concept

REMYELINATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about REMYELINATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

124Connections

1Hypotheses

0Analyses

26Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	REMYELINATION
Key Genes/Proteins	PI3K, TREM2, NRF2
Related Diseases	DEMYELINATION, AUTOPHAGY, NEURODEGENERATION, PYROPTOSIS
Related Pathways	WNT SIGNALING
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    REMYELINATION["REMYELINATION"]
    style REMYELINATION fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    REMYELINATION -.->|"protects against"| Multiple_Sclerosis_Progression(Multiple Sclerosis Progression)
    REMYELINATION -->|"causes"| STING([STING])
    REMYELINATION -->|"impairs"| WHITE_MATTER((WHITE MATTER))
    OSTEOCALCIN([OSTEOCALCIN]) -->|"involved_in"| REMYELINATION
    trehalose{"trehalose"} -->|"activates"| REMYELINATION
    DEMYELINATION["DEMYELINATION"] -->|"interacts"| REMYELINATION
    MYELINATION["MYELINATION"] -->|"interacts"| REMYELINATION
    NEURODEGENERATION["NEURODEGENERATION"] -->|"contributes to"| REMYELINATION
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"] -->|"promotes"| REMYELINATION
    APOPTOSIS["APOPTOSIS"] -.->|"inhibits"| REMYELINATION
    INFLAMMATION["INFLAMMATION"] -.->|"inhibits"| REMYELINATION

Outgoing (29)

Target	Relation	Type	Str
NEURONS	interacts_with	cell_type	0.65
NEURONS	protects_against	cell_type	0.65
SPINAL CORD	regulates	brain_region	0.65
PI3K	activates	gene	0.65
AUTOPHAGY	regulates	phenotype	0.65
TREM2	causes	gene	0.65
OLIGODENDROCYTE	causes	cell_type	0.65
DEMYELINATION	treats	phenotype	0.65
SPINAL CORD	activates	brain_region	0.65
WNT SIGNALING	regulates	pathway	0.65
NEURODEGENERATION	inhibits	disease	0.65
NRF2	stabilizes	gene	0.60
WHITE MATTER	activates	brain_region	0.50
BLOOD-BRAIN BARRIER	activates	process	0.50
MTOR PATHWAY	regulates	pathway	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
MTOR PATHWAY	associated_with	pathway	0.45
LUTEOLIN	associated_with	drug	0.45
SPINAL CORD	associated_with	brain_region	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
WNT SIGNALING	associated_with	pathway	0.45
TRAUMATIC BRAIN INJURY	implicated_in	disease	0.35
WHITE MATTER	associated_with	brain_region	0.35
WHITE MATTER	repairs	brain_region	0.35
STEM CELLS	activates	cell_type	0.35
TNF	activates	gene	0.30

Incoming (95)

Source	Relation	Type	Str
DEMYELINATION	exacerbates	phenotype	0.70
NRF2	regulates	gene	0.65
OLIGODENDROCYTE	regulates	cell_type	0.65
PYROPTOSIS	activates	phenotype	0.65
TREM2	activates	gene	0.65
APOPTOSIS	activates	phenotype	0.65
AUTOPHAGY	stabilizes	phenotype	0.60
OLIGODENDROCYTE	targets	cell_type	0.60
OLIGODENDROCYTE	implicated_in	cell_type	0.55
MTOR PATHWAY	implicated_in	pathway	0.55
TREM2	implicated_in	gene	0.55
MYELINATION	co_discussed	entity	0.50
OLIGODENDROCYTE	co_discussed	entity	0.50
DEMYELINATION	activates	process	0.50
AUTOPHAGY	activates	process	0.50
NEURONS	regulates	cell_type	0.50
TBI	involved_in	disease	0.50
OLIGODENDROCYTE	activates	cell_type	0.50
OLIGODENDROCYTE	associated_with	cell_type	0.50
INFLAMMATION	causes	process	0.50
INFLAMMATION	associated_with	process	0.50
Oligodendrocyte	associated_with	cell_type	0.50
Myelination	associated_with	pathway	0.50
MYELIN	associated_with	concept	0.50
inflammation	inhibits	pathway	0.50
disease	inhibits	disease	0.50
Neurodegeneration	associated_with	disease	0.50
inflammation	associated_with	pathway	0.50
microglia	causes	cell_type	0.50
aging	causes	phenotype	0.50
White Matter	causes	process	0.50
Neurodegeneration	interacts_with	disease	0.50
Neurodegeneration	regulates	disease	0.50
apoptosis	inhibits	process	0.50
C-JUN	activates	protein	0.50
Neuroprotection	inhibits	process	0.50
microglia	activates	cell_type	0.50
Myelination	activates	pathway	0.50
MYELIN	activates	concept	0.50
White Matter	activates	process	0.50
CCL5	associated_with	gene	0.50
Neuron	associated_with	cell_type	0.50
AXON	associated_with	concept	0.50
Oligodendrocyte	activates	cell_type	0.50
mTOR	regulates	entity	0.50
White Matter	inhibits	process	0.50
Autophagy	activates	process	0.50
SPI1	activates	gene	0.50
Macrophage	activates	cell_type	0.50
MYELIN	interacts_with	concept	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Oligodendrocyte Remyelination Enhancement	0.474	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (16)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
cGAMP Enhances Microglial/Macrophage Phagocytosis in Ischemic Stroke Via Activat [PMID:41495583]	["Li Xinyu", "Ding Huamin", "Qian Shuyu"	Inflammation	2026
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213]	Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei	Neuron	2026
Role of TREM2 in neuroinflammation. [PMID:41213496]	Abdulkhaliq AA, Alasiri G, Almoghrabi Y,	Exp Neurol	2026
Fusion of Tumor Cells with Lipid-Associated Macrophages Drives Metastatic Progre [PMID:41342370]	Cheng Y, Huang G, Liu X, Wu C, Lian J et	Cancer Res	2026
Targeting senescent EGR1(+) B cells enhances immunotherapy efficacy in esophagea [PMID:41483805]	Zhou P, Zhang Y, Zhang H, Zhao P, Guo Y	Cell Rep Med	2026
Synergistic potential of TREM2 agonists and exercise training in Alzheimer's dis [PMID:41494649]	Zhang J, St Pierre Schneider B, Muguerza	Am J Physiol Endocrinol Metab	2026
Diankuang Mengxing Decoction exerts neuroprotective effects in post-stroke depre [PMID:41534750]	Yang X, Zhao Y, Liu W, Feng J, Wu X et a	J Ethnopharmacol	2026
Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952]	Li X, Tang X, Zeng J, Duan L, Hou Z et a	Cell	2026
TREM2 expression level is critical for microglial state, metabolic capacity and [PMID:41580393]	Feiten AF, Dahm K, Schlepckow K, van Len	Nat Commun	2026
TREM2 and microglial immunity in Alzheimer's disease: mechanisms, genetics, and [PMID:41789102]	Wang T, Liu X, Wang X, Hua F, Yan L	Front Immunol	2026
TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604]	Yang HC, Deng YS, Zhang J, Zhang T, Song	J Alzheimers Dis	2026
TREM2 in neurodegeneration and diseases. [PMID:41792456]	["Abdulkhaliq A", "Alasiri G", "Kim B",	Molecular psychiatry	2026
Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721]	Aranda-Abreu GE, Rojas-Durán F, Hernánde	Neurology international	2026
Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842]	Alhusaini M, Mussa BM, Ilce BY, Alhaj H,	Frontiers in aging neuroscienc	2026
Viral and non-viral cellular therapies for neurodegeneration. [PMID:41585268]	["Srivastav Jyotsna", "Sharma Sachin"]	Frontiers in medicine	2025
Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy. [PMID:20301376]	Adam MP, Bick S, Mirzaa GM, Pagon RA, Wa		1993

REMYELINATION

Understanding Entity Pages

Wiki Pages (20)

Progressive Supranuclear Palsy (PSP)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Corticobasal Degeneration (CBD)

NRF2 Oxidative Stress Pathway

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub

Oligodendrocytes

TREM2 Microglial Signaling Pathway in Neurodegeneration

Vitamin D Signaling Pathway in Neurodegeneration

rankings

Glia-Neuron Crosstalk in Alzheimer's Disease

Beta-Secretase (BACE1) Protein

Microglial Senescence Pathway in Neurodegeneration

University of North Carolina at Chapel Hill

Multiple Sclerosis (MS)

Cleveland Clinic Lerner Research Institute

FGF10 — Fibroblast Growth Factor 10

UBE2L3 — Ubiquitin-Conjugating Enzyme E2 L3