gene	0.60
AUTOPHAGY	activates	gene	0.60
ALS	activates	gene	0.60
DEMENTIA	activates	gene	0.60
NEURON	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
MATR3	associated_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

VALOSIN

Understanding Entity Pages

Summary

Wiki Pages (21)

VCP — Valosin-Containing Protein

Frontotemporal Dementia (FTD) Mechanistic Pathway

Frontotemporal Dementia (FTD)

HNRNPA2B1 Protein

ubiquitin-proteasome-dysfunction-neurodegeneration

Mitophagy Pathway in Neurodegeneration

Ion Channel Dysfunction in Frontotemporal Dementia

ALS RNA Metabolism and Proteostasis Failure

Mechanistic Proposal: Pathologic synergy: The pathologic aggregation of...

atxn3-protein

Tau Proteostasis and Clearance Across 4R-Tauopathies

HNRNPA1 Protein

autophagy-lysosomal-impairment-comparison

Membrane Trafficking Pathway Dysfunction in Neurodegeneration

Amyotrophic Lateral Sclerosis Hypothesis Rankings

VCP→TDP-43→ALS/FTD Causal Chain

Section 102: Proteostasis Network Dysregulation in CBS/PSP

Proteostasis Therapy CBS PSP

ALS-FTD-Parkinsonism Comparison Matrix