concept

RAF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1295Connections

6Hypotheses

5Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	RAF
Key Genes/Proteins	MEK, HSP90-CDC37, SHOC2 phosphatase complex, RAS
Related Diseases	cancer, Ms, Cancer
Related Pathways	Mapk Pathway, oxidative stress response
Linked Hypotheses	8 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    RAF["RAF"]
    style RAF fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    RAF -->|"activates"| MEK([MEK])
    RAF -->|"target for"| Ms["Ms"]
    RAF -.->|"inhibits"| Cancer["Cancer"]
    RAF -->|"target for"| Aging["Aging"]
    RAF -->|"target for"| Lymphoma["Lymphoma"]
    RAF -->|"target for"| Tumor["Tumor"]
    RAF -->|"target for"| Als["Als"]
    RAF -->|"activates"| RAS([RAS])
    Vemurafenib{"Vemurafenib"} -.->|"inhibits"| RAF
    NST_628{"NST-628"} -->|"binds to"| RAF
    RAS -->|"activates"| RAF
    AKT([AKT]) -->|"activates"| RAF
    CANCER["CANCER"] -->|"activates"| RAF
    ERK([ERK]) -->|"activates"| RAF
    MTOR([MTOR]) -->|"activates"| RAF
    PI3K([PI3K]) -->|"activates"| RAF

Outgoing (317)

Target	Relation	Type	Str
MEK	activates	protein	0.95
Mapk Pathway	activates	pathway	0.95
MEK	phosphorylates	protein	0.90
cancer	associated_with	disease	0.85
oxidative stress response	participates_in	pathway	0.70
Ms	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
Aging	therapeutic_target	disease	0.65
Lymphoma	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Senescence	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Parkinson	activates	disease	0.65
Aging	activates	disease	0.65
Stroke	activates	disease	0.65
ALS	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Lymphoma	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Cancer	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Tumor	activates	disease	0.65
Carcinoma	activates	disease	0.65
RAS	activates	gene	0.60
STROKE	activates	disease	0.60
RAS	regulates	gene	0.60
PIK3CA	contributes_to	gene	0.60
AKT	contributes_to	gene	0.60
ERK	contributes_to	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
Akt	contributes_to	pathway	0.60
Mtor	contributes_to	pathway	0.60
Pi3K	contributes_to	pathway	0.60
Mapk	contributes_to	pathway	0.60
CANCER	activates	gene	0.60
JNK	regulates	gene	0.60
Oxidative Stress	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
Mapk	regulates	pathway	0.60
Autophagy	regulates	pathway	0.60
BRAF	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
PI3K	contributes_to	gene	0.60
CANCER	interacts_with	gene	0.60
KRAS	causes	gene	0.60

Incoming (978)

Source	Relation	Type	Str
Vemurafenib	inhibits	drug	0.90
HSP90-CDC37	interacts_with	protein	0.90
Dabrafenib	inhibits	drug	0.90
NST-628	binds_to	drug	0.88
SHOC2 phosphatase complex	activates	protein	0.85
RAS	activates	protein	0.80
NATURAL PRODUCTS	regulates	compound	0.80
RAS	regulates	protein	0.70
AKT	activates	gene	0.65
CANCER	activates	disease	0.65
ERK	activates	gene	0.65
MTOR	activates	gene	0.65
PI3K	activates	gene	0.65
CANCER	inhibits	disease	0.65
ALZHEIMER	activates	disease	0.60
ALZHEIMER'S	activates	disease	0.60
ALZHEIMER'S DISEASE	activates	disease	0.60
MAPK	activates	gene	0.60
PARKIN	activates	gene	0.60
PARKINSON	activates	disease	0.60
PARKINSON'S	activates	disease	0.60
PARKINSON'S DISEASE	activates	disease	0.60
MAPK	regulates	gene	0.60
NEURODEGENERATION	regulates	disease	0.60
GENES	contributes_to	gene	0.60
PI3K	contributes_to	gene	0.60
BRAF	inhibits	gene	0.60
RAS	contributes_to	gene	0.60
PTEN	contributes_to	gene	0.60
MTOR	contributes_to	gene	0.60
AND	inhibits	gene	0.60
MAPK	contributes_to	gene	0.60
CANCER	therapeutic_target	gene	0.60
PRMT5	therapeutic_target	gene	0.60
KRAS	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
LNCRNA	activates	gene	0.60
MIR31HG	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
P16	activates	gene	0.60
ERK	regulates	gene	0.60
STROKE	activates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
P38	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
JUN	regulates	gene	0.60
AND	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
C-JUN	regulates	gene	0.60

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Lysosomal Enzyme Trafficking Correction	0.489	neurodegeneration	Autophagy-lysosome pathway convergence a
TFAM overexpression creates mitochondrial donor-recipient gr	0.474	neurodegeneration	Mitochondrial transfer between astrocyte
Sphingomyelin Synthase Activators for Raft Remodeling	0.468	neurodegeneration	Lipid raft composition changes in synapt
APOE-Mediated Synaptic Lipid Raft Stabilization	0.426	neurodegeneration	Mechanistic role of APOE in neurodegener
Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy	0.426	neurodegeneration	Mitochondrial transfer between neurons a

Palmitoylation-Targeted BACE1 Trafficking Disruptors	0.407	neurodegeneration	Lipid raft composition changes in synapt

Mentioning Analyses (5)

Scientific analyses that reference this entity

How do sphingomyelin/ceramide ratios specifically regulate BACE1 clustering and

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.596

What are the specific molecular mechanisms by which peripheral monocytes cross t

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.584

What are the molecular determinants that control directional mitochondrial trans

cellular neuroscience | 2026-04-12 | 0 hypotheses

Systemic immune profiling and peripheral immune contributions to neurodegenerati

neurodegeneration | 2026-04-04 | 0 hypotheses

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.648

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Designed endocytosis-inducing proteins degrade targets and amplify signals. [PMID:39322662]	Huang B, Abedi M, Ahn G, Coventry B, Sap	Nature	2025	1
Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy t [PMID:37651673]	Deng Z, He M, Hu H, Zhang W, Zhang Y, Ge	Autophagy	2024	1
TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic [PMID:38783142]	Liu H, Zhen C, Xie J, Luo Z, Zeng L, Zha	Nat Cell Biol	2024	1
Collapse of late endosomal pH elicits a rapid Rab7 response via the V-ATPase and [PMID:38578235]	Mulligan RJ, Magaj MM, Digilio L, Redema	J Cell Sci	2024	1
IGF2 in memory, neurodevelopmental disorders, and neurodegenerative diseases. [PMID:37031050]	Alberini CM	Trends Neurosci	2023	1
Mitochondrial-derived damage-associated molecular patterns amplify neuroinflamma [PMID:35233090]	Lin MM, Liu N, Qin ZH, Wang Y	Acta Pharmacol Sin	2022	1
Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease. [PMID:33803217]	Chang CH, Lin CH, Lane HY	Int J Mol Sci	2021	1
Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic [PMID:33408785]	Zhao M, Wang Y, Li L, Liu S, Wang C, Yua	Theranostics	2021	1
Mitochondrial DNA copy number in human disease: the more the better? [PMID:33314045]	Filograna R, Mennuni M, Alsina D, Larsso	FEBS Lett	2021	1
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death. [PMID:32186434]	Li C, Zhang Y, Liu J, Kang R, Klionsky D	Autophagy	2021	1
Interactions of IGF-II with the IGF2R/cation-independent mannose-6-phosphate rec [PMID:19251056]	Brown J, Jones EY, Forbes BE	Vitam Horm	2009	1
Blocking palmitoyl-transferase activity reduces BACE1 membrane localization and [PMID:23395894]	Unknown	Molecular Neurodegeneration		0
Amyloid-β fibrils accumulated in preeclamptic placentas suppress cytotrophoblast [PMID:41558820]	Nishioka K, Ikezaki M, Iwahashi N, Araka	Life Sci Alliance	2026	0
An anti-inflammatory neuroenhancer mitigates amyloid-β pathology to improve Alzh [PMID:41696149]	Fang W, Zhao J, Li L, Wang Y, Xu ZP et a	Mater Today Bio	2026	0
Anti-ASC antibodies alleviate Alzheimer's disease-type pathology in APP/PS1 mice [PMID:41707905]	He L, Xiaopeng Z, Juan D, Yan L	Neuroscience	2026	0
Intranasal administration of neural stem cell-derived extracellular vesicles pre [PMID:41923110]	Natale F, Dellaria A, Nifo Sarrapochiell	Alzheimer's research & therapy	2026	0
Salvianolic acid a inhibits neuroinflammation and ameliorates Alzheimer's diseas [PMID:41930874]	Xiao S, Han Y, Yan J, Wu L, Lin H et al.	Int Immunopharmacol	2026	0
Repurposing FDA-approved drugs as multi-target neuroprotective agents for Alzhei [PMID:41946775]	Phemphunananchai K, Waiwut P, Phetcharab	Scientific reports	2026	0
Nano-magnolol enhances the modulatory effects of magnolol on cognitive performan [PMID:41954680]	Youssef B, Ibrahim EA, Moselhy SS, ElShe	Discov Nano	2026	0
BACE-1 inhibitors as potential drug candidates for treatment of Alzheimer's dise [PMID:41966670]	Kaur N, Gupta S, Bansal G, Bansal Y	Mol Divers	2026	0

RAF

Understanding Entity Pages

Wiki Pages (20)

NTF4 Protein

TREM2 Mechanism Hub

Neurotrophin Signaling Pathways in Neurodegeneration

VEGF/Angiogenesis Pathway in Neurodegeneration

nf1-protein

IGF-1 Signaling Pathway in Neurodegeneration

CNTF Signaling Pathway in Neurodegeneration

RASGRP1 Gene

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

Type 3 Diabetes Hypothesis of Alzheimer's Disease

CNTFR Gene

EPHA7 Gene

EPHA6 — Ephrin Type-A Receptor 6

LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

BDNF/Neurotrophin Signaling in Neurodegeneration

MAPK9 Gene

vip-vasoactive-intestinal-peptide-signaling-neurodegeneration

FGF Signaling Pathway in Neurodegeneration

MAPK/ERK Signaling Pathway in Neurodegeneration

EPHA8 Gene