concept

SCIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

125Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

SCIN is a concept in neurodegeneration research. Key relationships include: associated with, regulates, causes. Connected to 53 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	SCIN
Key Genes/Proteins	PIK3C3, MAP3K5, UVRAG, RAC1, BECN1
Related Diseases	Sertoli Cell Polarity, Sertoli Cell Structure, Sertoli cell polarity
Related Pathways	F-Actin Cytoskeleton, Autophagy-Lysosome Pathway

Wiki Pages (2)

Knowledge base pages for this entity

PIK3C3 — Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 (VPS34)

gene · 1529 words

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VPS34 Protein

protein · 528 words

→

Pathway Diagram

graph TD
    SCIN["<b>SCIN</b>"]
    SCIN -->|"involved_in"| F_Actin_Cytoskeleton["F-Actin Cytoskeleton"]
    SCIN -->|"regulates"| BECN1["BECN1"]
    SCIN -->|"regulates"| ACTB["ACTB"]
    SCIN -->|"regulates"| ATG14["ATG14"]
    SCIN -->|"regulates"| GAPDH["GAPDH"]
    SCIN -->|"regulates"| H2AX["H2AX"]
    SCIN -->|"regulates"| Proteasome["Proteasome"]
    SCIN -->|"regulates"| Autophagy["Autophagy"]
    SCIN -->|"regulates"| Ubiquitin_Proteasome["Ubiquitin-Proteasome"]
    SCIN -->|"regulates"| CDC42["CDC42"]
    SCIN -->|"regulates"| HDAC6["HDAC6"]
    SCIN -->|"regulates"| PIK3C3["PIK3C3"]
    PIK3C3 -->|"inhibits"| SCIN
    GJA1["GJA1"] -->|"regulates"| SCIN
    HDAC6 -->|"regulates"| SCIN
    CDC42 -->|"regulates"| SCIN
    CASP3["CASP3"] -->|"regulates"| SCIN
    ACTB -->|"regulates"| SCIN
    TUBULIN["TUBULIN"] -->|"regulates"| SCIN
    LYSOSOME["LYSOSOME"] -->|"causes"| SCIN
    GAPDH -->|"regulates"| SCIN

Outgoing (58)

Target	Relation	Type	Str
F-Actin Cytoskeleton	inhibits	pathway	0.90
Sertoli Cell Polarity	regulates	phenotype	0.88
F-Actin Cytoskeleton	involved_in	pathway	0.85
Sertoli Cell Polarity	modulates	phenotype	0.85
Sertoli Cell Structure	associated_with	phenotype	0.85
Sertoli cell polarity	inhibits	phenotype	0.85
MAP3K5	associated_with	gene	0.60
UVRAG	associated_with	gene	0.60
RAC1	associated_with	gene	0.60
BECN1	regulates	gene	0.60
ACTB	regulates	gene	0.60
ATG14	regulates	gene	0.60
GAPDH	regulates	gene	0.60
TUBB3	associated_with	gene	0.60
H2AX	regulates	gene	0.60
Proteasome	regulates	pathway	0.60
Autophagy	regulates	pathway	0.60
Ubiquitin-Proteasome	regulates	pathway	0.60
STK11	associated_with	gene	0.60
VIM	associated_with	gene	0.60
CDC42	regulates	gene	0.60
HDAC6	regulates	gene	0.60
LAMP1	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
PIK3C3	regulates	gene	0.60
VIMENTIN	associated_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
TJP1	associated_with	gene	0.60
OCLN	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
GJA1	regulates	gene	0.60
LYSOSOME	causes	gene	0.60
TUBULIN	regulates	gene	0.60
CASP3	regulates	gene	0.60
UBIQUITIN	associated_with	gene	0.60
WT1	associated_with	gene	0.60
AND	regulates	gene	0.60
P62	associated_with	gene	0.60
Stem Cell	associated_with	cell_type	0.60
Caspase	regulates	protein	0.60
Actin	activates	protein	0.60
autophagy pathway	participates_in	pathway	0.60
SQSTM1	activates	gene	0.60
STK11	activates	gene	0.60
TJP1	activates	gene	0.60
TUBB3	activates	gene	0.60
UVRAG	activates	gene	0.60
VIM	activates	gene	0.60
WT1	activates	gene	0.60
epigenetic regulation	participates_in	pathway	0.60

Incoming (67)

Source	Relation	Type	Str
PIK3C3	downregulates	gene	0.90
Autophagy-Lysosome Pathway	degrades	pathway	0.85
PIK3C3	associated_with	gene	0.80
PIK3C3	negatively_regulates	gene	0.80
PIK3C3	inhibits	gene	0.64
STK11	associated_with	gene	0.60
PIK3C3	regulates	gene	0.60
MAP1LC3B	associated_with	gene	0.60
OCLN	associated_with	gene	0.60
GJA1	regulates	gene	0.60
VIM	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
HDAC6	regulates	gene	0.60
CDC42	regulates	gene	0.60
SQSTM1	associated_with	gene	0.60
CASP3	regulates	gene	0.60
P62	associated_with	gene	0.60
ACTB	regulates	gene	0.60
TJP1	associated_with	gene	0.60
TUBULIN	regulates	gene	0.60
MAP3K5	associated_with	gene	0.60
LYSOSOME	causes	gene	0.60
UBIQUITIN	associated_with	gene	0.60
GAPDH	regulates	gene	0.60
TUBB3	associated_with	gene	0.60
UVRAG	associated_with	gene	0.60
VIMENTIN	associated_with	gene	0.60
ATG14	regulates	gene	0.60
RAC1	associated_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
BECN1	regulates	gene	0.60
WT1	associated_with	gene	0.60
H2AX	regulates	gene	0.60
CYP11A1	regulates	gene	0.60
AR	activates	gene	0.60
CADM1	biomarker_for	gene	0.60
LIPA	biomarker_for	gene	0.60
Autophagy	regulates	process	0.50
HDAC6	activates	gene	0.50
TUBULIN	activates	protein	0.50
Autophagy	causes	process	0.50
HDAC6	associated_with	gene	0.50
ACTB	activates	gene	0.50
ATG14	activates	gene	0.50
Autophagy	activates	process	0.50
OCLN	activates	gene	0.50
H2AX	activates	gene	0.50
UVRAG	activates	gene	0.50
BECN1	activates	gene	0.50
SQSTM1	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What is the therapeutic window between tau propagation inhibition and essential

neurodegeneration | 2026-04-06 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found