Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Type 2 Diabetes: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Associated Genes | MTORC1, CANCER, MTOR, INSULIN RESISTANCE, DIABETES MELLITUS, CLOCK, GENES, AUTOPHAGY |
| Therapeutic Agents | Tirzepatide, Exendin-4, Metformin, Gliflozins, METFORMIN, Postbiotics |
| KG Connections | 742 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Type_2_Diabetes["<b>Type 2 Diabetes</b>"]
Insulin_Resistance{"Insulin Resistance"}
Type_2_Diabetes -->|"associated_with"| Insulin_Resistance
Diabetes{"Diabetes"}
Type_2_Diabetes -->|"therapeutic_target"| Diabetes
Oxidative_Stress["Oxidative Stress"]
Type_2_Diabetes -->|"activates"| Oxidative_Stress
Als{"Als"}
Als -->|"regulates"| Type_2_Diabetes
INSULIN_RESISTANCE(["INSULIN RESISTANCE"])
INSULIN_RESISTANCE -->|"associated_with"| Type_2_Diabetes
style Type_2_Diabetes fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Insulin Resistance | associated_with | disease | 1.00 |
| Diabetes | therapeutic_target | disease | 1.00 |
| Diabetes | associated_with | disease | 1.00 |
| Insulin Resistance | therapeutic_target | disease | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Insulin Resistance | activates | disease | 0.95 |
| Heart Failure | risk_factor_for | disease | 0.90 |
| Chronic Kidney Disease | risk_factor_for | disease | 0.90 |
| INFLAMMATION | causes | process | 0.90 |
| Lipid Metabolism | therapeutic_target | pathway | 0.90 |
| ALZHEIMER'S DISEASE | risk_factor_for | disease | 0.88 |
| Diabetic Complications | causes | disease | 0.85 |
| Insulin Resistance | regulates | disease | 0.85 |
| Insulin Resistance | contributes_to | disease | 0.85 |
| Diabetes | activates | disease | 0.85 |
| Peripheral Low-Grade Inflammation | causes | process | 0.85 |
| BMAL1 | downregulates | gene | 0.85 |
| NEUROINFLAMMATION | causes | process | 0.85 |
| Alzheimer's Disease | risk_factor_for | disease | 0.80 |
| Oxidative Stress | therapeutic_target | pathway | 0.80 |
| Cholesterol | activates | pathway | 0.80 |
| Mitophagy | activates | pathway | 0.80 |
| Microrna | regulates | pathway | 0.80 |
| Mtor | regulates | pathway | 0.70 |
| Autophagy | inhibits | pathway | 0.70 |
| Lipid Metabolism | inhibits | pathway | 0.70 |
| Autophagy | contributes_to | pathway | 0.70 |
| Insulin Signaling | contributes_to | pathway | 0.70 |
| Mapk | therapeutic_target | pathway | 0.70 |
| Apoptosis | protects_against | pathway | 0.70 |
| Nf-Κb | inhibits | pathway | 0.70 |
| Apoptosis | activates | pathway | 0.70 |
| Oxidative Stress | causes | pathway | 0.70 |
| Microbiota | associated_with | pathway | 0.70 |
| Autophagy | activates | pathway | 0.70 |
| Autophagy | therapeutic_target | pathway | 0.70 |
| Apoptosis | therapeutic_target | pathway | 0.70 |
| Differentiation | regulates | pathway | 0.70 |
| Lipid Metabolism | regulates | pathway | 0.70 |
| Microrna | biomarker_for | pathway | 0.70 |
| Oxidative Stress | regulates | pathway | 0.70 |
| Cholesterol | associated_with | pathway | 0.70 |
| Epigenetic | treats | pathway | 0.70 |
| Dysbiosis | therapeutic_target | pathway | 0.70 |
| Epigenetic | associated_with | pathway | 0.70 |
| Diabetes | causes | disease | 0.65 |
| Diabetes | implicated_in | disease | 0.65 |
| Insulin Resistance | causes | disease | 0.65 |
| Diabetes | regulates | disease | 0.65 |
| Diabetes | interacts_with | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Diabetes | regulates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| INSULIN RESISTANCE | associated_with | gene | 1.00 |
| DIABETES MELLITUS | associated_with | gene | 1.00 |
| Diabetes | contributes_to | disease | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Diabetes | inhibits | disease | 1.00 |
| DIABETES MELLITUS | therapeutic_target | gene | 1.00 |
| INSULIN RESISTANCE | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| Diabetes | therapeutic_target | disease | 1.00 |
| Diabetes | associated_with | disease | 1.00 |
| Obesity | associated_with | disease | 1.00 |
| DIABETES MELLITUS | activates | gene | 1.00 |
| Diabetes | activates | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| INSULIN RESISTANCE | therapeutic_target | gene | 1.00 |
| Als | treats | disease | 1.00 |
| ROS | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| Plasma Proteins | associated_with | biomarker | 0.95 |
| Obesity | regulates | disease | 0.95 |
| INFLAMMATION | contributes_to | gene | 0.95 |
| DIABETES MELLITUS | contributes_to | gene | 0.95 |
| INFLAMMATION | inhibits | gene | 0.95 |
| Inflammation | activates | disease | 0.95 |
| Obesity | therapeutic_target | disease | 0.95 |
| Cancer | associated_with | disease | 0.95 |
| Cardiovascular | associated_with | disease | 0.95 |
| Metabolic Syndrome | associated_with | disease | 0.95 |
| INSULIN RESISTANCE | regulates | gene | 0.95 |
| AGING | associated_with | gene | 0.95 |
| INSULIN RESISTANCE | contributes_to | gene | 0.95 |
| Inflammation | regulates | disease | 0.95 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 0.95 |
| ALZHEIMER'S DISEASE | activates | gene | 0.95 |
| GENES | associated_with | gene | 0.95 |
| Tirzepatide | treats | drug | 0.95 |
| Exendin-4 | treats | drug | 0.95 |
| Gliflozins | treats | drug | 0.95 |
| Metformin | treats | drug | 0.90 |
| METFORMIN | treats | drug | 0.90 |
| glycated haemoglobin | biomarker_for | phenotype | 0.90 |
| Circadian Disruption | risk_factor_for | process | 0.85 |
| Obesity | risk_factor_for | phenotype | 0.85 |
| AGING | regulates | gene | 0.85 |
| Inflammation | contributes_to | disease | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||