gene

TRKA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRKA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

122Connections

0Hypotheses

0Analyses

50Outgoing

26Incoming

Summary

Page for TRKA Gene

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🧬 Gene Info

Gene Symbol	TRKA
Chromosome	1q23.1
Protein Family	Trk family (TrkA, TrkB, TrkC)
Protein Type	Receptor
Function	is a high-affinity receptor tyrosine kinase for nerve growth factor (NGF), encoded by the NTRK1 gene on chromosome 1q21-22.
Primary Expression	basal forebrain cholinergic neurons (BFCNs), which are the primary source of acetylcholine to the hippocampus and neocortex
Molecular Weight	140 kDa
Amino Acids	796 aa
Exons	17
Pathways	PI3K
GeneCards	TRKA
Human Protein Atlas	TRKA
Pathway	Primary Effect
PI3K/Akt	Pro-survival, protein synthesis
Ras/ERK	Differentiation, gene transcription
Associated Diseases	Alzheimer, Alzheimer'S Disease, Pain, disease
Interactions	NRP1, NGF, GAIN, BDNF, TRKC, TRKB
KG Connections	122 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TRKA["<b>TRKA</b>"]
    Alzheimer["Alzheimer"]
    TRKA -->|"associated with"| Alzheimer
    Alzheimer["Alzheimer"]
    TRKA -->|"inhibits"| Alzheimer
    Als["Als"]
    TRKA -->|"inhibits"| Als
    Aging["Aging"]
    TRKA -->|"inhibits"| Aging
    Alzheimer["Alzheimer"]
    TRKA -->|"therapeutic target"| Alzheimer
    ALS["ALS"]
    TRKA -->|"inhibits"| ALS
    NRP1["NRP1"]
    TRKA -->|"interacts with"| NRP1
    NGF["NGF"]
    TRKA -->|"interacts with"| NGF
    GAIN["GAIN"]
    TRKA -->|"inhibits"| GAIN
    AXON["AXON"]
    TRKA -->|"regulates"| AXON
    NEURON["NEURON"]
    TRKA -->|"regulates"| NEURON
    AND["AND"]
    TRKA -->|"regulates"| AND
    CASP3["CASP3"]
    TRKA -->|"regulates"| CASP3
    ERK["ERK"]
    TRKA -->|"phosphorylates"| ERK
    Neuron["Neuron"]
    TRKA -->|"associated with"| Neuron
    NGF["NGF"]
    TRKA -->|"activates"| NGF
    ALZHEIMER["ALZHEIMER"]
    TRKA -->|"inhibits"| ALZHEIMER
    MAPK["MAPK"]
    TRKA -->|"inhibits"| MAPK
    AGING["AGING"]
    TRKA -->|"inhibits"| AGING
    Mapk["Mapk"]
    TRKA -->|"inhibits"| Mapk
    Neuron["Neuron"]
    TRKA -->|"inhibits"| Neuron
    ALZHEIMER["ALZHEIMER"]
    TRKA -->|"therapeutic target"| ALZHEIMER
    NGF["NGF"]
    TRKA -->|"therapeutic target"| NGF
    MAO["MAO"]
    TRKA -->|"associated with"| MAO
    APOPTOSIS["APOPTOSIS"]
    TRKA -->|"associated with"| APOPTOSIS
    ALZHEIMER["ALZHEIMER"]
    TRKA -->|"associated with"| ALZHEIMER
    NTRK2["NTRK2"]
    TRKA -->|"associated with"| NTRK2
    BDNF["BDNF"]
    TRKA -->|"interacts with"| BDNF
    TRKC["TRKC"]
    TRKA -->|"interacts with"| TRKC
    TRKB["TRKB"]
    TRKA -->|"interacts with"| TRKB

Outgoing (96)

Target	Relation	Type	Str
Opioid	inhibits	disease	0.65
Chronic Pain	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
ALS	inhibits	disease	0.65
Neuropathy	transports	disease	0.65
Als	activates	disease	0.65
NRP1	interacts_with	gene	0.60
NGF	interacts_with	gene	0.60
GAIN	inhibits	gene	0.60
CASP3	regulates	gene	0.60
NGF	activates	gene	0.60
NGF	therapeutic_target	gene	0.60
NTRK2	associated_with	gene	0.60
BDNF	interacts_with	gene	0.60
TRKC	interacts_with	gene	0.60
TRKB	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
NGF	contributes_to	gene	0.60
TAU	regulates	gene	0.60
NGF	inhibits	gene	0.60
RET	regulates	gene	0.60
MAP1B	transports	gene	0.60
TAU	transports	gene	0.60
DYNEIN	transports	gene	0.60
TRKB	regulates	gene	0.60
TRKC	regulates	gene	0.60
Schwann Cell	transports	cell_type	0.60
Dynein	transports	protein	0.60
CRY2	activates	gene	0.60
AXON	regulates	gene	0.60
NEURON	regulates	gene	0.60
AND	regulates	gene	0.60
ERK	phosphorylates	protein	0.60
Neuron	associated_with	cell_type	0.60
ALZHEIMER	inhibits	gene	0.60
MAPK	inhibits	gene	0.60
AGING	inhibits	gene	0.60
Mapk	inhibits	pathway	0.60
Neuron	inhibits	cell_type	0.60
ALZHEIMER	therapeutic_target	gene	0.60
MAO	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
Apoptosis	associated_with	pathway	0.60
AND	contributes_to	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60

Incoming (26)

Source	Relation	Type	Str
NGF	binds_to	protein	0.60
NGF	contributes_to	gene	0.60
APP	interacts_with	gene	0.60
TAU	regulates	gene	0.60
AKT	inhibits	gene	0.60
NGF	therapeutic_target	gene	0.60
NGF	activates	gene	0.60
NGF	interacts_with	gene	0.60
IRF3	activates	gene	0.60
PERK	activates	gene	0.60
RORA	activates	gene	0.60
AMYLOID	therapeutic_target	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AGING	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
MYELIN	transports	gene	0.60
NEURON	activates	gene	0.60
CREB	activates	gene	0.60
ERBB2	activates	gene	0.60
IFN	activates	gene	0.60
BDNF	interacts_with	gene	0.50
TRKB	interacts_with	gene	0.50
TRKC	interacts_with	gene	0.50
NGF	co_expressed_with	gene	0.50
NTRK2	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TRKA

Understanding Entity Pages

Summary

Wiki Pages (21)

TRKA Gene

NTF4 Protein

Growth Factor Therapies

Neurotrophin Signaling Pathways in Neurodegeneration

Growth Factor Therapeutics: Investment Landscape Analysis

substance-p-nk1-signaling-neurodegeneration

Remyelination in Neurodegeneration

Neurotrophic Factors in Neurodegeneration

BDNF/Neurotrophin Signaling in Neurodegeneration

Section 103: Neurotrophic Factor Therapies in CBS/PSP

MAPK/ERK Signaling Pathway in Neurodegeneration

Apoptosis Pathway in Neurodegeneration

Neurotrophic Factor Signaling in Neurodegeneration

NT-4 Signaling Pathway in Neurodegeneration

Neurons

TrkB Protein

Retrograde Axonal Transport Dysfunction in Neurodegeneration

ERK1 Protein

p75NTR Protein