gene

TUBB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TUBB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

115Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

TUBB encodes beta-1-tubulin, a fundamental component of microtubules essential for neuronal architecture, axonal transport, and synaptic function. Implicated in Alzheimer's disease, Parkinson's disease, and neurodevelopmental disorders.

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🧬 Gene Info

Gene Symbol	TUBB
Full Name	Tubulin Beta Class I
Chromosome	6p21.33
Molecular Weight	50 kDa
Amino Acids	450 aa
Pathways	Akt, Cell Cycle, Pi3K
UniProt ID	P07437
NCBI Gene ID	203523
Ensembl ID	ENSG00000101162
OMIM	191130
GeneCards	TUBB
Human Protein Atlas	TUBB
Gene Name	Tubulin Beta Class I
Alternative Names	β1-tubulin, TUBB1
Modification	Site
Associated Diseases	Alzheimer, Alzheimer'S Disease, Huntington, Neurodegeneration, Neurodegenerative Disorders, Parkinson
Interactions	TUBB3, TUBB4B, Prion, ALZHEIMER, HUNTINGTON, SNCA
KG Connections	115 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TUBB — AlphaFold P07437 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (16)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TUBB["<b>TUBB</b>"]
    Neurodegenerative_Disorders{"Neurodegenerative Disorders"}
    TUBB -->|"associated with"| Neurodegenerative_Disorders
    Alzheimer{"Alzheimer"}
    TUBB -->|"associated with"| Alzheimer
    Ms{"Ms"}
    TUBB -->|"regulates"| Ms
    Parkinson{"Parkinson"}
    TUBB -->|"regulates"| Parkinson
    Huntington{"Huntington"}
    TUBB -->|"associated with"| Huntington
    TUBB -->|"associated with"| Parkinson
    Prion_Disease{"Prion Disease"}
    TUBB -->|"associated with"| Prion_Disease
    SNCA["SNCA"]
    TUBB -->|"associated with"| SNCA
    TUBB3["TUBB3"]
    TUBB -->|"associated with"| TUBB3
    SLC6A3["SLC6A3"]
    TUBB -->|"associated with"| SLC6A3
    TUBB4B["TUBB4B"]
    TUBB -->|"associated with"| TUBB4B
    NDUFA9["NDUFA9"]
    TUBB -->|"associated with"| NDUFA9
    NDUFA9 -->|"associated with"| TUBB
    AKT["AKT"]
    AKT -->|"associated with"| TUBB
    PI3K["PI3K"]
    PI3K -->|"associated with"| TUBB
    SLC6A3 -->|"associated with"| TUBB
    PI3K -->|"regulates"| TUBB
    AKT -->|"regulates"| TUBB
    SNCA -->|"associated with"| TUBB
    GENES["GENES"]
    GENES -->|"associated with"| TUBB
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| TUBB
    TUBB3 -->|"associated with"| TUBB
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"regulates"| TUBB
    PARKINSON["PARKINSON"]
    PARKINSON -->|"regulates"| TUBB
    style TUBB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (61)

Target	Relation	Type	Str
Parkinson'S Disease	associated_with	disease	0.95
Neurodegenerative Disorders	associated_with	disease	0.85
Neurodegenerative Disorders	biomarker_for	disease	0.85
Parkinson's Disease	biomarker_for	disease	0.85
Alzheimer'S Disease	associated_with	disease	0.85
Neurodegeneration	associated_with	disease	0.82
Parkinson's Disease	associated_with	disease	0.80
Alzheimer	associated_with	disease	0.65
Ms	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Huntington	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Prion Disease	associated_with	disease	0.65
Prion	associated_with	disease	0.65
SNCA	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
TUBB4B	associated_with	gene	0.60
NDUFA9	associated_with	gene	0.60
PI3K	regulates	gene	0.60
AKT	regulates	gene	0.60
TUBB3	regulates	entity	0.60
TUBB4B	regulates	entity	0.60
Rb	regulates	protein	0.60
TUBB3	interacts_with	gene	0.60
TUBB4B	interacts_with	gene	0.60
neurodegeneration	interacts_with	disease	0.60
cancer	activates	disease	0.60
Pi3K	regulates	pathway	0.60
Akt	regulates	pathway	0.60
GENES	associated_with	gene	0.60
Akt	associated_with	pathway	0.60
Cell Cycle	associated_with	pathway	0.60
Pi3K	associated_with	pathway	0.60
SYNAPSE	regulates	gene	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
HUNTINGTON	associated_with	gene	0.60
Cell Cycle	regulates	pathway	0.60
PARKINSON	regulates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
Dopaminergic	regulates	cell_type	0.60
Α-Synuclein	associated_with	protein	0.60
Huntington's disease	interacts_with	disease	0.60
Alzheimer's disease	interacts_with	disease	0.60
autophagy pathway	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
TUBB3	co_discussed	gene	0.50

Incoming (54)

Source	Relation	Type	Str
NDUFA9	associated_with	gene	0.60
AKT	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
PI3K	regulates	gene	0.60
AKT	regulates	gene	0.60
SNCA	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
NDUFA9	regulates	entity	0.60
SLC6A3	regulates	entity	0.60
SNCA	regulates	entity	0.60
AIFM1	activates	gene	0.60
ATP5A1	activates	gene	0.60
CALCOCO2	activates	gene	0.60
HSP60	activates	gene	0.60
HSPD1	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
NDP52	activates	gene	0.60
OPTN	activates	gene	0.60
PARL	activates	gene	0.60
PHB2	activates	gene	0.60
PINK1	activates	gene	0.60
PRKN	activates	gene	0.60
PTEN	activates	gene	0.60
TOMM20	activates	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
HUNTINGTON	associated_with	gene	0.60
COX2	activates	gene	0.60
LC3B	activates	gene	0.60
PGAM5	activates	gene	0.60
ATP	activates	gene	0.60
AKT	co_discussed	protein	0.50
NDUFA9	co_discussed	gene	0.50
PARKIN	co_discussed	gene	0.50
PI3K	co_discussed	protein	0.50
SLC6A3	co_discussed	gene	0.50
SNCA	co_discussed	gene	0.50
SNCA	interacts_with	gene	0.50
TUBB4B	interacts_with	gene	0.50
NDUFA9	interacts_with	gene	0.50
TUBB3	interacts_with	gene	0.50
SLC6A3	interacts_with	gene	0.50
SLC6A3	co_expressed_with	gene	0.50
SNCA	co_expressed_with	gene	0.50
ALZHEIMER	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TUBB

Understanding Entity Pages

Summary

Wiki Pages (16)

TUBB — Tubulin Beta Class I

TUBB2A — Tubulin Beta 2A Class IIa

TUBB2B — Tubulin Beta 2B Class IIb

KIF14 Gene

TUBA1A — Tubulin Alpha 1A

Protein-Protein Interactions in Neurodegeneration

TUBB1 — Tubulin Beta 1

GPER (G-Protein Coupled Estrogen Receptor) Neurons

TUBA1A Protein

MAP7 - Microtubule Associated Protein 7

NDUFA9 Gene

Tubulin Protein

Peripheral Sensory Neurons in Chemotherapy-Induced Neuropathy

Tubulin Beta-4A Protein