gene

NEFM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEFM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

51Connections

0Hypotheses

0Analyses

30Outgoing

21Incoming

Summary

Page for NEFM — Neurofilament Medium Chain

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🧬 Gene Info

Gene Symbol	NEFM
Full Name	Neurofilament Medium Chain
Chromosome	8q21.3
Function	The NEFM gene encodes the 102.5 kDa neurofilament medium polypeptide, which assembles with neurofilament light chain (NEFL) and heavy chain (NEFH) to form the neuronal intermediate filament cytoskelet
Primary Expression	Motor neurons, Sensory neurons, Spinal cord, Brainstem, Hippocampus, Cerebral cortex
Molecular Weight	102.5 kDa
UniProt ID	P12036
NCBI Gene ID	4741
Ensembl ID	ENSG00000104722
OMIM	162400
GeneCards	NEFM
Human Protein Atlas	NEFM
Interactions	RGS4, NEFL, CNR1, NFM, NPY, POMC
KG Connections	51 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NEFM — AlphaFold P12036 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NEFM["<b>NEFM</b>"]
    Alzheimer{"Alzheimer"}
    NEFM -->|"expressed_in"| Alzheimer
    CNR1(["CNR1"])
    NEFM -->|"regulates"| CNR1
    TAU(["TAU"])
    NEFM -->|"expressed_in"| TAU
    Amyloid["Amyloid"]
    NEFM -->|"expressed_in"| Amyloid
    ALZHEIMER(["ALZHEIMER"])
    NEFM -->|"expressed_in"| ALZHEIMER
    AMYLOID(["AMYLOID"])
    NEFM -->|"expressed_in"| AMYLOID
    NEFL(["NEFL"])
    NEFL -->|"regulates"| NEFM
    RGS4(["RGS4"])
    RGS4 -->|"regulates"| NEFM
    style NEFM fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (30)

Target	Relation	Type	Str
NEURODEGENERATIVE DISEASES	involved_in	disease	0.95
Amyotrophic Lateral Sclerosis	involved_in	disease	0.90
Alzheimer	expressed_in	disease	0.65
CNR1	regulates	gene	0.60
TAU	expressed_in	gene	0.60
RGS4	regulates	gene	0.60
NEFL	regulates	gene	0.60
Transferrin	regulates	protein	0.60
Rb	regulates	protein	0.60
NFM	activates	gene	0.60
NPY	activates	gene	0.60
POMC	activates	gene	0.60
PRKN	activates	gene	0.60
RBFOX3	activates	gene	0.60
Amyloid	expressed_in	pathway	0.60
ALZHEIMER	expressed_in	gene	0.60
AMYLOID	expressed_in	gene	0.60
Amyloid Beta	expressed_in	protein	0.60
Tau Protein	expressed_in	protein	0.60
Collagen	regulates	protein	0.60
Ras	regulates	protein	0.60
App	expressed_in	protein	0.60
RAS	regulates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
RNA	activates	gene	0.60
RGS4	interacts_with	gene	0.50
NEFL	interacts_with	gene	0.50
CNR1	interacts_with	protein	0.50
ERBB2	interacts_with	concept	0.50

Incoming (21)

Source	Relation	Type	Str
NEFL	regulates	gene	0.60
RGS4	regulates	gene	0.60
TAU	expressed_in	gene	0.60
CNR1	regulates	gene	0.60
AIF1	activates	gene	0.60
ARC	activates	gene	0.60
CAMKK2	activates	gene	0.60
COX4I1	activates	gene	0.60
GFAP	activates	gene	0.60
IBA1	activates	gene	0.60
LAMP2	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
AMYLOID	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
ERBB2	regulates	gene	0.60
GENES	regulates	gene	0.60
AND	regulates	gene	0.60
RAS	regulates	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
AMPK	activates	gene	0.60
LC3B	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NEFM

Understanding Entity Pages

Summary

Wiki Pages (21)

NEFM — Neurofilament Medium Chain

HNRNPH2 Gene

NEFL Gene

POU3F2 — POU Class 3 Homeobox 2

Cdk5 (Cyclin-Dependent Kinase 5)

Neurofilament Light Chain Protein

Neuronal Intermediate Filament Inclusion Bodies in Neurodegeneration

NEFL — Neurofilament Light Chain

Neurofilament Medium Chain (NfM) - Biomarker

Spinal Motor Neurons

Nucleus of the Brachium of the Superior Colliculus

Medial Terminal Nucleus (MTN)

Posterior Parietal Cortex Pyramidal Neurons

Dorsal Terminal Nucleus (DTN)

Hypoglossal Nucleus (CN XII) Motor Neurons

NEFH Protein

Neurofilament Light Chain (NF-L)

Gene Expression Atlas

NEFH Gene