concept

LPS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LPS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections

0Hypotheses

1Analyses

30Outgoing

0Incoming

1Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	LPS
Key Genes/Proteins	NF-kappaB, GFAP, MTOR, BAX, TNF, TLR4
Related Diseases	pulmonary inflammation, neuroinflammation, Alzheimer's disease
Related Pathways	MAPK, autophagy

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LPS["LPS"]
    LPS -->|"activates"| NF_kappaB["NF-kappaB"]
    LPS -->|"activates"| MAPK["MAPK"]
    LPS -->|"causes"| pulmonary_inflammation["pulmonary inflammation"]
    LPS -->|"causes"| neuroinflammation["neuroinflammation"]
    LPS -->|"causes"| Acute_Lung_Injury["Acute Lung Injury"]
    LPS -->|"activates"| NLRP3_Inflammasome_Activation["NLRP3 Inflammasome Activation"]
    LPS -->|"causes"| Septic_Cardiomyopathy["Septic Cardiomyopathy"]
    LPS -->|"upregulates"| C3["C3"]
    LOXL3["LOXL3"] -->|"modulates"| LPS

Outgoing (35)

Target	Relation	Type	Str
NF-kappaB	activates	protein	0.90
MAPK	activates	pathway	0.90
pulmonary inflammation	causes	phenotype	0.90
neuroinflammation	causes	phenotype	0.90
GFAP	activates	protein	0.90
autophagy	activates	pathway	0.80
MTOR	activates	gene	0.80
GFAP	contributes_to	protein	0.80
BAX	activates	gene	0.75
TNF	activates	protein	0.70
TLR4	activates	protein	0.70
Alzheimer's disease	associated_with	disease	0.70
BCL2	inhibits	protein	0.70
mitophagy	inhibits	process	0.70
NLRP3 inflammasome	activates	protein	0.70
MAP1LC3B	inhibits	protein	0.70
major depressive disorder	causes	disease	0.70
NLRP3	activates	protein	0.70
PI3K	activates	protein	0.70
BDNF	regulates	protein	0.70
PINK1	inhibits	protein	0.70
PINK1/Parkin	inhibits	protein	0.70
microglia	activates	cell_type	0.70
PRDX1	inhibits	protein	0.64
MACROPHAGES	activates	cell_type	0.64
NEUROINFLAMMATION	activates	pathway	0.64
MMP9	activates	protein	0.64
PYROPTOSIS	activates	phenotype	0.56
C1Q	activates	protein	0.56
depression	causes	disease	0.56

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liq

neurodegeneration | 2026-04-07 | 0 hypotheses

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism and inter	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,500,000

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LPS

Understanding Entity Pages

Wiki Pages (20)

neuroinflammation

Microglial Cells — Cell Type Hierarchy

TREM2 Microglial Signaling Pathway in Neurodegeneration

Vitamin D Signaling Pathway in Neurodegeneration

nlrc5-protein

dimethyl-fumarate-nrf2-ad-nct06850597

Infectious Triggers in Alzheimer's Disease

Epigenetic Alterations in Alzheimer's Disease

Cerebrospinal Fluid (CSF) Biomarkers Overview

Histamine

creatine-supplementation-neurodegeneration

Gut-Brain Axis in Neurodegeneration

Motor Neuron Disease (MND)

NF-kB Signaling Pathway in Neurodegeneration

Transcriptional Regulation in Neurodegeneration

NF-κB Signaling Pathway in Neurodegeneration

Necroptotic Neurons

Psychobiotic Therapy for Neurodegenerative Diseases

Neuroinflammation Across AD, PD, ALS, FTD, and HD

TREM2→Microglial Dysfunction→Alzheimer's Disease Causal Chain