concept

LPS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LPS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

56Connections

9Hypotheses

6Analyses

45Outgoing

11Incoming

1Experiments

10Debates

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💡 Concept Info

Name	LPS
Key Genes/Proteins	ACSL4, BAX, BCL2, BDNF, C1Q, GFAP
Related Diseases	Alzheimer's disease, depression, major depressive disorder
Related Pathways	autophagy, MAPK
Linked Hypotheses	9 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

LLPS Modulator Therapy

therapeutic · 1296 words

→

Pathway Diagram

graph TD
    LPS["LPS"]
    LPS -->|"activates"| NF_kappaB["NF-kappaB"]
    LPS -->|"activates"| MAPK["MAPK"]
    LPS -->|"causes"| pulmonary_inflammation["pulmonary inflammation"]
    LPS -->|"causes"| neuroinflammation["neuroinflammation"]
    LPS -->|"causes"| Acute_Lung_Injury["Acute Lung Injury"]
    LPS -->|"activates"| NLRP3_Inflammasome_Activation["NLRP3 Inflammasome Activation"]
    LPS -->|"causes"| Septic_Cardiomyopathy["Septic Cardiomyopathy"]
    LPS -->|"upregulates"| C3["C3"]
    LOXL3["LOXL3"] -->|"modulates"| LPS

Outgoing (45)

Target	Relation	Type	Str
NLRP3 Inflammasome Activation	activates	process	0.90
Septic Cardiomyopathy	causes	disease	0.90
GFAP	activates	protein	0.90
pulmonary inflammation	causes	phenotype	0.90
C3	upregulates	protein	0.90
BBB breakdown	causes	phenotype	0.90
neuroinflammation	causes	phenotype	0.90
MAPK	activates	pathway	0.90
TLR4/NF-κB signaling	activates	pathway	0.90
NF-kappaB	activates	protein	0.90
Tlr4/Nf-Κb Signaling	activates	pathway	0.90
Ferroptosis	associated_with	process	0.85
NLRP3 Inflammasome Activation	associated_with	process	0.85
GFAP	contributes_to	protein	0.80
MTOR	activates	gene	0.80
autophagy	activates	pathway	0.80
BAX	activates	gene	0.75
NLRP3 inflammasome	activates	protein	0.70
microglia	activates	cell_type	0.70
mitophagy	inhibits	process	0.70
Non-Motor Symptoms	associated_with	phenotype	0.70
TLR4	activates	gene	0.70
BDNF	regulates	protein	0.70
Alzheimer's disease	associated_with	disease	0.70
BCL2	inhibits	protein	0.70
PINK1/Parkin	inhibits	protein	0.70
MAP1LC3B	inhibits	protein	0.70
major depressive disorder	causes	disease	0.70
NLRP3	activates	protein	0.70
PI3K	activates	protein	0.70
PINK1	inhibits	protein	0.70
NRF2	activates	gene	0.70
ACSL4	induces	protein	0.70
Parkinson's disease	associated_with	disease	0.70
TLR4	activates	protein	0.70
Microglial priming	causes	process	0.70
microglial priming	activates	mechanism	0.70
TNF	activates	protein	0.70
NEUROINFLAMMATION	activates	pathway	0.64
PRDX1	inhibits	protein	0.64
MACROPHAGES	activates	cell_type	0.64
MMP9	activates	protein	0.64
depression	causes	disease	0.56
PYROPTOSIS	activates	phenotype	0.56
C1Q	activates	protein	0.56

Incoming (11)

Source	Relation	Type	Str
39427196	acutely increased	paper	0.90
37157885	induces	paper	0.90
37157885	causes activation of	paper	0.90
33515352	suppressed	paper	0.90
33515352	suppressed and induced	paper	0.90
33515352	induces	paper	0.90
33515352	suppresses and induces	paper	0.90
39580436	acts as a key relay of	paper	0.90
27143001	activates	paper	0.90
33515352	induced	paper	0.60
LRRK2	interacts_with	gene	0.60

Targeting Hypotheses (9)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TLR4/MyD88/NF-κB Axis Blockade to Interrupt LPS-Mediated Gut	0.703	neurodegeneration	How do gut microbiome-derived metabolite
Leaky Gut LPS Translocation Activates Systemic TLR4/MyD88 Si	0.670	neurodegeneration	How does gut microbiome dysbiosis contri
LPS-primed microglial trained immunity establishes persisten	0.670	neurodegeneration	Synaptic pruning by microglia in neurode
Alpha-synuclein phosphorylation-dominated LLPS hijacks synap	0.657	parkinsons	-
Intestinal Permeability Defects → Systemic LPS Translocation	0.630	neurodegeneration	What are the mechanisms by which gut mic

LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target	0.619	neurodegeneration	Gut-Brain Axis in Parkinson's Disease: M
TDP-43 LLPS and proteostasis dysregulation in ALS/FTD	0.600	neurodegeneration	Test
Liquid-Liquid Phase Separation (LLPS) Saturation Partitionin	0.461	neurodegeneration	What determines the spatial organization
plasma LPS-binding protein separates causal from compensator	0.346	neurodegeneration	How does gut microbiome dysbiosis contri

Mentioning Analyses (6)

Scientific analyses that reference this entity

Gut-Brain Axis in Parkinson's Disease: Molecular Mechanisms, Neuroinflammation,

neurodegeneration | 2026-04-26 | 4 hypotheses Top: 0.630

How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synucle

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.703

What determines the GPX4/ACSL4 balance that switches microglia from protective t

immunology | 2026-04-15 | 0 hypotheses

How does engineered C. butyricum cross the blood-brain barrier to directly bind

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.699

How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liq

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.730

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism and inter	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,500,000

Related Papers (15)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Chrysophanol Attenuates Cognitive Impairment, Neuroinflammation, and Oxidative S [PMID:40728692]	Khan JZ, Zainab SR, Alattar A	Neurochem Res	2025
Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and [PMID:38552431]	Wang W, Wang Y, Wang F, Xie G, Liu S, Li	Phytomedicine : international	2024
Qingda granule alleviates cerebral ischemia/reperfusion injury by inhibiting TLR [PMID:38184025]	Unknown	Journal of ethnopharmacology	2024
Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and [PMID:38552431]	Wang W, Wang Y, Wang F, Xie G, Liu S, Li	Phytomedicine : international	2024
Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting n [PMID:36601662]	["Zhang Di", "Jing Bei", "Chen Zhen-Ni",	CNS neuroscience & therapeutic	2023
Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation [PMID:37435081]	Park, Hwang, Lee, Jang, Jeong et al.	Frontiers in immunology	2023
Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation [PMID:37435081]	Unknown	Frontiers in immunology	2023
Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting n [PMID:36601662]	["Zhang Di", "Jing Bei", "Chen Zhen-Ni",	CNS neuroscience & therapeutic	2023
Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microgl [PMID:37466915]	Sun W, Wang Q, Zhang R, Zhang N	Food & function	2023
NLRP3 inflammasome inhibition and M1-to-M2 microglial polarization shifting via [PMID:37137264]	Ibrahim Weam W; Skalicka-Woźniak K	International immunopharmacolo	2023
Early glycolytic reprogramming controls microglial inflammatory activation. [PMID:34107997]	["Cheng Junjie", "Zhang Rong", "Xu Zhiro	Journal of neuroinflammation	2021
Early glycolytic reprogramming controls microglial inflammatory activation. [PMID:34107997]	["Cheng Junjie", "Zhang Rong", "Xu Zhiro	Journal of neuroinflammation	2021
Microglia clear neuron-released α-synuclein via selective autophagy and prevent [PMID:32170061]	Choi I, Zhang Y, Seegobin SP	Nat Commun	2020
Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction throug [PMID:32622362]	Mondal A, Bose D, Saha P	J Neuroinflammation	2020
RETRACTED: Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammat [PMID:30884890]	["Muhammad T", "Ikram M", "Ullah R", "Re	Nutrients	2019

Debates (10)

Multi-agent debates referencing this entity

Hypothesis debate: SCFA Deficiency Disrupts Microglial Homeostasis and Promotes

closed · Rounds: 4 · Score: 0.60 · 2026-04-26

Hypothesis debate: Vagus Nerve as Anatomical Highway for Prion-Like α-Syn Propag

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

Hypothesis debate: Enteric Nervous System Dysfunction as Self-Reinforcing Pathol

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

Hypothesis debate: LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

What are the key molecular mechanisms by which gut microbiome dysbiosis drives n

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

The study shows that G3BP1 ubiquitination inhibits LLPS in vitro, but the molecu

closed · Rounds: 4 · Score: 0.79 · 2026-04-21

How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synucle

closed · Rounds: 4 · Score: 0.84 · 2026-04-16

While ACSL4-driven ferroptosis was strongly supported, the molecular triggers th

closed · Rounds: 4 · Score: 0.80 · 2026-04-16

The abstract claims C. butyricum-GLP-1 crosses the BBB and binds to GLP-1 recept

closed · Rounds: 4 · Score: 0.95 · 2026-04-15

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning LPS in their description or question text

LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target

Score: 0.619 · neurodegeneration · 2026-04-26

Gut dysbiosis leads to LPS translocation, triggering intestinal and systemic inflammation via TLR4/MyD88/NF-κB signaling

TDP-43 LLPS and proteostasis dysregulation in ALS/FTD

Score: 0.600 · neurodegeneration · 2026-04-29

TDP-43 stress-granule entry and liquid-liquid phase separation may transition from reversible condensates into pathologi

Liquid-Liquid Phase Separation (LLPS) Saturation Partitioning Excludes Autophagy

Score: 0.461 · neurodegeneration · 2026-04-21

## Mechanistic Overview Liquid-Liquid Phase Separation (LLPS) Saturation Partitioning Excludes Autophagy Receptors from

plasma LPS-binding protein separates causal from compensatory states in: How doe

Score: 0.346 · neurodegeneration · 2026-04-26

A longitudinal biomarker panel centered on plasma LPS-binding protein can distinguish harmful mechanisms from protective

LPS

Understanding Entity Pages

Wiki Pages (1)

LLPS Modulator Therapy

Pathway Diagram

Outgoing (45)

Incoming (11)

Targeting Hypotheses (9)

Mentioning Analyses (6)

Gut-Brain Axis in Parkinson's Disease: Molecular Mechanisms, Neuroinflammation,

How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synucle

What determines the GPX4/ACSL4 balance that switches microglia from protective t

How does engineered C. butyricum cross the blood-brain barrier to directly bind

How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liq

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Experiments (1)

Related Papers (15)

Debates (10)

Hypothesis debate: SCFA Deficiency Disrupts Microglial Homeostasis and Promotes

Hypothesis debate: Vagus Nerve as Anatomical Highway for Prion-Like α-Syn Propag

Hypothesis debate: Enteric Nervous System Dysfunction as Self-Reinforcing Pathol

Hypothesis debate: LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target

What are the key molecular mechanisms by which gut microbiome dysbiosis drives n

The study shows that G3BP1 ubiquitination inhibits LLPS in vitro, but the molecu

How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synucle

While ACSL4-driven ferroptosis was strongly supported, the molecular triggers th

The abstract claims C. butyricum-GLP-1 crosses the BBB and binds to GLP-1 recept

What are the mechanisms underlying what are the mechanisms by which gut microbio

Related Research

LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target

TDP-43 LLPS and proteostasis dysregulation in ALS/FTD

Liquid-Liquid Phase Separation (LLPS) Saturation Partitioning Excludes Autophagy

plasma LPS-binding protein separates causal from compensatory states in: How doe