Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TUBB4B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TUBB4B is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, implicated in. Associated with Alzheimer, Huntington, Ms. Connected to 39 entities in the SciDEX knowledge graph.
| Gene Symbol | TUBB4B |
| Full Name | Tubulin Beta 4B Class IIa |
| Aliases | Page for TUBB4B |
| Chromosome | 9q34.3 |
| Function | TUBB4B encodes beta-tubulin isotype 4B, a structural component of microtubules. |
| Primary Expression | photoreceptor cells and retinal ganglion cells |
| Molecular Weight | 50 kDa |
| Amino Acids | 444 aa |
| Pathways | Akt, Cell Cycle, Pi3K |
| UniProt ID | P68371 |
| NCBI Gene ID | 10383 |
| Ensembl ID | ENSG00000144410 |
| OMIM | 191307 |
| GeneCards | TUBB4B |
| Human Protein Atlas | TUBB4B |
| Associated Diseases | Alzheimer, Huntington, Parkinson, Parkinson'S Disease, Prion |
| Interactions | NDUFA9, TUBB3, SLC6A3, TUBB, Prion, ALZHEIMER |
| KG Connections | 87 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TUBB4B["<b>TUBB4B</b>"]
Alzheimer{"Alzheimer"}
TUBB4B -->|"associated with"| Alzheimer
Ms{"Ms"}
TUBB4B -->|"regulates"| Ms
Parkinson{"Parkinson"}
TUBB4B -->|"regulates"| Parkinson
Huntington{"Huntington"}
TUBB4B -->|"associated with"| Huntington
TUBB4B -->|"associated with"| Parkinson
Prion_Disease{"Prion Disease"}
TUBB4B -->|"associated with"| Prion_Disease
NDUFA9["NDUFA9"]
TUBB4B -->|"associated with"| NDUFA9
Pi3K(["Pi3K"])
TUBB4B -->|"regulates"| Pi3K
Akt(["Akt"])
TUBB4B -->|"regulates"| Akt
AKT["AKT"]
TUBB4B -->|"regulates"| AKT
SNCA["SNCA"]
TUBB4B -->|"associated with"| SNCA
TUBB3["TUBB3"]
TUBB4B -->|"associated with"| TUBB3
TUBB["TUBB"]
TUBB -->|"associated with"| TUBB4B
SNCA -->|"associated with"| TUBB4B
TUBB3 -->|"associated with"| TUBB4B
SLC6A3["SLC6A3"]
SLC6A3 -->|"associated with"| TUBB4B
NDUFA9 -->|"associated with"| TUBB4B
PI3K["PI3K"]
PI3K -->|"regulates"| TUBB4B
GENES["GENES"]
GENES -->|"associated with"| TUBB4B
AKT -->|"associated with"| TUBB4B
PI3K -->|"associated with"| TUBB4B
AKT -->|"regulates"| TUBB4B
ALZHEIMER["ALZHEIMER"]
ALZHEIMER -->|"associated with"| TUBB4B
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"regulates"| TUBB4B
style TUBB4B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson's Disease | associated_with | disease | 0.80 |
| Parkinson'S Disease | associated_with | disease | 0.80 |
| Alzheimer | associated_with | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Parkinson | regulates | disease | 0.65 |
| Huntington | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Prion Disease | associated_with | disease | 0.65 |
| Prion | associated_with | disease | 0.65 |
| NDUFA9 | associated_with | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| SNCA | associated_with | gene | 0.60 |
| TUBB3 | associated_with | gene | 0.60 |
| SLC6A3 | associated_with | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| Rb | regulates | protein | 0.60 |
| neurodegeneration | interacts_with | disease | 0.60 |
| Pi3K | regulates | pathway | 0.60 |
| Akt | regulates | pathway | 0.60 |
| Akt | associated_with | pathway | 0.60 |
| Cell Cycle | associated_with | pathway | 0.60 |
| Pi3K | associated_with | pathway | 0.60 |
| SYNAPSE | regulates | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | associated_with | gene | 0.60 |
| HUNTINGTON | associated_with | gene | 0.60 |
| Cell Cycle | regulates | pathway | 0.60 |
| PARKINSON'S DISEASE | regulates | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| PARKINSON | regulates | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| Dopaminergic | regulates | cell_type | 0.60 |
| Α-Synuclein | associated_with | protein | 0.60 |
| Huntington's disease | interacts_with | disease | 0.60 |
| Alzheimer's disease | interacts_with | disease | 0.60 |
| NDUFA9 | interacts_with | gene | 0.50 |
| TUBB3 | interacts_with | gene | 0.50 |
| SLC6A3 | interacts_with | gene | 0.50 |
| TUBB | interacts_with | gene | 0.50 |
| Prion | interacts_with | protein | 0.50 |
| ALZHEIMER | interacts_with | gene | 0.50 |
| HUNTINGTON | interacts_with | gene | 0.50 |
| NEURODEGENERATIVE DISORDERS | interacts_with | concept | 0.50 |
| disease | interacts_with | disease | 0.50 |
| ALZHEIMER'S | interacts_with | concept | 0.50 |
| HUNTINGTON'S | interacts_with | concept | 0.50 |
| SYNUCLEIN | interacts_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TUBB | associated_with | gene | 0.60 |
| SNCA | associated_with | gene | 0.60 |
| TUBB3 | associated_with | gene | 0.60 |
| SLC6A3 | associated_with | gene | 0.60 |
| NDUFA9 | associated_with | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| AKT | associated_with | gene | 0.60 |
| PI3K | associated_with | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| NDUFA9 | regulates | entity | 0.60 |
| SLC6A3 | regulates | entity | 0.60 |
| SNCA | regulates | entity | 0.60 |
| TUBB | regulates | entity | 0.60 |
| TUBB3 | regulates | entity | 0.60 |
| NDUFA9 | interacts_with | gene | 0.60 |
| SLC6A3 | interacts_with | gene | 0.60 |
| TUBB | interacts_with | gene | 0.60 |
| TUBB3 | interacts_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | regulates | gene | 0.60 |
| PARKINSON | regulates | gene | 0.60 |
| SYNAPSE | regulates | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | associated_with | gene | 0.60 |
| HUNTINGTON | associated_with | gene | 0.60 |
| AKT | co_discussed | protein | 0.50 |
| NDUFA9 | co_discussed | gene | 0.50 |
| PARKIN | co_discussed | gene | 0.50 |
| PI3K | co_discussed | protein | 0.50 |
| SLC6A3 | co_discussed | gene | 0.50 |
| SNCA | co_discussed | gene | 0.50 |
| TUBB | co_discussed | gene | 0.50 |
| TUBB3 | co_discussed | gene | 0.50 |
| SNCA | interacts_with | gene | 0.50 |
| TUBB | co_expressed_with | gene | 0.50 |
| TUBB3 | co_expressed_with | gene | 0.50 |
| ALZHEIMER | co_discussed | gene | 0.50 |
| GENES | co_discussed | gene | 0.50 |
| HUNTINGTON | co_discussed | gene | 0.50 |
| PARKINSON | co_discussed | gene | 0.50 |
| PRION | co_discussed | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||