Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about apoc3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | APOC3 |
| Full Name | Apolipoprotein C-III |
| Aliases | ApoC-III |
| Chromosome | 11q23.3 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | Hepatocytes in the liver (highest expression) |
| Molecular Weight | 8.8 kDa |
| Amino Acids | 79 aa |
| Pathways | Cholesterol |
| NCBI Gene ID | 345 |
| Ensembl ID | ENSG00000110245 |
| GeneCards | APOC3 |
| Human Protein Atlas | APOC3 |
| Associated Diseases | Als, Aging, Cardiovascular, Atherosclerosis, neurodegeneration |
| Interactions | LRP1, CYP46A1, LDLR, LRP8, APOE, ABCA1 |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
APOC3["APOC3"]
APOC3 -->|"inhibits"| Atherosclerosis["Atherosclerosis"]
APOC3 -->|"regulates"| Alzheimer["Alzheimer"]
APOC3 -->|"regulates"| Als["Als"]
APOC3 -->|"transports"| ALS["ALS"]
CH25H["CH25H"] -->|"activates"| APOC3
LRP8["LRP8"] -->|"activates"| APOC3
APOA1["APOA1"] -->|"activates"| APOC3
MAPT["MAPT"] -->|"regulates"| APOC3
LRP1["LRP1"] -->|"activates"| APOC3
LIPA["LIPA"] -->|"regulates"| APOC3
ALZHEIMER["ALZHEIMER"] -->|"regulates"| APOC3
APP["APP"] -->|"regulates"| APOC3Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||