concept

ATG14L

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG14L: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

99Connections

0Hypotheses

0Analyses

50Outgoing

25Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ATG14L
Key Genes/Proteins	ATG, AUTOPHAGY
Related Diseases	Als, ALS, Aging, Tumor, Glioblastoma
Related Pathways	PI3K Signaling, Autophagy, autophagy pathway

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ATG14L["ATG14L"]
    ATG14L -->|"activates"| Als["Als"]
    ATG14L -->|"interacts"| Autophagy["Autophagy"]
    ATG14L -->|"activates"| AUTOPHAGY["AUTOPHAGY"]
    ATG14L -.biomarker for.-> ALS["ALS"]
    ATG14L -.biomarker for.-> Aging["Aging"]
    ATG14L -->|"activates"| Tumor["Tumor"]
    ATG14L -->|"activates"| Glioblastoma["Glioblastoma"]
    ATG14L -->|"inhibits"| Renal_Cell_Carcinoma["Renal Cell Carcinoma"]
    ATG["ATG"] -->|"component_of"| ATG14L
    STX17["STX17"] -->|"interacts"| ATG14L
    MITOCHONDRIA["MITOCHONDRIA"] -.biomarker for.-> ATG14L
    ATG14["ATG14"] -.biomarker for.-> ATG14L
    ATG5["ATG5"] -.biomarker for.-> ATG14L
    AUTOPHAGY -->|"interacts"| ATG14L
    PI3K["PI3K"] -->|"interacts"| ATG14L
    AND["AND"] -->|"interacts"| ATG14L
    ATG8["ATG8"] -->|"interacts"| ATG14L

Outgoing (74)

Target	Relation	Type	Str
PI3K Signaling	involved_in	pathway	0.82
Als	activates	disease	0.75
Autophagy	interacts_with	pathway	0.70
AUTOPHAGY	activates	gene	0.70
Autophagy	activates	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
ALS	biomarker_for	disease	0.65
Aging	biomarker_for	disease	0.65
Tumor	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Tumor	inhibits	disease	0.65
Renal Cell Carcinoma	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Infection	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Als	biomarker_for	disease	0.65
Alzheimer	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
MITOCHONDRIA	biomarker_for	gene	0.60
PGK1	activates	gene	0.60
BECLIN1	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
MTOR	activates	gene	0.60
Mtor	activates	pathway	0.60
BECLIN1	inhibits	gene	0.60
VHL	inhibits	gene	0.60
HIF	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
Oxidative Stress	inhibits	pathway	0.60
Autophagy	inhibits	pathway	0.60
AUTOPHAGY	interacts_with	gene	0.60
UVRAG	interacts_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
BCL-2	interacts_with	gene	0.60
AKT	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
ATG13	activates	gene	0.60
ATG	activates	gene	0.60
ZDHHC13	activates	gene	0.60
LYSOSOME	activates	gene	0.60
FIP200	activates	gene	0.60
ATG101	activates	gene	0.60
ULK1	activates	gene	0.60
SNAP29	interacts_with	gene	0.60
VAMP8	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60

Incoming (25)

Source	Relation	Type	Str
ATG	component_of	gene	0.80
STX17	interacts_with	gene	0.60
MITOCHONDRIA	biomarker_for	gene	0.60
ATG14	biomarker_for	gene	0.60
ATG5	biomarker_for	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
ATG8	interacts_with	gene	0.60
AND	activates	gene	0.60
ULK1	activates	gene	0.60
SNAP29	interacts_with	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AUTOPHAGY	activates	gene	0.60
AGING	inhibits	gene	0.60
LYSOSOME	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
DHHC5	activates	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
BECN1	interacts_with	gene	0.50
ATG14	associated_with	gene	0.50
MITOCHONDRIA	associated_with	cell_type	0.50
ATG5	associated_with	gene	0.50
Pi3K	interacts_with	pathway	0.50
Autophagy	activates	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ATG14L

Understanding Entity Pages

Wiki Pages (20)

Autophagy Mechanisms

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

ZFYVE26 Gene

Autophagy Failure Comparison -- AD/PD/ALS/FTD/HD

autophagy-lysosome-dysfunction

Beclin-1 Protein

RETREG3 (Reticulophagy Regulator 3)

Autophagy-Lysosomal Pathway

PDPK1 Gene

Autophagy Types in Neurodegeneration

Autophagy Enhancement for Tauopathy

autophagy

mTOR Signaling in Autophagy and Lysosomal Function

SEPT2 — Septin 2

ATG7 Protein — Autophagy-Related Protein 7

Autophagy-Lysosome Pathway in Neurodegeneration

fip200

CBS Autophagy-Lysosomal Pathway Dysfunction