Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SYT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SYT2 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with Aging, Inflammation, Ms. Connected to 31 entities in the SciDEX knowledge graph.
| Gene Symbol | SYT2 |
| Full Name | Synaptotagmin-2 |
| Chromosome | 1q21.3 |
| Function | The SYT2 gene encodes Synaptotagmin-2 (Syt2), a member of the synaptotagmin family of calcium-binding proteins. |
| UniProt ID | Q9H0Y5 |
| NCBI Gene ID | 11044 |
| Ensembl ID | ENSG00000138294 |
| GeneCards | SYT2 |
| Human Protein Atlas | SYT2 |
| Disease | Association Type |
| Myasthenia Gravis | Autoimmune Target |
| ALS | Risk Modulator |
| Parkinson's Disease | Risk Modulator |
| Congenital Myasthenic Syndrome | Causative |
| Approach | Status |
| Associated Diseases | neurodegeneration |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SYT2["<b>SYT2</b>"]
Inflammation{"Inflammation"}
SYT2 -->|"activates"| Inflammation
Aging{"Aging"}
SYT2 -->|"activates"| Aging
Ms{"Ms"}
SYT2 -->|"activates"| Ms
ANTIOXIDANT_GENES["ANTIOXIDANT GENES"]
SYT2 -->|"regulates"| ANTIOXIDANT_GENES
TNF["TNF"]
SYT2 -->|"regulates"| TNF
SOD2["SOD2"]
SYT2 -->|"regulates"| SOD2
NOS2["NOS2"]
SYT2 -->|"regulates"| NOS2
P2RX3["P2RX3"]
SYT2 -->|"regulates"| P2RX3
RELA["RELA"]
SYT2 -->|"regulates"| RELA
SYP["SYP"]
SYT2 -->|"regulates"| SYP
CHRNA7["CHRNA7"]
SYT2 -->|"regulates"| CHRNA7
SYT1["SYT1"]
SYT2 -->|"regulates"| SYT1
PANX1["PANX1"]
PANX1 -->|"regulates"| SYT2
S100B["S100B"]
S100B -->|"regulates"| SYT2
RELB["RELB"]
RELB -->|"regulates"| SYT2
P2RY1["P2RY1"]
P2RY1 -->|"regulates"| SYT2
CASP3["CASP3"]
CASP3 -->|"regulates"| SYT2
SOCS3["SOCS3"]
SOCS3 -->|"regulates"| SYT2
TRPA1["TRPA1"]
TRPA1 -->|"regulates"| SYT2
GENES["GENES"]
GENES -->|"regulates"| SYT2
CXCL2["CXCL2"]
CXCL2 -->|"regulates"| SYT2
SNAP25["SNAP25"]
SNAP25 -->|"regulates"| SYT2
P2RX7["P2RX7"]
P2RX7 -->|"regulates"| SYT2
style SYT2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammation | activates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| TNF | regulates | gene | 0.60 |
| SOD2 | regulates | gene | 0.60 |
| NOS2 | regulates | gene | 0.60 |
| P2RX3 | regulates | gene | 0.60 |
| RELA | regulates | gene | 0.60 |
| SYP | regulates | gene | 0.60 |
| CHRNA7 | regulates | gene | 0.60 |
| SYT1 | regulates | gene | 0.60 |
| STAT3 | regulates | gene | 0.60 |
| HMOX1 | regulates | gene | 0.60 |
| TRPV1 | regulates | gene | 0.60 |
| P2RY2 | regulates | gene | 0.60 |
| FOXP3 | regulates | gene | 0.60 |
| TPH2 | regulates | gene | 0.60 |
| CCL3 | regulates | gene | 0.60 |
| ANTIOXIDANT GENES | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||