concept

AUTOPHAGY-LYSOSOME PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AUTOPHAGY-LYSOSOME PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

1Analyses

17Outgoing

1Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	AUTOPHAGY-LYSOSOME PATHWAY
Key Genes/Proteins	NLRP3, UBIQUITIN, C9orf72, TDP-43, SQSTM1, TARDBP
Related Diseases	AUTOPHAGY, MITOPHAGY, FRONTOTEMPORAL DEMENTIA, DEMENTIA

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

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AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

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Pathway Diagram

graph TD
    AUTOPHAGY_LYSOSOME_PATHWAY["AUTOPHAGY-LYSOSOME PATHWAY"]
    AUTOPHAGY_LYSOSOME_PATHWAY -->|"degrades"| NLRP3["NLRP3"]
    AUTOPHAGY_LYSOSOME_PATHWAY -->|"degrades"| SCIN["SCIN"]
    AUTOPHAGY_LYSOSOME_PATHWAY -->|"involved_in"| Glucocorticoid_Induced_Muscle_["Glucocorticoid-Induced Muscle Atrophy"]
    AUTOPHAGY_LYSOSOME_PATHWAY -->|"regulates"| alpha_synuclein["alpha-synuclein"]
    Schaftoside["Schaftoside"] -->|"activates"| AUTOPHAGY_LYSOSOME_PATHWAY
    extracellular_matrix_remodelin["extracellular matrix remodeling"] -->|"enhances"| AUTOPHAGY_LYSOSOME_PATHWAY
    CAMK2D["CAMK2D"] -->|"regulates"| AUTOPHAGY_LYSOSOME_PATHWAY
    ASTROCYTE["ASTROCYTE"] -->|"regulates"| AUTOPHAGY_LYSOSOME_PATHWAY
    Obestatin["Obestatin"] -->|"regulates"| AUTOPHAGY_LYSOSOME_PATHWAY
    MTOR["MTOR"] -->|"regulates"| AUTOPHAGY_LYSOSOME_PATHWAY
    mTOR["mTOR"] -->|"regulates"| AUTOPHAGY_LYSOSOME_PATHWAY
    alpha_synuclein -->|"inhibits"| AUTOPHAGY_LYSOSOME_PATHWAY

Outgoing (24)

Target	Relation	Type	Str
AUTOPHAGY	associated_with	phenotype	0.45
MICROGLIA	associated_with	cell_type	0.45
NLRP3	associated_with	gene	0.45
UBIQUITIN	associated_with	protein	0.45
C9orf72	associated_with	gene	0.45
MITOPHAGY	associated_with	phenotype	0.45
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.45
RAPAMYCIN	associated_with	drug	0.45
DEMENTIA	associated_with	disease	0.45
TDP-43	associated_with	protein	0.45
SQSTM1	associated_with	gene	0.45
TARDBP	associated_with	gene	0.45
NEURON	associated_with	cell_type	0.45
AMPK	associated_with	gene	0.45
TFEB	associated_with	gene	0.45
ULK1	associated_with	gene	0.45
TBK1	associated_with	gene	0.45

Incoming (17)

Source	Relation	Type	Str
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity