Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CD86: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| M1 pro-inflammatory phenotype | biomarker_for | cell_type | 0.70 |
| microglia | expressed_in | cell_type | 0.70 |
| NEURON | stabilizes | cell_type | 0.70 |
| neuroinflammation | biomarker_for | disease | 0.60 |
| TLR4 | activates | gene | 0.60 |
| CSF1R | associated_with | gene | 0.60 |
| CYBB | associated_with | gene | 0.60 |
| complement cascade | participates_in | pathway | 0.60 |
| CR1 | regulates | gene | 0.60 |
| TNF | inhibits | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| PKC | activates | gene | 0.60 |
| NLRP3 | expressed_in | gene | 0.60 |
| neuroinflammation | activates | disease | 0.60 |
| macrophages | expressed_in | cell_type | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| stem cells | expressed_in | cell_type | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| METTL3 | activates | gene | 0.60 |
| YTHDF1 | activates | gene | 0.60 |
| mitochondrial function | participates_in | pathway | 0.60 |
| ROS | activates | gene | 0.60 |
| NEUROINFLAMMATION | expressed_in | phenotype | 0.55 |
| neurons | expressed_in | cell_type | 0.55 |
| IL-10 | expressed_in | gene | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TRETINOIN (ATRA) | targets | drug | 0.80 |
| CD38 | activates | gene | 0.60 |
| AIF1 | associated_with | gene | 0.60 |
| C1QA | associated_with | gene | 0.60 |
| C1QB | associated_with | gene | 0.60 |
| C3AR1 | associated_with | gene | 0.60 |
| CCR1 | associated_with | gene | 0.60 |
| CD163 | associated_with | gene | 0.60 |
| CD4 | associated_with | gene | 0.60 |
| CD206 | activates | gene | 0.60 |
| CD163 | activates | gene | 0.60 |
| CD80 | activates | gene | 0.60 |
| APP | biomarker_for | gene | 0.60 |
| APP | protects_against | gene | 0.60 |
| CD206 | expressed_in | gene | 0.60 |
| SPINAL CORD | associated_with | brain_region | 0.50 |
| HIPPOCAMPUS | associated_with | brain_region | 0.45 |
| CORTEX | associated_with | brain_region | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||