concept

TPRKB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TPRKB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

63Connections

0Hypotheses

0Analyses

35Outgoing

28Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	TPRKB
Key Genes/Proteins	TP53, MAPT, CDKN1A, AND, APOPTOSIS
Related Diseases	Dementia, Amyotrophic Lateral Sclerosis, ALS, Frontotemporal Dementia, Als

Pathway Diagram

graph TD
    TPRKB["TPRKB"]
    TPRKB -->|"expressed in"| Dementia["Dementia"]
    TPRKB -->|"expressed in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    TPRKB -->|"expressed in"| ALS["ALS"]
    TPRKB -->|"expressed in"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    TPRKB -->|"encodes"| Als["Als"]
    TBC1D24["TBC1D24"] -->|"expressed in"| TPRKB
    PLIN4["PLIN4"] -->|"expressed in"| TPRKB
    FUS["FUS"] -->|"expressed in"| TPRKB
    ATXN2["ATXN2"] -->|"expressed in"| TPRKB
    HNRNPA2B1["HNRNPA2B1"] -->|"expressed in"| TPRKB
    BID["BID"] -->|"expressed in"| TPRKB
    NEURON["NEURON"] -->|"expressed in"| TPRKB
    HNRNPA1["HNRNPA1"] -->|"expressed in"| TPRKB

Outgoing (35)

Target	Relation	Type	Str
Dementia	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Frontotemporal Dementia	expressed_in	disease	0.65
Frontotemporal Dementia	encodes	disease	0.65
Dementia	encodes	disease	0.65
Amyotrophic Lateral Sclerosis	encodes	disease	0.65
Als	encodes	disease	0.65
Spinal Muscular Atrophy	expressed_in	disease	0.65
MAPT	expressed_in	gene	0.60
CDKN1A	activates	gene	0.60
AND	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
SMN	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	0.60
TIA1	activates	gene	0.60
CNTN4	expressed_in	gene	0.60
Tdp-43	expressed_in	pathway	0.60
Apoptosis	activates	pathway	0.60
Er Stress	expressed_in	pathway	0.60
Cell Cycle	activates	pathway	0.60
TBC1D24	encodes	gene	0.60
BID	encodes	gene	0.60
Er Stress	encodes	pathway	0.60
Neuron	encodes	cell_type	0.60
Tdp-43	encodes	protein	0.60
HNRNPA1	expressed_in	gene	0.60
ATXN2	expressed_in	gene	0.60
FUS	expressed_in	gene	0.60
Raf	expressed_in	protein	0.60
Ca1	expressed_in	brain_region	0.55
Spinal Cord	expressed_in	brain_region	0.55
Cerebellum	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (28)

Source	Relation	Type	Str
TP53	associated_with	gene	0.80
TP53-deficient	associated_with	cell_type	0.80
TBC1D24	expressed_in	gene	0.60
PLIN4	expressed_in	gene	0.60
FUS	expressed_in	gene	0.60
ATXN2	expressed_in	gene	0.60
HNRNPA2B1	expressed_in	gene	0.60
BID	expressed_in	gene	0.60
NEURON	expressed_in	gene	0.60
HNRNPA1	expressed_in	gene	0.60
ALS	expressed_in	gene	0.60
CCNF	activates	gene	0.60
DEMENTIA	expressed_in	gene	0.60
TDP-43	expressed_in	gene	0.60
NEURON	encodes	gene	0.60
FUS	encodes	gene	0.60
PLIN4	encodes	gene	0.60
HNRNPA2B1	encodes	gene	0.60
ALS	encodes	gene	0.60
ATXN2	encodes	gene	0.60
HNRNPA1	encodes	gene	0.60
DEMENTIA	encodes	gene	0.60
CNTN4	encodes	gene	0.60
SMN	encodes	gene	0.60
MAPT	expressed_in	gene	0.60
SMN	expressed_in	gene	0.60
TIA1	activates	gene	0.60
APOPTOSIS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found