gene

TUBB4B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TUBB4B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

87Connections
0Hypotheses
0Analyses
46Outgoing
41Incoming

Summary

TUBB4B is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, implicated in. Associated with Alzheimer, Huntington, Ms. Connected to 39 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolTUBB4B
Full NameTubulin Beta 4B Class IIa
AliasesPage for TUBB4B
Chromosome9q34.3
FunctionTUBB4B encodes beta-tubulin isotype 4B, a structural component of microtubules.
Primary Expressionphotoreceptor cells and retinal ganglion cells
Molecular Weight50 kDa
Amino Acids444 aa
PathwaysAkt, Cell Cycle, Pi3K
UniProt IDP68371
NCBI Gene ID10383
Ensembl IDENSG00000144410
OMIM191307
GeneCardsTUBB4B
Human Protein AtlasTUBB4B
Associated DiseasesAlzheimer, Huntington, Parkinson, Parkinson'S Disease, Prion
InteractionsNDUFA9, TUBB3, SLC6A3, TUBB, Prion, ALZHEIMER
KG Connections87 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: TUBB4B — AlphaFold P68371 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

TUBB4B - Tubulin Beta 4B Class IIa

gene · 1002 words

TUBB — Tubulin Beta Class I

gene · 3103 words

TUBB2A — Tubulin Beta 2A Class IIa

gene · 2613 words

TUBB2B — Tubulin Beta 2B Class IIb

gene · 2334 words

TUBB1 — Tubulin Beta 1

gene · 1634 words

Expand Microtubules content

entity · 1565 words

Pathway Diagram

graph TD
    TUBB4B["<b>TUBB4B</b>"]
    Alzheimer{"Alzheimer"}
    TUBB4B -->|"associated with"| Alzheimer
    Ms{"Ms"}
    TUBB4B -->|"regulates"| Ms
    Parkinson{"Parkinson"}
    TUBB4B -->|"regulates"| Parkinson
    Huntington{"Huntington"}
    TUBB4B -->|"associated with"| Huntington
    TUBB4B -->|"associated with"| Parkinson
    Prion_Disease{"Prion Disease"}
    TUBB4B -->|"associated with"| Prion_Disease
    NDUFA9["NDUFA9"]
    TUBB4B -->|"associated with"| NDUFA9
    Pi3K(["Pi3K"])
    TUBB4B -->|"regulates"| Pi3K
    Akt(["Akt"])
    TUBB4B -->|"regulates"| Akt
    AKT["AKT"]
    TUBB4B -->|"regulates"| AKT
    SNCA["SNCA"]
    TUBB4B -->|"associated with"| SNCA
    TUBB3["TUBB3"]
    TUBB4B -->|"associated with"| TUBB3
    TUBB["TUBB"]
    TUBB -->|"associated with"| TUBB4B
    SNCA -->|"associated with"| TUBB4B
    TUBB3 -->|"associated with"| TUBB4B
    SLC6A3["SLC6A3"]
    SLC6A3 -->|"associated with"| TUBB4B
    NDUFA9 -->|"associated with"| TUBB4B
    PI3K["PI3K"]
    PI3K -->|"regulates"| TUBB4B
    GENES["GENES"]
    GENES -->|"associated with"| TUBB4B
    AKT -->|"associated with"| TUBB4B
    PI3K -->|"associated with"| TUBB4B
    AKT -->|"regulates"| TUBB4B
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| TUBB4B
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"regulates"| TUBB4B
    style TUBB4B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (46)

TargetRelationTypeStr
Parkinson's Diseaseassociated_withdisease0.80
Parkinson'S Diseaseassociated_withdisease0.80
Alzheimerassociated_withdisease0.65
Msregulatesdisease0.65
Parkinsonregulatesdisease0.65

Incoming (41)

SourceRelationTypeStr
TUBBassociated_withgene0.60
SNCAassociated_withgene0.60
TUBB3associated_withgene0.60
SLC6A3associated_withgene0.60
NDUFA9associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found