Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about atg101: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ATG101 |
| Chromosome | 14q24.2 |
| Function | Complex stabilization: ATG101 binds to both ULK1 and ATG13, preventing their degradation |
| Molecular Weight | 200 kDa |
| Amino Acids | 271 aa |
| UniProt ID | Q9Y4P1 |
| NCBI Gene ID | 84888 |
| Ensembl ID | ENSG00000160072 |
| OMIM | 618328 |
| GeneCards | ATG101 |
| Human Protein Atlas | ATG101 |
| Associated Diseases | neurodegeneration |
| Interactions | ATG13, ULK1, C9ORF72, RB1CC1 |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ATG101["ATG101"]
ATG101 -->|"interacts"| ULK1["ULK1"]
ATG101 -->|"interacts"| Autophagy["Autophagy"]
ATG101 -->|"interacts"| Parkinson["Parkinson"]
ATG101 -->|"activates"| Als["Als"]
ATG101 -->|"inhibits"| Dementia["Dementia"]
ATG101 -->|"inhibits"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
ATG101 -->|"inhibits"| Frontotemporal_Dementia["Frontotemporal Dementia"]
ATG["ATG"] -->|"component_of"| ATG101
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"interacts"| ATG101
ATG14L["ATG14L"] -->|"activates"| ATG101
ATG13["ATG13"] -->|"interacts"| ATG101
ZDHHC13["ZDHHC13"] -->|"activates"| ATG101
AUTOPHAGY["AUTOPHAGY"] -->|"interacts"| ATG101
LYSOSOME["LYSOSOME"] -->|"activates"| ATG101| Source | Relation | Type | Str |
|---|---|---|---|
| ATG | component_of | gene | 0.80 |
| ATG13 | interacts_with | gene | 0.60 |
| ZDHHC13 | activates | gene | 0.60 |
| FIP200 | interacts_with | gene | 0.60 |
| NBR1 | inhibits | gene | 0.60 |
| PARKINSON'S DISEASE | interacts_with | gene | 0.60 |
| ATG14L | activates | gene | 0.60 |
| ATG | interacts_with | gene | 0.60 |
| AUTOPHAGY | interacts_with | gene | 0.60 |
| LYSOSOME | activates | gene | 0.60 |
| RNA | inhibits | gene | 0.60 |
| AMPK | regulates | gene | 0.60 |
| benchmark_ot_ad_answer_key:ATG101 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||