concept

AREG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AREG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

50Connections

0Hypotheses

0Analyses

35Outgoing

15Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	AREG
Key Genes/Proteins	BMAL1-HIF2A complex, BMAL1, CANCER, HIF2A
Related Diseases	myocardial injury, Cancer, Tumor, Infection, Inflammation
Related Pathways	PI3K/Akt/GSK-3β pathway, Circadian Rhythm

Pathway Diagram

graph TD
    AREG["AREG"]
    AREG -->|"regulates"| myocardial_injury["myocardial injury"]
    AREG -->|"activates"| PI3K_Akt_GSK_3__pathway["PI3K/Akt/GSK-3beta pathway"]
    AREG -->|"regulates"| Cancer["Cancer"]
    AREG -->|"implicated in"| Tumor["Tumor"]
    AREG -->|"contributes to"| Infection["Infection"]
    AREG -->|"contributes to"| Inflammation["Inflammation"]
    AREG -->|"regulates"| Ms["Ms"]
    AREG -->|"regulates"| Cardiac["Cardiac"]
    BMAL1_HIF2A_complex["BMAL1-HIF2A complex"] -->|"activates"| AREG
    BMAL1["BMAL1"] -->|"activates"| AREG
    DNA["DNA"] -->|"regulates"| AREG
    BANG["BANG"] -->|"regulates"| AREG
    CYTOKINES["CYTOKINES"] -->|"regulates"| AREG
    INFLAMMATION["INFLAMMATION"] -->|"contributes to"| AREG
    EGF["EGF"] -->|"regulates"| AREG

Outgoing (35)

Target	Relation	Type	Str
myocardial injury	regulates	phenotype	0.80
PI3K/Akt/GSK-3β pathway	activates	pathway	0.70
Cancer	regulates	disease	0.65
Tumor	implicated_in	disease	0.65
Infection	contributes_to	disease	0.65
Inflammation	contributes_to	disease	0.65
Ms	regulates	disease	0.65
Cardiac	regulates	disease	0.65
Pain	regulates	disease	0.65
BMAL1	therapeutic_target	gene	0.60
CANCER	regulates	gene	0.60
Circadian Rhythm	regulates	pathway	0.60
HIF2A	regulates	gene	0.60
CD4	regulates	gene	0.60
DNA	regulates	gene	0.60
HIF2A	therapeutic_target	gene	0.60
AND	regulates	gene	0.60
BANG	regulates	gene	0.60
BMAL1	regulates	gene	0.60
Mapk	associated_with	pathway	0.60
PIK3R1	associated_with	gene	0.60
MAPK	associated_with	gene	0.60
ANGPT1	associated_with	gene	0.60
AND	interacts_with	gene	0.60
HIF	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
Rb	regulates	protein	0.60
App	regulates	protein	0.60
Hif-1	associated_with	protein	0.60
Akt	associated_with	protein	0.60
App	associated_with	protein	0.60
BMAL1	targets	gene	0.60
HIF2A	targets	gene	0.60
BMAL1	associated_with	gene	0.60
HIF2A	associated_with	gene	0.60

Incoming (15)

Source	Relation	Type	Str
BMAL1-HIF2A complex	activates	protein	0.90
BMAL1	activates	gene	0.70
DNA	regulates	gene	0.60
BMAL1	regulates	gene	0.60
BANG	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
INFLAMMATION	contributes_to	gene	0.60
EGF	regulates	gene	0.60
BMAL1	therapeutic_target	gene	0.60
ANGPT1	associated_with	gene	0.60
MAPK	associated_with	gene	0.60
PIK3R1	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AKT	associated_with	gene	0.60
HIF2A	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found