gene

SYT2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections
0Hypotheses
0Analyses
19Outgoing
11Incoming

Summary

SYT2 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with Aging, Inflammation, Ms. Connected to 31 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSYT2
Full NameSynaptotagmin-2
Chromosome1q21.3
FunctionThe SYT2 gene encodes Synaptotagmin-2 (Syt2), a member of the synaptotagmin family of calcium-binding proteins.
UniProt IDQ9H0Y5
NCBI Gene ID11044
Ensembl IDENSG00000138294
GeneCardsSYT2
Human Protein AtlasSYT2
DiseaseAssociation Type
Myasthenia GravisAutoimmune Target
ALSRisk Modulator
Parkinson's DiseaseRisk Modulator
Congenital Myasthenic SyndromeCausative
ApproachStatus
Associated Diseasesneurodegeneration
KG Connections30 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: SYT2 — AlphaFold Q9H0Y5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

SYT2 Gene

gene · 726 words

Synaptic Vesicle Trafficking

mechanism · 3062 words

syt10

gene · 2829 words

SYT9 Gene

gene · 2776 words

SYT5 Gene

gene · 2693 words

Synaptic Vesicle Cycle

cell_type · 2471 words

Pathway Diagram

graph TD
    SYT2["<b>SYT2</b>"]
    Inflammation{"Inflammation"}
    SYT2 -->|"activates"| Inflammation
    Aging{"Aging"}
    SYT2 -->|"activates"| Aging
    Ms{"Ms"}
    SYT2 -->|"activates"| Ms
    ANTIOXIDANT_GENES["ANTIOXIDANT GENES"]
    SYT2 -->|"regulates"| ANTIOXIDANT_GENES
    TNF["TNF"]
    SYT2 -->|"regulates"| TNF
    SOD2["SOD2"]
    SYT2 -->|"regulates"| SOD2
    NOS2["NOS2"]
    SYT2 -->|"regulates"| NOS2
    P2RX3["P2RX3"]
    SYT2 -->|"regulates"| P2RX3
    RELA["RELA"]
    SYT2 -->|"regulates"| RELA
    SYP["SYP"]
    SYT2 -->|"regulates"| SYP
    CHRNA7["CHRNA7"]
    SYT2 -->|"regulates"| CHRNA7
    SYT1["SYT1"]
    SYT2 -->|"regulates"| SYT1
    PANX1["PANX1"]
    PANX1 -->|"regulates"| SYT2
    S100B["S100B"]
    S100B -->|"regulates"| SYT2
    RELB["RELB"]
    RELB -->|"regulates"| SYT2
    P2RY1["P2RY1"]
    P2RY1 -->|"regulates"| SYT2
    CASP3["CASP3"]
    CASP3 -->|"regulates"| SYT2
    SOCS3["SOCS3"]
    SOCS3 -->|"regulates"| SYT2
    TRPA1["TRPA1"]
    TRPA1 -->|"regulates"| SYT2
    GENES["GENES"]
    GENES -->|"regulates"| SYT2
    CXCL2["CXCL2"]
    CXCL2 -->|"regulates"| SYT2
    SNAP25["SNAP25"]
    SNAP25 -->|"regulates"| SYT2
    P2RX7["P2RX7"]
    P2RX7 -->|"regulates"| SYT2
    style SYT2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (19)

TargetRelationTypeStr
Inflammationactivatesdisease0.65
Agingactivatesdisease0.65
Msactivatesdisease0.65
TNFregulatesgene0.60
SOD2regulatesgene0.60

Incoming (11)

SourceRelationTypeStr
PANX1regulatesgene0.60
S100Bregulatesgene0.60
RELBregulatesgene0.60
P2RY1regulatesgene0.60
CASP3regulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found