gene

RELB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RELB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

95Connections

0Hypotheses

0Analyses

50Outgoing

19Incoming

Summary

RELB is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, expressed in. Associated with Aging, Als, Breast Cancer. Connected to 83 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NF
Full Name	κB RelB Protein
Aliases	RELB
Protein Family	NF-κB transcription factors
Protein Type	Transcription Factor
Function	RELB is a NF-κB family member that primarily partners with p52 to form the non-canonical NF-κB pathway.
Primary Expression	glial cells and may have neuroprotective or inflammatory roles in the brain
Molecular Weight	66 kDa
Pathways	NF-κB, NF-κB Pathway, NF-κB pathway, NF-κB signaling, NFKB
UniProt ID	[Q02880](https://www.uniprot.org/uniprot/Q02880)
GeneCards	NF
Human Protein Atlas	NF
NF-κB inhibitors	Broad-spectrum anti-inflammatory
RELB-specific inhibitors	Targeted therapy
Gene therapy	Modulate RELB expression
Associated Diseases	Als, Cancer, Carcinoma, Lung Cancer, Melanoma, Tumor
Interactions	IGF1, RPS6KB1, TNF, NF-ΚB, CANCER, INFLAMMATION
KG Connections	95 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RELB["<b>RELB</b>"]
    Inflammation{"Inflammation"}
    RELB -->|"activates"| Inflammation
    Aging{"Aging"}
    RELB -->|"activates"| Aging
    Ms{"Ms"}
    RELB -->|"activates"| Ms
    RELB -->|"expressed in"| Inflammation
    P2RY1["P2RY1"]
    RELB -->|"regulates"| P2RY1
    CASP3["CASP3"]
    RELB -->|"regulates"| CASP3
    SOCS3["SOCS3"]
    RELB -->|"regulates"| SOCS3
    TRPA1["TRPA1"]
    RELB -->|"regulates"| TRPA1
    GENES["GENES"]
    RELB -->|"regulates"| GENES
    CXCL2["CXCL2"]
    RELB -->|"regulates"| CXCL2
    SNAP25["SNAP25"]
    RELB -->|"regulates"| SNAP25
    P2RX7["P2RX7"]
    RELB -->|"regulates"| P2RX7
    PANX1["PANX1"]
    PANX1 -->|"regulates"| RELB
    S100B["S100B"]
    S100B -->|"regulates"| RELB
    style RELB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (76)

Target	Relation	Type	Str
Als	activates	disease	0.85
Inflammation	activates	disease	0.75
Cancer	activates	disease	0.75
Nf-Κb	activates	pathway	0.70
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Tumor	associated_with	disease	0.65
Melanoma	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Lung Cancer	associated_with	disease	0.65
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
P2RY1	regulates	gene	0.60
CASP3	regulates	gene	0.60
SOCS3	regulates	gene	0.60
TRPA1	regulates	gene	0.60
CXCL2	regulates	gene	0.60
SNAP25	regulates	gene	0.60
P2RX7	regulates	gene	0.60
SYT2	regulates	gene	0.60
TNF	regulates	gene	0.60
SOD2	regulates	gene	0.60
NOS2	regulates	gene	0.60
P2RX3	regulates	gene	0.60
RELA	regulates	gene	0.60
SYP	regulates	gene	0.60
CHRNA7	regulates	gene	0.60
SYT1	regulates	gene	0.60
STAT3	regulates	gene	0.60
HMOX1	regulates	gene	0.60
TRPV1	regulates	gene	0.60
P2RY2	regulates	gene	0.60
FOXP3	regulates	gene	0.60
TPH2	regulates	gene	0.60
CCL3	regulates	gene	0.60
IGF1	interacts_with	gene	0.60
APOE	expressed_in	gene	0.60
RPS6KB1	interacts_with	gene	0.60
NOTCH1	expressed_in	gene	0.60
TNF	activates	gene	0.60
MEF2C	causes	gene	0.60
STAT1	regulates	gene	0.60

Incoming (19)

Source	Relation	Type	Str
CANCER	activates	gene	0.70
PANX1	regulates	gene	0.60
S100B	regulates	gene	0.60
REL	expressed_in	gene	0.60
RELA	expressed_in	gene	0.60
REL	therapeutic_target	gene	0.60
RELA	therapeutic_target	gene	0.60
CXCL12	associated_with	gene	0.60
FOXM1	causes	gene	0.60
IL6	associated_with	gene	0.60
NR1H3	causes	gene	0.60
NF-ΚB	activates	gene	0.60
NF-KB	expressed_in	gene	0.60
NF-ΚB	interacts_with	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
INFLAMMATION	activates	gene	0.60
CANCER	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RELB

Understanding Entity Pages

Summary

Wiki Pages (21)

RELB Gene

NF-kB Signaling Pathway in Neurodegeneration

NF-κB Signaling Pathway in Neurodegeneration

nfkb-neurodegeneration

NF-κB Signaling in Neurodegeneration

Neuroinflammation in Neurodegeneration

LTBR Gene

fbxo38

S100 Protein Signaling Pathway in Neurodegeneration

NF-κB Pathway Inhibition for Neurodegeneration

c-Rel Protein

NF-κB Signaling in Neuroinflammation

NF-kB Pathway Inhibition Therapy for Neurodegeneration

ikkgamma

CHUK — IKK Alpha (IκB Kinase Alpha)

TACI Gene (TNFRSF13B)

nf-kb

RIPK1 Gene

LTBR Protein — Lymphotoxin Beta Receptor