gene

TRKC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRKC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

73Connections

0Hypotheses

0Analyses

39Outgoing

34Incoming

Summary

Page for TRKC Gene

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🧬 Gene Info

Gene Symbol	TRKC
Chromosome	15q25.3
Protein Type	Receptor
Function	TrkC is the primary receptor for neurotrophin-3 (NT-3)
Primary Expression	proprioceptive neurons, motor neurons, and certain populations of hippocampal and cortical neurons
Molecular Weight	145 kDa
Amino Acids	821 aa
Exons	26
Pathways	signaling: - Supports sensory neuron survival, PI3K, MAPK
GeneCards	TRKC
Human Protein Atlas	TRKC
Approach	Stage
NT-3 protein	Clinical trials
Gene therapy	Preclinical
Small molecule agonists	Discovery
Associated Diseases	Alzheimer
Interactions	TRKB, TRKA, BDNF, NGF, ALZHEIMER, AMYLOID
KG Connections	73 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TRKC["<b>TRKC</b>"]
    Alzheimer["Alzheimer"]
    TRKC -->|"activates"| Alzheimer
    Alzheimer["Alzheimer"]
    TRKC -->|"associated with"| Alzheimer
    TRKB["TRKB"]
    TRKC -->|"regulates"| TRKB
    Synaptic_Plasticity["Synaptic Plasticity"]
    TRKC -->|"activates"| Synaptic_Plasticity
    Microglia["Microglia"]
    TRKC -->|"activates"| Microglia
    Neuron["Neuron"]
    TRKC -->|"activates"| Neuron
    TRKB["TRKB"]
    TRKC -->|"interacts with"| TRKB
    Apoptosis["Apoptosis"]
    TRKC -->|"associated with"| Apoptosis
    Neuron["Neuron"]
    TRKC -->|"associated with"| Neuron
    Amyloid["Amyloid"]
    TRKC -->|"activates"| Amyloid
    Long_Term_Potentiation["Long-Term Potentiation"]
    TRKC -->|"regulates"| Long_Term_Potentiation
    Long_Term_Potentiation["Long-Term Potentiation"]
    TRKC -->|"associated with"| Long_Term_Potentiation
    AMYLOID["AMYLOID"]
    AMYLOID -->|"activates"| TRKC
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"activates"| TRKC
    APP["APP"]
    APP -->|"regulates"| TRKC
    NEURON["NEURON"]
    NEURON -->|"activates"| TRKC
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| TRKC
    TRKA["TRKA"]
    TRKA -->|"interacts with"| TRKC
    MAO["MAO"]
    MAO -->|"associated with"| TRKC
    NGF["NGF"]
    NGF -->|"interacts with"| TRKC
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"associated with"| TRKC
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| TRKC
    NTRK2["NTRK2"]
    NTRK2 -->|"associated with"| TRKC
    BDNF["BDNF"]
    BDNF -->|"interacts with"| TRKC
    TRKB["TRKB"]
    TRKB -->|"regulates"| TRKC
    AND["AND"]
    AND -->|"regulates"| TRKC
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| TRKC
    TRKB["TRKB"]
    TRKB -->|"interacts with"| TRKC
    AND["AND"]
    AND -->|"interacts with"| TRKC
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| TRKC

Outgoing (39)

Target	Relation	Type	Str
Alzheimer	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Neuropathy	transports	disease	0.65
TRKB	regulates	gene	0.60
TRKB	interacts_with	gene	0.60
Schwann Cell	transports	cell_type	0.60
Dynein	transports	protein	0.60
APP	regulates	gene	0.60
NTRK2	associated_with	gene	0.60
BDNF	interacts_with	gene	0.60
NGF	interacts_with	gene	0.60
Synaptic Plasticity	activates	pathway	0.60
Microglia	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
Apoptosis	associated_with	pathway	0.60
Neuron	associated_with	cell_type	0.60
Amyloid	activates	pathway	0.60
Long-Term Potentiation	regulates	pathway	0.60
Long-Term Potentiation	associated_with	pathway	0.60
Neuron	encodes	cell_type	0.60
Amyloid Beta	activates	protein	0.60
Aβ	activates	protein	0.60
Myosin	associated_with	protein	0.60
Bdnf	interacts_with	protein	0.60
Ngf	interacts_with	protein	0.60
Neuron	transports	cell_type	0.60
MAO	associated_with	gene	0.60
App	associated_with	protein	0.60
Neuron	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55
TRKA	interacts_with	gene	0.50
ALZHEIMER	activates	gene	0.50
ALZHEIMER'S	activates	concept	0.50
AMYLOID	activates	gene	0.50
AMYLOID BETA	activates	concept	0.50
ALZHEIMER	regulates	gene	0.50
Alzheimer'S Disease	regulates	disease	0.50
disease	regulates	disease	0.50
ALZHEIMER'S	regulates	concept	0.50

Incoming (34)

Source	Relation	Type	Str
APP	regulates	gene	0.60
TRKA	interacts_with	gene	0.60
NGF	interacts_with	gene	0.60
NTRK2	associated_with	gene	0.60
BDNF	interacts_with	gene	0.60
TRKB	regulates	gene	0.60
TRKB	interacts_with	gene	0.60
TRKA	regulates	gene	0.60
RET	regulates	gene	0.60
MAP1B	transports	gene	0.60
TAU	transports	gene	0.60
DYNEIN	transports	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
NEURON	activates	gene	0.60
MICROGLIA	activates	gene	0.60
MAO	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
AND	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
NEURON	encodes	gene	0.60
MYELIN	transports	gene	0.60
AXON	transports	gene	0.60
ERK1/2	transports	gene	0.60
late	activates	disease	0.50
TRKB	activates	gene	0.50
late	regulates	disease	0.50
TRKB	associated_with	gene	0.50
TRKA	co_expressed_with	gene	0.50
TRKB	co_expressed_with	gene	0.50
microglia	activates	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TRKC

Understanding Entity Pages

Summary

Wiki Pages (21)

TRKC Gene

NTF4 Protein

Growth Factor Therapies

Neurotrophin Signaling Pathways in Neurodegeneration

Growth Factor Therapeutics: Investment Landscape Analysis

Neurotrophic Factors in Neurodegeneration

BDNF/Neurotrophin Signaling in Neurodegeneration

Section 103: Neurotrophic Factor Therapies in CBS/PSP

Neurotrophic Factor Signaling in Neurodegeneration

NT-4 Signaling Pathway in Neurodegeneration

TrkB Protein

Retrograde Axonal Transport Dysfunction in Neurodegeneration

p75NTR Protein

NTF5 — Neurotrophin 5

treg-regulatory-t-cell-therapy-parkinsons

neurotrophin-signaling-dysfunction-parkinsons

TrkB Protein

Dopaminergic VTA Neurons in Parkinson's Disease

NT-3 Signaling Pathway in Neurodegeneration